How sailing voyages can inspire the next generation of ocean scientists and advocates

Source: The Conversation – UK – By Pamela Buchan, Research Fellow, Geography, University of Exeter

Setting sail from the busy port of Plymouth in Devon, the tall ship Pelican of London takes young people to sea, often for the first time.

During each nine-day voyage, the UK-based sailing trainees, who often come from socio-economically challenging backgrounds, become crew members. They not only learn the ropes (literally) but also engage in ocean science and stewardship activities.

As marine and outdoor education researchers, we wanted to find out whether mixing sail training and Steams (science, technology, engineering, art, mathematics and sustainability) activities can inspire young people to pursue a more ocean-focused career, and a long-term commitment to ocean care.

Research shows that a strong connection with the ocean can drive people to be active marine citizens. This means they take responsibility for ocean health not only in their own lives but as advocates for more sustainable interactions with the ocean.

Over the past year, we have worked with Charly Braungardt, head scientist with the charity Pelican of London, to create a new theory of how sail training with Steams activities can change the paths that trainees pursue.

Based on scientific evidence, our theory of change models how Steams activities can cause positive changes in personal development and knowledge and understanding of the ocean (known as ocean literacy). It shows how the voyages can develop trainees’ strong connections with the ocean and encourage them to act responsibly towards it.

Tracking change

Surveys with the participants before and after the voyage, and six months later, measure any changes that occur – and how these persist. Through our evaluation, we’re exploring how combining voyages with Steams activities can go beyond personal development to produce deep, long-lasting effects.

Our pilot study has already shown how the sail training and Steams combination helps to develop confidence, ocean literacy and ocean connections.

For example, the boost to self-esteem and feelings of capability that occur on board help young people develop their marine identity – the ocean becomes an important part of a person’s sense of who they are. As one trainee put it: “I think the ocean is me and the ocean will and forever be part of me.”


Swimming, sailing, even just building a sandcastle – the ocean benefits our physical and mental wellbeing. Curious about how a strong coastal connection helps drive marine conservation, scientists are diving in to investigate the power of blue health.

This article is part of a series, Vitamin Sea, exploring how the ocean can be enhanced by our interaction with it.


As crew members, trainees access a world and traditional culture largely unknown to them before the voyage. They learn to live with others in a confined space, working together in small teams to keep watch on 24-hour rotas.

Trainees are encouraged to step out of their comfort zone through activities such as climbing the rigging and swimming off the vessel. Our pilot evaluation found the voyages built the trainees’ confidence and social skills, boosting self-esteem and feelings of capability.

One trainee said: “I’ve felt pretty disappointed in myself not committing to my education or only doing something with minimal effort. But after this voyage, I want to give it my all.”




Read more:
Five ways to inspire ocean connection: reflections from my 40-year marine ecology career


The Steams voyages encourage the development of scientific skills and ocean literacy through the lens of creative tasks at sea. These activities are led by a scientist-in-residence who provides mentoring and introduces research techniques.

The voyage gives trainees the opportunity to use scientific equipment, ranging from plankton nets and microscopes to cutting-edge technology such as remotely operated vehicles. The Steams activities introduce marine research as a potential career to these young people. One said they wanted to train as a marine engineer at nautical college following the voyage.

Ocean experiences provide a foundation for ocean connection. Trainees experience the ocean in sunshine and in gales, day and night, rolling with the waves and observing marine life in its natural environment.

Citizen science projects such as wildlife surveys and recorded beach cleans also develop their ocean stewardship knowledge and skills. One trainee explained how they have “become more interested [in] our marine life and creative ways to help protect it”.

Over the next 12 months, the information we collect from the voyages will help us to better understand the benefits and contribute to an important marine social science data gap in young people. It is important to understand how to develop young people’s relationships with the ocean, and the knowledge and skills that will empower the next generation of marine citizens.

As one trainee put it: “Being out on the Pelican showed me how vast and powerful the sea is – and how important it is to respect and care for it.”


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The Conversation

Pamela Buchan received funding from Economic and Social Research Council for the research cited in this article. The sail training evaluation project received funding from Sail Training International. We would like to thank Charlotte Braungardt for her contribution to this project.

Alun Morgan is affiliated with the Pelican of London as an Ambassador for the organisation

ref. How sailing voyages can inspire the next generation of ocean scientists and advocates – https://theconversation.com/how-sailing-voyages-can-inspire-the-next-generation-of-ocean-scientists-and-advocates-273715

What Kate Nash’s grassroots music protest reveals about touring and streaming

Source: The Conversation – UK – By Paul G. Oliver, Lecturer in Digital Innovation and Entrepreneurship, Edinburgh Napier University

Kate Nash performing in Amsterdam in 2012. Wiki Commons, CC BY-SA

In November 2025, singer Kate Nash stood outside the London offices of Spotify and Live Nation with placards, arguing that the music economy no longer works for many working musicians.

The protest drew attention to the financial strain of touring at scale. In February 2026, she elaborated on these concerns in testimony before a UK parliamentary select committee, stating that she lost £26,000 on the European leg of her tour and covered those losses only by selling content on OnlyFans.

In her testimony, Nash criticised major industry players for what she called a “destructive influence” on artists’ finances. She warned that rising costs, including the complexities of post-Brexit touring, could limit both cultural reach and economic viability for UK performers.
Nash has been a well-known figure in British music for years, but her public frustration highlights a disconnect between visibility and a sense of security that many mid-career artists understand.

Streaming sits at the centre of this tension, as digital platforms pool subscription revenue and redistribute it based on a share of total listening. Critics argue that this structure concentrates income on global hits while leaving most artists with fractions of a penny per play. Artists increasingly describe having to juggle budgets that resemble household accounts, such as vans against fuel, hotels against sofa-surfing and merchandise against storage fees. One cancelled show can tip a tour from workable to loss-making.




Read more:
Why musicians are leaving Spotify – and what it means for the music you love


At the same time, data shows that grassroots music venues in the UK are struggling. Music Venue Trust’s 2025 report found that over the preceding year, more than half of these venues made no profit and dozens closed.

These small venues, often holding just a few hundred people, help sustain touring circuits and renew local music scenes. When they close, much of the cultural support for new talent disappears.

