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Source: The Conversation – Global Perspectives – By Renaud Joannes-Boyau, Professor in Geochronology and Geochemistry, Southern Cross University

When we think of lead poisoning, most of us imagine modern human-made pollution, paint, old pipes, or exhaust fumes.

But our new study, published today in Science Advances, reveals something far more surprising: our ancestors were exposed to lead for millions of years, and it may have helped shape the evolution of the human brain.

This discovery reveals the toxic substance we battle today has been intertwined with the human evolution story from its very beginning.

It reshapes our understanding of both past and present, tracing a continuous thread between ancient environments, genetic adaptation, and the unfolding evolution of human intelligence.

A poison older than humanity itself

Lead is a powerful neurotoxin that disrupts the growth and function of both brain and body. There is no safe level of lead exposure, and even the smallest traces can impair memory, learning and behaviour, especially in children. That’s why eliminating lead from petrol, paint and plumbing is one of the most important public health initiatives.

Yet while analysing ancient teeth at Southern Cross University, we uncovered something wholly unexpected: clear traces of lead sealed within the fossils of early humans and other ancestral species.

These specimens, recovered from Africa, Asia and Europe, were up to two million years old.

Using lasers finer than a strand of hair, we scanned each tooth layer by layer – much like reading the growth rings of a tree. Each band recorded a brief chapter of the individual’s life. When lead entered the body, it left a vivid chemical signature.

These signatures revealed that exposure was not rare or accidental; it occurred repeatedly over time.

Where did this lead come from?

Our findings show that early humans were never shielded from lead by the natural world. On the contrary, it was part of their world too.

The lead we found wasn’t from mining or smelting – those activities are from relatively recent human history.

Instead, it likely came from natural sources such as volcanic dust, mineral-rich soils, and groundwater flowing through lead-bearing rocks in caves. During times of drought or food shortage, early humans might have dug for water or eaten plants and roots that absorbed lead from the soil.

Every fossil tooth we study is a record of survival. A small diary of the early life of the individual, written in minerals instead of words. These ancient traces tell us that even as our ancestors struggled to find food, shelter and community, they were also navigating a world filled with unseen dangers.

From fossil teeth to living brain cells

To understand how this ancient exposure might have affected brain development, we teamed up with geneticists and neuroscientists, and used stem cells to grow tiny versions of human brain tissue, called brain organoids. These small collections of cells have many of the features of developing human brain tissue.

We gave some of these organoids a modern human version of a gene called NOVA1, and others an archaic, extinct version of the gene similar to what Neanderthals and Denisovans carried. NOVA1 is a gene that orchestrates early neurodevelopment. It also initiates the response of brain cells to lead contaminants.

Then, we exposed both sets of organoids to very small, realistic amounts of lead – what ancient humans might have encountered naturally.

The difference was striking. The organoids with the ancient gene showed clear signs of stress. Neural connections didn’t form as efficiently, and key pathways linked to communication and social behaviour were disrupted. The modern-gene organoids, however, were far more resilient.

It seems that somewhere along the evolutionary path, our species may have developed a better built-in protection against the damaging effects of lead.

A story of struggle

The environment – complete with lead exposure – pushed modern human populations to adapt. Individuals with genetic variations that help them resist a threat are more likely to survive and pass those traits to future generations.

In this way, lead exposure may have been one of the many unseen forces that sculpted the human story. By favouring genes that strengthened our brains against environmental stress, it could have subtly shaped the way our neural networks developed, influencing everything from cognition to the early roots of speech and social connection.

This didn’t change the fact lead continues to be a toxic chemical. It remains one of the most damaging substances to our brains.

But evolution often works through struggle – even negative experiences can leave lasting, sometimes beneficial marks on our species.

New context for a modern problem

Understanding our long relationship with lead gives new context to a very modern problem. Despite decades of bans and regulations, lead poisoning remains a global health issue. Most recent estimates from UNICEF show one in three children worldwide still have blood lead levels high enough to cause harm.

Our discovery shows human biology evolved in a world full of chemical challenges. What changed is not the presence of toxic substances, but the intensity of our exposure.

When we look at the past through the lens of science, we don’t just uncover old bones, we uncover ourselves.

In the industrial age, we’ve massively amplified what used to be short and infrequent natural exposure. By studying how our ancestors’ bodies and genes responded to environmental stress, we can learn how to build a healthier, more resilient future.

Renaud Joannes-Boyau receives funding from the Australian Research Council.

Manish Arora receives funding from US National Institutes of Health. He is the founder of Linus Biotechnology, a start-up company that develops biomarkers for various health disorders.

Alysson R. Muotri does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Human ancestors were exposed to lead millions of years ago, and it shaped our evolution – https://theconversation.com/human-ancestors-were-exposed-to-lead-millions-of-years-ago-and-it-shaped-our-evolution-267318

Source: The Conversation – Global Perspectives – By Luke Hartigan, Lecturer in Economics, University of Sydney

The price of gold surged above US$4,100 (A$6,300) an ounce on Wednesday for the first time, taking this year’s extraordinary rally to more than 50%.