Who pays for live music?

Supporters of the live sector have proposed measures such as ticket levies on large shows to support smaller venues and planning protections for long-running clubs facing redevelopment. These ideas have been debated in Parliament and city-level cultural forums, including a UK government call for a voluntary arena and stadium ticket levy to protect grassroots venues.

Platforms and promoters resist the bleakest readings. Streaming services emphasise the sums they distribute and the global audiences they reach, while large promoters point to rising touring costs and the risks of softer ticket sales. At the same time, analyses of how streaming revenues are shared suggest that most artists receive only small fractions of subscription income. This is not a simple story of villains and victims, yet the distribution of rewards continues to trouble many performers.

Politicians have taken notice, reopening questions about streaming payments and transparency and examining how live music might be supported more broadly. A fan-led review of the live sector launched by MPs has invited evidence from artists, promoters and audiences about the pressures facing touring and small venues.

Similar debates are playing out at city level. The London Assembly has already backed a voluntary ticket levy on arena and stadium shows to help grassroots spaces. Campaign groups and commentators have also pushed for clearer contracts, including initiatives such as the Musicians’ Union’s “Fix Streaming” campaign, which calls on Parliament to support fairer streaming royalty distribution for all creators.

Some critics go further, arguing that the streaming model continues to channel a disproportionate share of revenue to the biggest acts and pressing for reforms to support a broader tier of working musicians, drawing on evidence from the UK Parliament’s inquiry into the economics of music streaming.

These problems have effects beyond money. As touring becomes more difficult and there are fewer venues, fewer acts are willing to take risks with new audiences. Local music scenes are shrinking, and young performers lack opportunities to try out new material, make mistakes, and improve. Audiences feel this too, when there are fewer shows, less variety and favourite bands stop touring.

Nash doesn’t claim to speak for everyone, and one protest can’t represent the whole industry. However, her choice to share frustrations usually kept private says something about today’s situation. Popular music has always mixed glamour with uncertain pay and long hours, but what’s new is how openly artists are now asking if the current system can support lasting careers.

If this middle ground continues to shrink, listeners might notice the change not in statistics but in daily life: fewer tours, closed local venues and bands quietly deciding that touring is no longer worth it.


Looking for something good? Cut through the noise with a carefully curated selection of the latest releases, live events and exhibitions, straight to your inbox every fortnight, on Fridays. Sign up here.


The Conversation

Paul G. Oliver does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. What Kate Nash’s grassroots music protest reveals about touring and streaming – https://theconversation.com/what-kate-nashs-grassroots-music-protest-reveals-about-touring-and-streaming-275717

How can Europe meet the challenge posed by the retreat of the US?

Source: The Conversation – UK – By Niall Oddy, Staff Tutor in History, The Open University

At the Munich security conference, US secretary of state Marco Rubio spoke more warmly about the transatlantic relationship than US vice-president J.D. Vance at the same venue last year. However, faced with the presidency of the erratic Donald Trump, the need for Europe to do more to protect its security remains urgent.

In a later speech in Munich Kaja Kallas, vice-president of the European Commission and the EU’s high representative for foreign affairs and security policy, spoke of the “need to reclaim European agency”.

Meanwhile, UK prime minister Keir Starmer announced he wants closer relations with Europe, a decade after Brexit, stating: “there is no British security without Europe, and no European security without Britain. That is the lesson of history, and is today’s reality as well.”

People often use the word “Europe” when they are referring to the European Union. Doing so overlooks non-EU countries, like the UK, that are also part of Europe and share an equal stake in the continent’s security.

Whereas the EU is a political body, Europe is an idea. It might be the name of a continent, but the word Europe rarely refers only to geography. When Giorgia Meloni, the Italian prime minister, stated that Europe has “lost itself”, and when Ursula von der Leyen, the president of the European Commission, spoke of the “European way of life”, they were referring to the people of Europe and the sense that they have customs and values in common that distinguish them from the rest of the world. French president Emmanuel Macron was doing the same when he used the phrase “European civilisation”.

What are these values that supposedly unite Europeans? In some quarters, the emphasis is on secularism. The 2007 Lisbon Treaty declared that the EU “is founded on the values of respect for human dignity, freedom, democracy, equality, the rule of law and respect for human rights”. However, the lack of mention of the continent’s Christian heritage was contested. Viktor Orbán, the prime minister of Hungary, is one of the most vocal advocates of the idea that European culture is Christian.

These different ideas about what Europe is and what constitutes European culture have long histories. When the Reformation of the 16th century divided Catholics and Protestants, shared hostility towards the Muslim Ottoman Empire, which controlled much of the Balkans and was continuing to expand, provided a sense of overarching unity.

The more secular understanding of Europe developed in the 17th and 18th centuries. The thirty years’ war (1618-48) ended with peace negotiations that did not involve the Pope, as had previously been the norm. Increasingly, Europe’s political culture, not just its religion, was regarded as its most distinctive feature. In the words of French philosopher Voltaire, Europe was “a kind of great republic” sharing “the same principle of public law and politics, unknown in other parts of the world”.

Even today’s tensions between national identities and Europeanism are nothing new. The 19th century was a period of national awakening, with the formation of a unified Italian state in 1861 and the unification of the state of Germany in 1871. At the same time, philosopher Friedrich Nietzsche argued that “Europeans are becoming more similar to each other” and French author Victor Hugo predicted a “united states of Europe”.

With the swift Nazi advances in western and eastern Europe in the early years of the second world war, the German press claimed in November 1941 that “the United States of Europe has at last become a reality”. After Nazi Germany’s defeat in 1945, this notion of the continent united under the domination of one nation was superseded by a commitment to cooperation. This led in 1951 to the formation of the European Coal and Steel Community and in 1957 to the European Economic Community, which eventually morphed into the European Union with its motto of “united in diversity”.

National interests and international alliances

Today it is people from non-EU countries who are often the most vigorous defenders of so-called “European values”. Since October 2024 Georgians have been protesting the authoritarianism of their government, carrying the EU flag alongside the national one and placards that read “we are Europe”. And while European leaders discuss how to respond to the threat posed by the Russian Federation, Ukrainians are fighting for their lives and strengthening European security by doing so.