The speed of the upswing has been much faster than analysts had predicted and brings the total gains to nearly 100% since the current run started in early 2024.

The soaring price of gold has captured investors’ hearts and wallets and resulted in long lines of people forming outside gold dealers in Sydney to get their hands on the precious metal.

What explains the soaring price of gold?

A number of reasons have been suggested to explain the current record run for gold. These include greater economic uncertainties from ballooning government debt levels and the current US government shutdown.

There are also growing worries about the independence of the US Federal Reserve. If political interference pushes down US interest rates, that could see a resurgence in inflation. Gold is traditionally seen as a hedge against inflation.

But these factors are unlikely to be the main reasons behind the meteoric rise in gold prices.

For starters, the price of gold has been on a sustained upward trajectory for the past few years. That’s well before any of those factors emerged as an issue.

The more likely explanation for the current gold price rally is growing demand from gold exchange-traded funds (ETFs).

These funds track the movements of gold, or other assets such as stocks or bonds, and are traded on the stock exchange. This makes assets such as commodities much more accessible to investors.

Before the first gold ETF was launched in 2003, it was considered too difficult for regular investors to get gold exposure.

Now gold ETFs are widely available, gold can be traded like any other financial asset. This appears to be changing investors’ view of gold’s traditional role as a safe-haven asset in times of political or financial turmoil, when other assets such as stocks are more risky.

In addition to retail investor demand, some emerging market economies – notably China and Russia – are switching their official reserve assets out of currencies such as the US dollar and into gold.

According to the International Monetary Fund, central bank holdings of physical gold in emerging markets have risen 161% since 2006 to be around 10,300 tonnes.

To put this into perspective, emerging market gold holdings grew by only 50% over the 50 years to 2005.

Research suggests the reason for the switch into gold by emerging market economies is the increasing use of financial sanctions by the US and other governments that represent the major reserve currencies (the US dollar, euro, Japanese yen, and British pound).

Indeed, Russia became a net buyer of gold in 2006 and accelerated its gold purchases following its annexation of Crimea in 2014. It now has one of the largest stockpiles in the world.

Meanwhile, China has been selling down its holdings of US government bonds and switching to buying gold in a process referred to as “de-dollarisation”. It wants to reduce its dependency on the US currency.

Emerging market central banks also lifted their gold holdings after Russia’s exclusion from the international payments system known as SWIFT and a proposal by US and European governments to seize Russian central bank reserves to help fund support for Ukraine.

Further de-dollarisation efforts by emerging market economies are expected to continue. Many of these economies now view the major Western currencies as carrying unwanted risk of financial sanctions. This is not the case with gold. This could mean financial sanctions become a less effective policy tool in the future.

Could gold have further to run?

Ongoing demand from Russia and China, and investor demand for gold ETFs, means the gold price could rally further. Both factors represent sustained increases in demand, in addition to existing demand for jewellery and electronics.

Further price rises will likely fuel increased ETF inflows via the “fear of missing out” effect.

The World Gold Council last week reported record monthly inflows in September. For the September quarter as a whole, ETF inflows topped US$26 billion and for the nine months to September, fund inflows totalled US$64 billion.

In contrast, emerging market central bank demand for gold is less affected by price and more driven by geopolitical factors, which supports increasing demand for gold.

Based on these two drivers, analysts at Goldman Sachs have already revised up their price target for gold to US$4,900 an ounce by the end of the 2026.

Why gold’s rise is a win for Australia

What does the current gold rally mean for Australia?

As the world’s third-largest producer of gold, with at least 19% of known deposits, Australia will benefit from further increases in gold prices.

In fact, the Department of Industry, Science and Resources now expects the value of gold exports to overtake liquefied natural gas exports next year.

This will see gold become our second-most important export behind that other “precious” metal: iron ore.

Luke Hartigan receives funding from the Australian Research Council (DP230100959).

– ref. The price of gold is skyrocketing. Why is this, and will it continue? – https://theconversation.com/the-price-of-gold-is-skyrocketing-why-is-this-and-will-it-continue-267004

Source: The Conversation – Global Perspectives – By Martin Kear, Sessional Lecturer, Department of Government and International Relations, University of Sydney

Despite the euphoria surrounding the ceasefire between Hamas and Israel, Gaza is still wracked with violence.

More than two dozen Palestinians have been killed in recent days in clashes between Hamas and members of various clans. Hamas has also reportedly executed blindfolded men in a public square.

With the Israeli military withdrawing to pre-determined ceasefire lines, Hamas members are beginning to re-assert their control. However, powerful clans are also jockeying for position – some allied to Hamas’ ideological rival, the West Bank-based Fatah movement, and some backed by Israel.

So, who are these clans? What role do they play in Gaza? And how much of a threat are they to Hamas?

Who are the clans?

Familial clans have existed in Palestinian society for centuries. In recent decades, they have come to play a key role in Palestinian politics.