Russia’s first attack on Ukraine – in Crimea in 2014 – came in the aftermath of former president Viktor Yanukovych’s downfall following protests triggered by his rejection of closer ties with the EU.

Through their actions, Ukrainians and Georgians emphasise national autonomy as part of a wider values-oriented European identity, rather than pitting nationhood against Europeanism.

If Europe is to face up to challenges and defend itself without the guarantee of US support, EU and non-EU countries must find ways to work together. For this we need a shared vision about what unites disparate nationalities and underpins European cooperation. Historically, ideas about what Europe is and what Europe stands for have been shaped in western and central Europe. It is time to look to lessons from the eastern borderlands where, as the examples of Ukrainian and Georgian resistance show, values of freedom and democracy are being lived in practice.

The Conversation

Niall Oddy does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. How can Europe meet the challenge posed by the retreat of the US? – https://theconversation.com/how-can-europe-meet-the-challenge-posed-by-the-retreat-of-the-us-274687

Are you a Dink, Alice or Henry? How social mobility is different for today’s young people

Source: The Conversation – UK – By Renaud Foucart, Senior Lecturer in Economics, Lancaster University Management School, Lancaster University

The carefree lifestyle of two Dinks. Opolja/Shutterstock

When your parents were in their 20s and 30s, they probably had a job, a house and financial security. A generation later, you get a variety of food they could not have imagined, low-cost air travel and a smartphone more powerful than the fastest supercomputers of the 1990s.

This new reality is leading to the resurgence of a different kind of class identification for young people. Middle class doesn’t look like it used to. Instead, you may consider yourself a “Dink” or a “Henry”.

Standing for “dual income and no kids”, Dink was coined in the 1980s to reflect the lifestyle of couples who chose the joys of technology, travel and restaurants over raising a family. As fertility rates fall worldwide, the term is making a comeback, with TikTok users showing off a life of boutique workouts, fancy brunches and wanderlust.

A woman born in England or Wales in 2007 is projected to have her first child at age 35 and to have an average of 1.52 children, compared with 2.04 for her mother’s generation.

The Dink lifestyle is attractive to some: more money and time for yourselves. But on the salary of an average UK household, you still won’t be able to buy an average house.

Why does it seem so much harder now? It’s not that this generation is poorer: on average, full-time employees between 18 and 21 years old make £499 a week. It rises fast: for those aged 22-29 the figure is £648, and £805 for 30-39.

For all age groups, salaries have barely increased since 2008, once you control for the fact that prices have risen by a lot. Still, compared with someone who entered the workforce 25 years ago, you will earn, on average, about 15% more even when adjusting for prices.

The key is that, while you earn more than your parents and grandparents, what’s cheap and what’s expensive has completely flipped.


No one’s 20s and 30s look the same. You might be saving for a mortgage or just struggling to pay rent. You could be swiping dating apps, or trying to understand childcare. No matter your current challenges, our Quarter Life series has articles to share in the group chat, or just to remind you that you’re not alone.

Read more from Quarter Life:


There are two kinds of things money can buy. There are things available only in fixed quantities – housing in a desirable location, a person’s time or social status. Then, there are things that technology can now produce in near-infinite quantities – a huge TV set, high-speed internet on a phone, or fresh fruits and vegetables from the other side of the world.

Compared with previous generations, you’re only richer in the latter. Since 2000, UK house prices have increased twice as fast as everything else. The share of young Brits who own their homes is 25% lower than in 1990. This might partly explain Dink logic – if you don’t have hope of affording a home, why not spend more on your lifestyle?

The tax brackets that define you

In this world where buying a house without family help has become the new luxury, the British tax system provides a handy guide of where you belong. Here’s how the figures break down.

You might not be a Dink, but an “Alice” – “asset-limited, income-constrained, employed” – part of the working poor who can’t even dream of saving for a deposit. Nearly 3 million people in the UK are working and receiving Universal Credit.

But once you start earning more than £684 a month, you hit the first trap of the tax system. For every additional £1 you earn from working, you lose 55p from the benefits you receive – so in effect, you only keep 45p up to the point where the amount of benefit you receive is zero.

If you escape this first trap and earn more, you may be able to afford a small house, or one in a cheaper region. Just not the same kind of place someone doing your job could buy 30 years ago.

If you climb up the income ladder, you’ll likely hit the second trap and become a Henry – “high earner, not rich yet”.

The moment you become part of the roughly 2 million taxpayers who earn £100,000 a year, your marginal tax rate becomes 60% – which means for each additional £1 you get, you only keep 40p. If you are young and went to university, you also pay an extra 9% on student loan repayment, meaning you only keep 31p for each additional £1.

And that’s only if you stay a Dink (or the single-equivalent Sink). If you have kids, you may actually lose money when you earn more, because you will lose the right to free childcare (you lost your child benefits back at £60,000). You may prefer to be a Dinkwad – a “Dink with a dog”.

Focus on a small dog, held by a young gay couple
The Dinkwad life.
Andrii Nekrasov/Shutterstock

The traditional middle class was defined by homeownership and financial security, both things you could achieve through professional work. What unites today’s Henrys, Alices and Dinks is they can enjoy consumption levels their parents in the same social class would never have imagined, but can’t buy the same house as them.

The solution to this is simple economics, but complex politics: if you want cheaper houses, you must build more of them. That means building in less desirable locations, turning individual houses into flats, or overcoming opposition from older homeowners who often resist new housing developments in their neighbourhoods.

So, when your judgmental uncle remarks that “if you ate fewer avocados and lattes, you’d be able to buy a house just like I did”, you may want to explain how the relative prices of an avocado and a house have changed over time. If you’re not saving for a deposit, buying avocados may simply be the most rational thing to do.

The Conversation

Renaud Foucart does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Are you a Dink, Alice or Henry? How social mobility is different for today’s young people – https://theconversation.com/are-you-a-dink-alice-or-henry-how-social-mobility-is-different-for-todays-young-people-275129

AlphaGenome, une nouvelle avancée en intelligence artificielle pour explorer les effets des mutations génétiques

Source: The Conversation – France in French (2) – By Élodie Laine, Professeure en biologie computationnelle, Sorbonne Université

Même une mutation génétique très simple – une lettre qui change dans l’immense chaîne composée d’A, T, C et G – peut avoir des conséquences sur la santé. Sangharsh Lohakare/Unsplash, CC BY

Notre ADN est composé d’un enchaînement de quatre petites molécules appelées « acides nucléiques » et dénotées par les lettres A, C, G, et T. Parfois, une mutation génétique a lieu et affecte notre santé. Une simple modification dans la grande séquence de lettres qui constitue notre génome peut suffire à affecter l’expression des gènes ou les versions des protéines produites à partir de ces gènes.

Mais on ne sait pas, à l’heure actuelle, expliquer systématiquement comment telle ou telle mutation génétique peut avoir tel ou tel effet. C’est la question à laquelle AlphaGenome, le nouveau logiciel d’intelligence artificielle présenté dans la revue Nature par Google, tente de répondre.

AlphaGenome analyse un million d’acides nucléiques à la fois, et prédit, pour chacun d’eux, des milliers de quantités, qui sont autant de facettes de la régulation de nos gènes pour façonner nos tissus et nos organes.

Coupler un tel niveau de résolution avec un contexte aussi long (un million de lettres !) et prédire autant d’aspects de la régulation du génome relève du tour de force. Cependant, ce nouvel opus de la série Alpha de DeepMind ne représente pas une avancée aussi spectaculaire qu’AlphaGo ou AlphaFold, par exemple.

AlphaGenome affine une approche existante, déjà implémentée dans Enformer et Borzoi, deux modèles d’apprentissage profond développés chez Google qui ont fait leurs preuves. Il améliore, d’une part, leur efficacité par des optimisations techniques et, d’autre part, leur pertinence, en modélisant plus finement la complexité des processus génétiques.




À lire aussi :
Décrypter notre génome grâce à l’intelligence artificielle


Pourquoi cette avancée est importante

L’enjeu de ce travail est de taille pour la santé humaine. Les bases de données génomiques de populations humaines recensent près de 800 millions de variations ponctuelles – c’est-à-dire des changements portant sur une seule lettre du code génétique – dont l’impact sur notre santé reste largement inexploré. Identifier quelles sont celles qui sont à l’origine de maladies ou de dysfonctionnements, et comprendre leurs mécanismes d’action, est crucial.

Par exemple, dans certaines leucémies, une mutation d’un seul acide nucléique active de manière inappropriée un gène bien spécifique. AlphaGenome confirme le mécanisme déjà connu de cette activation aberrante : la mutation permet à un régulateur génétique de s’accrocher au gène, et modifie les marques épigénétiques alentour.

Ainsi, en unifiant plusieurs dimensions de la régulation génétique, AlphaGenome s’impose comme un modèle de fondation, c’est-à-dire un modèle générique qui peut être transféré ou appliqué facilement à plusieurs problèmes.

Quelles sont les suites de ces travaux ?

Plusieurs limitations tempèrent néanmoins l’enthousiasme.

Par exemple, les prédictions sur différentes facettes d’un même processus biologique ne sont pas toujours cohérentes entre elles, révélant que le modèle traite encore ces modalités de façon relativement cloisonnée.

Le modèle peine aussi à capturer la « spécificité tissulaire », c’est-à-dire le fait qu’un même variant génétique peut être délétère dans un tissu et neutre dans un autre.

De plus, il reste difficile de quantifier l’ampleur de l’effet d’une mutation.

Enfin, AlphaGenome prédit des conséquences moléculaires, pas des symptômes ni des diagnostics – or, entre une variation d’ADN et une maladie, il reste énormément de travail pour comprendre les relations entre ces différents niveaux ; et il n’a pas encore été validé sur des génomes individuels – un passage obligé pour toute application en médecine personnalisée, où l’enjeu serait d’interpréter le profil génétique unique d’un patient pour prédire sa susceptibilité à certaines maladies ou adapter son traitement.

Au-delà de ces enjeux pour la santé humaine, comment transférer cette connaissance à la biodiversité dans son ensemble ? AlphaGenome dépend en effet de mesures expérimentales, accessibles en abondance uniquement pour une poignée d’espèces (l’humain et quelques organismes modèles). Une autre famille de modèles pourrait ici jouer un rôle complémentaire : les « modèles de langage génomique », qui fonctionnent un peu comme ChatGPT mais pour prédire la suite d’une séquence d’ADN plutôt que la suite d’une phrase. Ces modèles, entraînés sur des millions de séquences génomiques, peuvent ainsi capturer les règles et les motifs conservés au cours de l’évolution, ce qui permet de déchiffrer des génomes inconnus.

Rien de tout cela n’existerait sans les grandes bases de données publiques et le travail cumulé de la recherche académique et des consortia ouverts, qui ont produit, standardisé et partagé les données nécessaires à l’entraînement de ces modèles. La suite logique est claire : la science doit rester ouverte, au service de la société. L’équipe d’AlphaGenome a rendu le code et les poids publiquement accessibles, et propose une interface facilitant l’adoption par la communauté scientifique. Reste à voir comment celle-ci s’emparera de cet outil : sera-t-il utilisé comme une « boîte noire » pratique, ou inspirera-t-il un véritable changement de paradigme en génomique computationnelle ?


Cet article a bénéficié de discussions avec Arnaud Liehrmann, post-doctorant au laboratoire de Biologie computationnelle, quantitative et synthétique.


Tout savoir en trois minutes sur des résultats récents de recherches commentés et contextualisés par les chercheuses et les chercheurs qui les ont menées, c’est le principe de nos « Research Briefs ». Un format à retrouver ici.


The Conversation

Elodie Laine est membre junior de l’Institut Universitaire de France. Elle a reçu des financements de l’Agence Nationale de la Recherche (ANR, France 2030, PostGenAI@Paris, ANR-23-IACL-0007) et de l’Union Européenne (ERC, PROMISE, 101087830). Les points de vue et opinions exprimés sont toutefois ceux des auteurs uniquement et ne reflètent pas nécessairement ceux de l’Union européenne ou du Conseil européen de la recherche. Ni l’Union européenne ni l’autorité octroyant la subvention ne peuvent en être tenus responsables.