The clans are primarily collections of family groups in various parts of Gaza. One of the largest and most well-armed is the Dughmush clan in Gaza City, headed by Mumtaz Dughmush. This clan was immediately targeted by Hamas after the ceasefire.

The al-Majayda clan also holds sway in part of Khan Younis. Hamas forces raided their neighbourhood earlier this month, killing several family members. This week, however, the clan publicly supported Hamas’ effort to regain control over Gaza.

Importantly, these clans and their relationships with Hamas and Fatah are dynamic and constantly evolving. Members of both Hamas and Fatah also belong to clans. This often leads to clashes over territory and control, with clan loyalties often outweighing movement allegiances.

As Israeli historian Dror Ze’evi notes, any attempt by Hamas or Fatah to disarm the clans would be seen as an affront and met with serious opposition.

A long history of entrenched power

After the 1948 war that saw the creation of Israel and the Palestinian al-naqbah (or Nakba), around 750,000 Palestinians fled Israel to the Gaza Strip, West Bank and neighbouring Arab states.

This was when clans began to assume traditional roles of mediators and patrons. Their organised structures made them best-placed to provide welfare and assistance to a shattered Palestinian society.

As law and order, security and financial independence improved in the territories in the subsequent decades, Palestinians came to rely less on their support. This brought a decline in their power and influence.

This changed, though, during the First Intifada (1987–93) and Second Intifada (2000–05) when Palestinian society was again plunged into crisis. This was especially true in the Gaza Strip, which was known as the engine room of organised Palestinian resistance.

The Second Intifada, in particular, changed the role of the clans significantly, after Israel destroyed much of the organised Palestinian security forces and infrastructure in the territories.

With neither Hamas nor Fatah able to ensure the safety of Palestinians, this created a security vacuum. And some of the clans exploited this by transforming into paramilitary organisations. Again, this was especially true in the Gaza Strip, where Israel’s efforts to crush Palestinian resistance were felt most intensely.

When the Second Intifada ended, the Gazan clans retained a significant amount of political influence and military power. After Hamas won the 2006 elections, some Fatah-aligned clans tried to prevent it from taking power.

So entrenched were these clans that when Hamas finally assumed control of Gaza in 2007, it took the movement a year to effectively bring the more powerful clans under its authority. Even then, it was more of a truce than a victory for Hamas.

Israel backing Hamas rivals

This status quo remained until Hamas’ October 7 2023 terrorist attacks on Israel. Israel’s revenge for these attacks devastated the Gaza Strip, once again robbing Gazans of any semblance of safety and security.

Now, with Israel’s partial troop withdrawal, another security vacuum has been created. And many clans appear keen to fill it, some with the help of Israel.

In June, Israeli Prime Minister Benjamin Netanyahu admitted his government was arming some Gazan clans, gangs and militias, such as the Popular Forces, led by Yasser Abu Shabab.

Netanyahu’s rationale was that any opposition to Hamas helped Israel and saved soldiers’ lives. It also pitted Palestinian against Palestinian, placing additional pressure on Hamas.

After the ceasefire came into effect, Hamas began targeting what it called
“collaborators and traitors” – an apparent reference to those clans and gangs cooperating with Israel.

The Popular Forces, meanwhile, have refused to lay down their arms. A dozen other new militias have also reportedly emerged across the strip in recent days, including one led by Hossam al-Astal, who said:

Hamas was always betting that there won’t be any alternative to replace them in Gaza, but now I’m telling you, today, there is an alternative force to Hamas. It could be me or Abu Shabab or anyone else, but alternatives today exist.

While this violence between Hamas and rival groups does not directly affect the ceasefire that ended the war, it is evidence that Israel is still attempting to meddle in Gaza’s security and exert its control.

But the peace plan negotiated by US President Donald Trump looks shakier by the day, given its call for Hamas to disarm. Trump said this week if Hamas refused to disarm themselves, “we will disarm them […] perhaps violently”.

The peace plan also calls for Hamas to withdraw from Palestinian politics, to be replaced eventually by the Palestinian Authority, which currently administers parts of the West Bank. However, Netanyahu has repeatedly rejected the Palestinian Authority assuming control of Gaza.

This ambiguity over the future governance of Gaza opens the possibility that the more powerful clans could become alternate centres of political power, as they had during the Second Intifada. This time they may do so under the auspices of Israel’s military occupation.

This would further fracture Gaza and weaken any effort by the Palestinian Authority to reunite the territories under a single governance structure. It would also make a future Palestinian state tenuous.

Also, Hamas will not go quietly. And this is a very real danger to peace and security in Gaza, especially if Hamas sees any resistance to its authority from the clans as little more than a proxy war with Israel.

Martin Kear does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Hamas is battling powerful clans for control in Gaza – who are these groups and what threat do they pose? – https://theconversation.com/hamas-is-battling-powerful-clans-for-control-in-gaza-who-are-these-groups-and-what-threat-do-they-pose-267446