Julien Mozziconacci est professeur au Muséum National d’Histoire Naturelle et membre junior de l’Institut Universitaire de France. Il a reçu des financements de l’Agence Nationale de la Recherche (ANR, France 2030, PostGenAI@Paris). Les points de vue et opinions exprimés sont toutefois ceux des auteurs uniquement et ne reflètent pas nécessairement ceux des instituts qui les ont financés.

ref. AlphaGenome, une nouvelle avancée en intelligence artificielle pour explorer les effets des mutations génétiques – https://theconversation.com/alphagenome-une-nouvelle-avancee-en-intelligence-artificielle-pour-explorer-les-effets-des-mutations-genetiques-275833

En France, les personnes âgées consomment trop de benzodiazépines, et en méconnaissent les risques

Source: The Conversation – in French – By Sylvain Pichetti, Économiste de la santé – directeur de recherche, Institut de recherche et documentation en économie de la santé (Irdes)

La France est l’un des pays d’Europe où la consommation de benzodiazépines par les personnes âgées reste la plus élevée. Pour mieux dormir ou calmer l’anxiété, nombre d’entre elles s’en voient prescrire pendant des mois, voire des années, souvent sans que la mesure des risques associés à ces médicaments ne soit prise.

––––––––––-

En France, la prescription de benzodiazépines chez les personnes âgées est particulièrement élevée par rapport à celle observée dans les autres pays de l’OCDE. Ces médicaments voient pourtant leur efficacité diminuer avec le temps et exposent les seniors à de nombreux effets indésirables : risque accru de chutes et de fractures, troubles de la mémoire et des fonctions cognitives, ou encore dépendance.

Face à ces risques, l’Agence nationale de sécurité du médicament et des produits de santé (ANSM) a lancé en avril 2025 une nouvelle campagne d’information visant à promouvoir le bon usage des benzodiazépines et à réduire leur consommation.

Trois études récentes menées par l’Institut de recherche et documentation en économie de la santé (Irdes) permettent de caractériser l’évolution de la consommation en France au cours des dernières années, d’identifier les situations les plus à risque de prescriptions potentiellement inappropriées et de mieux comprendre les leviers susceptibles de réduire ces prescriptions chez les seniors.

Voici ce qu’il faut en retenir.

Une consommation en baisse, mais toujours élevée en France

En France, la consommation de benzodiazépines chez les personnes âgées diminue, mais reste nettement plus élevée que dans la plupart des pays européens. Nos travaux révèlent qu’en 2022, 13 % des personnes âgées de 65 ans et plus ont reçu au moins une prescription potentiellement inappropriée de benzodiazépines au cours de l’année, soit une baisse de quatre points par rapport à 2012. Cette diminution s’inscrit dans une tendance observée dans l’ensemble des pays européens sur la même période.

Plusieurs politiques publiques ont contribué à cette évolution, notamment le ciblage des prescriptions potentiellement inappropriées de benzodiazépines dans la rémunération sur objectifs de santé publique (depuis 2012), la baisse du remboursement de certaines molécules et la diffusion de recommandations de bonnes pratiques par la Haute Autorité de santé (HAS), en particulier pour les troubles de l’anxiété et du sommeil. La HAS précise par ailleurs qu’en cas de prescription, la planification d’emblée de la stratégie de déprescription s’avère nécessaire afin que le traitement ne dépasse pas trois mois.

Malgré ces efforts, la France reste un pays à forte consommation : les prescriptions potentiellement inappropriées y sont environ deux fois plus fréquentes qu’en Suède et six fois plus qu’au Danemark.

Dans notre pays, la consommation de benzodiazépines varie fortement selon les territoires. Les taux de prescription les plus élevés, autour de 23 %, sont observés dans certaines régions comme la Bretagne, les Hauts-de-France, le Limousin, la Champagne-Ardenne, la Gironde ou le littoral sud, alors que la moyenne des zones de faible prescription s’établit autour de 14 %.

L’analyse des données indique que les bassins de vie dans lesquels les personnes âgées appartiennent plus souvent à la catégorie sociale des employés ou des ouvriers ont des taux standardisés de prescriptions potentiellement inappropriées de benzodiazépines plus importants. En outre, l’offre de soins, accessible dans les bassins de vie, joue aussi un rôle. Une meilleure accessibilité aux médecins généralistes, principaux prescripteurs, est associée à plus de prescriptions potentiellement inappropriées.

Deux types de prescriptions inappropriées chez les personnes âgées

Chez les personnes âgées, deux configurations de prescriptions sont considérées comme potentiellement inappropriées.

La première renvoie à la prescription de benzodiazépines à longue durée d’action. Ces médicaments qui mettent plus de temps à être éliminés par l’organisme sont très fortement déconseillés pour les personnes âgées de 65 ans et plus. En effet, avec l’âge, les fonctions hépatiques et rénales diminuent, ce qui allonge le temps d’élimination des médicaments. En raison de la sédation, de la faiblesse musculaire, de la confusion, les benzodiazépines augmentent le risque de chutes, qui sont une cause majeure de fractures du col du fémur et d’hospitalisation chez les personnes âgées.

La deuxième configuration porte sur la durée de prescription qui ne doit pas dépasser trois mois chez le sujet âgé, selon les recommandations nationales (Haute Autorité de santé) et internationales (American Society of Addiction Medicine).

Le rôle central du médecin généraliste dans la prescription

En France, les médecins généralistes sont à l’origine de plus de 80 % des prescriptions de benzodiazépines. Ils connaissent les risques chez les patients âgés grâce aux recommandations diffusées par la Haute Autorité de santé. Pourtant, la pratique de prescription varie beaucoup d’un médecin à l’autre.

En tenant compte des différences de sexe, d’âge, de mortalité et de pathologies de leurs patients, certains médecins généralistes affichent seulement 10 % de prescriptions potentiellement inappropriées de benzodiazépines en 2015, tandis qu’elles dépassent 30 % chez d’autres confrères.

Les médecins qui ont les taux de prescription les plus élevés et qui conservent ce niveau dans le temps (entre 2015 et 2022) sont plus âgés et plus souvent des hommes. Au contraire, les médecins femmes réduisent plus souvent leurs prescriptions, quel que soit leur niveau initial de prescription.

Concernant la différence de prescription selon l’âge des médecins, l’argument avancé est que la proximité avec l’âge des études explique un meilleur respect des recommandations de bonne pratique, et donc une meilleure prescription. Les plus jeunes médecins prescrivent donc mieux que les médecins plus âgés. Pour la différence liée aux genres, les femmes médecins semblent accorder une attention particulière au respect des recommandations de bonnes pratiques.

Un point à souligner est que certaines populations vulnérables, comme les personnes atteintes de troubles psychiques ou de maladies neurodégénératives, ne bénéficient pas de la baisse de prescription observée entre 2012 et 2022, contrairement aux personnes âgées atteintes d’autres pathologies.

De plus, pour ces patients, les niveaux de prescriptions potentiellement inappropriées de benzodiazépines sont déjà parmi les plus élevés, compris entre 30 % et 50 %. Or, ils peuvent avoir une capacité réduite à consentir à ces traitements.

La relation médecin-patient-aidant influe sur la décision de prescrire

Avec la dégradation de l’état de santé des personnes âgées et l’apparition de maladies neurodégénératives, telles que la maladie d’Alzheimer, le maintien à domicile repose le plus souvent sur la présence d’aidants familiaux, qui sont amenés à coordonner les soins de leurs proches.

Ils prennent en charge les rendez-vous médicaux, participent aux consultations et aident à la prise des médicaments. Ils jouent aussi un rôle clé en transmettant au médecin des informations précieuses sur l’état de la personne âgée, par exemple sur l’anxiété, les troubles du sommeil et les troubles comportementaux associés à l’évolution de la maladie.




À lire aussi :
Burn-out et fardeau des aidants : de quoi parle-t-on exactement ?


Nos travaux révèlent que la présence d’un aidant familial pour les démarches médicales est associée à une augmentation de la probabilité de recevoir des prescriptions potentiellement inappropriées de benzodiazépines à longue durée d’action (+ 21,7 points).

Les prescriptions sont plus fréquentes quand l’aidant partage, et donc observe, le quotidien de la personne âgée, parce qu’il est en couple ou cohabite avec elle. Le médecin, bien qu’informé de la nocivité des benzodiazépines, peut être amené à en prescrire lorsqu’aucune alternative n’apparaît envisageable face à des situations d’urgence décrites par l’aidant familial, qui appellent une décision immédiate.

Ces situations d’urgence peuvent prendre plusieurs formes : agitation nocturne intense qui peut conduire la personne âgée à chercher à sortir du domicile et mettre ainsi sa sécurité en jeu, une insomnie totale sur plusieurs nuits qui épuise à la fois la personne âgée et l’aidant, une agressivité soudaine se traduisant verbalement ou physiquement, mettant en difficulté l’aidant qui ne parvient plus à gérer la situation.

Si la relation médecins-aidants-patients a une influence sur la prescription de benzodiazépines, notre étude révèle que l’entrée des personnes âgées en Ehpad est elle aussi associée à un risque de prescription inappropriée.

Les prescriptions potentiellement inappropriées augmentent à l’entrée en Ehpad

L’entrée en établissement d’hébergement pour personnes âgées dépendantes (Ehpad) constitue une période de transition souvent difficile pour les personnes âgées, en particulier celles atteintes de troubles neurodégénératifs.

En France, près d’un résident sur deux en Ehpad présente une prescription potentiellement inappropriée de benzodiazépines. Cette fréquence élevée s’explique par plusieurs facteurs indépendants de l’établissement, tels que l’état de santé souvent dégradé des résidents, ainsi que par les pratiques de prescription des médecins.

À l’admission, certains résidents conservent leur médecin traitant, tandis que d’autres en changent, notamment pour s’adapter à l’organisation de l’établissement ou en raison de l’éloignement géographique avec leur médecin d’origine. Or, les médecins peuvent avoir avoir différentes façon de prescrire, leurs caractéristiques (âge, sexe, exercice solitaire ou en groupe notamment) peuvent avoir un impact important sur leurs prescriptions.

Toutes choses égales par ailleurs, la probabilité de recevoir des prescriptions potentiellement inappropriées de benzodiazépines augmente de dix points après l’entrée en Ehpad.

Cette hausse est principalement portée par les prescriptions chroniques d’anxiolytiques, en lien avec l’apparition ou le renforcement des troubles anxieux à l’occasion de l’admission en Ehpad qui constitue une période très perturbante pour les personnes âgées.

Soulignons toutefois que l’impact de l’admission varie selon le type d’établissement : l’augmentation des prescriptions inappropriées est en effet plus limitée dans les Ehpad du secteur public hospitalier. Par ailleurs, les prescriptions de benzodiazépines sont moins fréquentes dans les établissements où la proportion d’infirmières au sein du personnel soignant est plus élevée. Lesdites infirmières, notamment l’infirmière cadre, jouent un rôle central de coordination des soins médicaux, notamment avec les médecins traitants de ville responsables du suivi médical des résidents.

Mieux informer, et de développer des alternatives non médicamenteuses

On l’a vu, une forte hétérogénéité de prescription persiste selon l’âge et le genre des praticiens. Ce constat plaide pour un renforcement de l’information sur la nocivité des benzodiazépines à destination de l’ensemble des médecins généralistes, afin de mieux les sensibiliser à cette problématique.

Plus largement, il conviendrait d’informer l’ensemble de la population française aux risques liés à l’usage prolongé des benzodiazépines. Cette information permettrait de sensibiliser aussi les aidants familiaux, qui n’ont souvent pas conscience des conséquences négatives de ces prescriptions pour la personne aidée, et qui considèreraient différemment ces prescriptions s’ils en connaissaient les effets sur le long terme.

Un autre levier d’action est de privilégier en première intention les approches non médicamenteuses. Ces alternatives sont déjà disponibles : l’adaptation du logement de la personne âgée (barres d’appui, tapis antidérapant…) pour faciliter ses déplacements et ainsi réduire l’anxiété liée à la peur de tomber ; la pratique d’une activité physique adaptée permettant la relaxation, le recours au psychologue ou à des thérapies cognitivocomportementales pour réduire l’anxiété.

Cependant, face à la diversité des alternatives thérapeutiques non médicamenteuses existantes, une labellisation des alternatives à l’efficacité scientifiquement démontrée apparaît nécessaire, afin de faciliter leur prescription par les médecins.

Enfin, dans les Ehpad, une évaluation systématique des traitements médicamenteux dans les six mois qui suivent l’entrée dans l’établissement, et une diffusion de la culture gériatrique au-delà des Ehpad publics hospitaliers, constitueraient deux pistes d’amélioration pour freiner les prescriptions potentiellement inappropriées de benzodiazépines.

The Conversation

Sylvain Pichetti, dans le cadre de son activité de chercheur à l’Irdes a reçu des financements de l’Institut pour la Recherche en Santé Publique (Iresp) dans le cadre de réponse à appels à projets.

Anne Penneau et Marc Perronnin ne travaillent pas, ne conseillent pas, ne possèdent pas de parts, ne reçoivent pas de fonds d’une organisation qui pourrait tirer profit de cet article, et n’ont déclaré aucune autre affiliation que leur poste universitaire.

ref. En France, les personnes âgées consomment trop de benzodiazépines, et en méconnaissent les risques – https://theconversation.com/en-france-les-personnes-agees-consomment-trop-de-benzodiazepines-et-en-meconnaissent-les-risques-275726

From Harold Wilson to Liz Truss – what the fates of former prime ministers can teach Keir Starmer

Source: The Conversation – UK – By Martin Farr, Senior Lecturer in Contemporary British History, Newcastle University

Despite his name – honouring Keir Hardie, the first leader of the Labour party – Keir Starmer is not known to be a student of political history. This apparent incuriosity helps define an indistinct political identity.

Asked which premier inspires him, Starmer cites Harold Wilson, an unusual choice – Attlee is much more revered in Labour – and superficially surprising. No politician was more political than Wilson: the moment a camera appeared his usual cigar and brandy was replaced with a pipe and a pint. But recent events have demonstrated that Starmer has reason to choose the man who was Labour prime minister twice in the 1960s and 1970s.

Wilson had been soft left, but in Downing Street was non-ideological, tricksy, and reactive. This was partly why he was subject to frenzied speculation about being toppled in office. Labour’s performance in the May 1968 local elections was catastrophic. The following day The Daily Mirror – Labour’s champion – extraordinarily called for Wilson’s removal: he had “lost all credibility: all authority”. Wilson was thereafter beset by rumours of coups. He was a suspicious person, and with reason.

When Anas Sarwar, leader of Scottish Labour, extraordinarily called for Starmer’s removal, the similarities were uncanny. Wilson was defiant: “I know what is going on; I am going on.” Starmer, too, went on, if without the wit.

Resignations and defenestrations

There have been 26 prime ministers since 1900. Nine were removed by voters: Arthur Balfour 1905, Stanley Baldwin 1929, Winston Churchill 1945, Clement Attlee 1951, Ted Heath 1974, James Callaghan 1979, John Major 1997, Gordon Brown 2010, and Rishi Sunak in 2024. Heath is the last to have won and lost power through general elections alone.

The British constitution requires nothing of a premier other than, effectively, that they can command a majority in the House of Commons. A century ago, the prime minister’s constitution was the issue. The Marquess of Salisbury in 1902, Henry Campbell-Bannerman in 1908, and Andrew Bonar Law in 1923 retired on grounds of health: all died within a year. Standing down in 1935, Ramsay MacDonald survived for two. Anthony Eden in 1957, and Harold Macmillan in 1963, cited health but their infirmity was political. Both lived for decades.

David Cameron alone resigned on a point of principle (Brexit). Baldwin, who resigned in 1923 over trade policy, is the closest comparison (though he returned to No 10 twice, and, in 1937, was able to exercise that most rare act of political instrumentality and retire on his own terms). Part of Starmer’s definitional equivocacy is that it’s hard to imagine a point of principle on which he would resign.

Keir Starmer giving a speech.
Labour does not tend to topple its leaders – and Starmer has survived an attempt.
Number 10/Flickr, CC BY-NC-ND

Being toppled in office happened to Herbert Asquith in 1916, David Lloyd George in 1922, Neville Chamberlain in 1940, and Margaret Thatcher in 1990. Asquith and Chamberlain were casualties of wartime coalition politics (Conservatives would not serve under Asquith; Labour would not serve under Chamberlain; Asquith was the more upset).

The Conservatives simply withdrew from supporting Lloyd George. Their 1922 Committee, which was formed as part of this action, was in part, and in effect, an institutionalisation of toppling. These days MPs can submit letters of no confidence to the 1922 Committee, and a ballot is triggered when 15% of them have.

Thatcher, dominant for a decade, overnight was rendered mortal by the concerted action of discontented former colleagues. This failed but it provided the pretext for another – Michael Heseltine – to mount a challenge. Unlike Starmer’s Downing Street operation, Thatcher’s team was slow and complacent. She beat Heseltine, but too narrowly; she resigned.

John Major prevailed, and he, singularly, later invited toppling. After incessant speculation about his leadership of both party and country, in June 1995, he invited his critics to “put up or shut up”. They did the former but Major survived. Starmer is unlikely to repeat the escapade.

Major’s successor, Tony Blair, occupies an intermediate category, being pressured (by the unique power dynamic with his chancellor Gordon Brown) to offer a date – a year hence – when he would stand down. If political pressure becomes too great, this may be the precedent for Starmer. It offers the appearance of agency.

The era of short tenure

Toppling has of late become rather à la mode. Theresa May in 2019, Boris Johnson in 2022, Liz Truss 49 days later. Since Cameron no premier has lasted three years. Starmer looks unlikely to break that record. Yet although MPs are much more rebellious than they used to be, two factors increasingly act to discourage them from toppling.

The first is that Britain has a parliamentary, rather than a presidential, system. Prime ministers are not elected, as such. Oppositions always call for elections when the government changes leader – they chose not to do so when in office themselves (Baldwin again, in 1923, is the closest to an exception). But in an age of electoral disengagement, the idea of an MP moving into 10 Downing Street without the benediction of voters is becoming increasingly untenable.

The second factor is who chooses. There have been three stages as to which successor kisses the monarch’s hand: Asquith and Macmillan became prime minister merely by general party assent; Callaghan and Major after their MPs voted; today that decision ultimately is of party members. Thus Truss. Her experience – and the country’s – may act to concentrate the minds of MPs tempted to topple.

Labour, significantly, has never toppled a prime minister. It’s not in the culture of so cooperativist a party: there’s no equivalent of the 1922 Committee. And whenever it might have happened, the challenger blinked: Herbert Morrison with Attlee; Roy Jenkins with Wilson; David Miliband with Brown; Wes Streeting may have just joined the roster of the rueful. Wilson more than merely survived his near-death experience: he lived to lead Labour into three more general elections, winning two, before emulating Baldwin and retiring on his own terms, in 1976.

And so Starmer’s affinity becomes clearer. Above all, like Wilson, Starmer is dogged. There is however, a profound difference. Wilson, strategically ineffectual, was tactically brilliant. Starmer has demonstrated a propensity for only the former. May’s local elections are approaching. A Wilsonian prime minister aware of political history might know what the following day’s Mirror may reflect.

The Conversation

Martin Farr does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. From Harold Wilson to Liz Truss – what the fates of former prime ministers can teach Keir Starmer – https://theconversation.com/from-harold-wilson-to-liz-truss-what-the-fates-of-former-prime-ministers-can-teach-keir-starmer-276148

Heritage, desire and diplomacy: why China still values scotch whisky

Source: The Conversation – UK – By Qing Wang, Professor of Marketing and Innovation, Director, Marketing Innovation and The Chinese and Emerging Economies (MICEE) Network, Warwick Business School, University of Warwick

maeching chaiwongwatthana/Shutterstock

For more than a decade, China has been one of the most important growth engines for western luxury brands. From fashion and watches to fine wines and spirits, rising incomes and global exposure have fuelled an extraordinary appetite for premium products.

Scotch whisky has been a major beneficiary. Between 2019 and 2023, exports to China surged in value from under £90 million to more than £235 million. But sales have fallen for three consecutive years, while inflation, rising costs and trade tensions have squeezed margins. Now, exports may benefit once again after China halved tariffs on scotch from 10% to 5%.

The sales slowdown reflects a maturing market in which Chinese consumers are becoming more selective, more knowledgeable and more demanding. This is leading to a shift from volume to value, from older to younger consumers, and from conspicuous to considered consumption. These trends help explain both the recent downturn and the sector’s longer-term resilience.

After the height of the COVID pandemic, when economic confidence weakened in China, luxury consumption adjusted, with consumers buying fewer items but investing more carefully.

This pattern is clearly visible in whisky. While overall volumes have fallen, it continues to benefit from “premiumisation” – sustained interest in aged single malts, limited editions and iconic distilleries.

A young, educated whisky culture

Unlike western markets, where whisky has traditionally been associated with older drinkers, China’s core whisky consumers are young. The typical whisky drinker is gen Z: urban, affluent, well-educated and often well-travelled internationally.

A new generation has reframed whisky as a form of cultural capital, with tasting, collecting and investing in casks becoming increasingly common. Single-malt brands such as Glenfiddich and The Macallan have thrived in this environment, with data showing that their market share has tripled since 2019.

China is the ninth largest market for UK whisky exports. In 2024, the UK accounted for 85.6% of China’s whisky imports by value – most of this is scotch. For Chinese consumers, luxury has long been tied to authenticity and provenance. In premium spirits, this logic is particularly powerful.

In China, the value of most western luxury brands is underpinned by their history, heritage, craftsmanship and distinctive cultural narratives. Here, “country of origin” functions as a powerful source of authenticity and uniqueness.

This is especially pronounced in scotch whisky, where the product category is intimately associated with Scotland’s landscape, climate and production traditions. A stringent regulatory system legally defines where, how and under what conditions scotch can be produced, matured and bottled. For Chinese consumers seeking symbolic reassurance of quality and legitimacy, “Scottishness” itself operates as a brand asset.

Even as international firms invest in distilleries inside China, Chinese whisky has not displaced demand for imported scotch. Instead, it has sharpened distinctions between “original” and “localised” products. In business and social contexts, prestigious scotch still functions as a form of social currency, signalling trust, respect and global sophistication.

display cabinet in an airport duty free lounge of scottish single malt whiskies
Chinese consumer culture is changing – but Scottish single malts remain in demand.
TY Lim/Shutterstock

China’s wider luxury market has softened since 2023, with sales falling by up to 20% in some categories. Economic uncertainty exacerbated by geopolitics, a downturn in house prices and subdued consumer confidence have reshaped spending priorities for Chinese consumers.

At the same time, values are changing. Younger consumers are moving away from overt displays of wealth towards more subtle expressions of taste, focusing on experiences and cultural capital. In whisky, this is reflected in a “drink less, drink better” mindset. Consumers are trading down from ultra-premium bottles towards high-quality but more accessible options, mirroring broader shifts in China’s luxury landscape.

Whisky diplomacy

This recalibration of consumption is unfolding alongside renewed trade diplomacy. The deal to halve tariffs came during the UK prime minister Keir Starmer’s state visit to Beijing following nearly eight years of strained relations between the countries.

In premium alcohol markets, tariff changes like these are highly significant, directly affecting overall costs, distributor incentives and the price paid by the consumer.

But the visit mattered for more than economic reasons. For many Chinese consumers of British heritage brands, there is a strong emotional and cognitive appreciation of the country’s traditions, aesthetics and lifestyle – an expression of the UK’s soft power. However, political mistrust between the UK and China could chip away such “soft power” in the minds of Chinese consumers if it remains unresolved.

In this context, Starmer’s visit came to symbolise renewed mutual interest and long-term commitment. Such diplomatic signals can shape consumer sentiment, reinforcing perceptions of openness, legitimacy and stability. For British luxury brands, this symbolic reassurance may be almost as important as tariff reductions in sustaining the trust and loyalty of Chinese consumers.

More broadly, the agreement highlights why a constructive UK–China relationship matters for the scotch industry. Whisky supports distilling, agriculture, packaging, logistics, tourism and rural employment in the UK. Maintaining access to China’s premium segment is vital for sustaining investment and skills.

Following the boom years, China’s relationship with western luxury brands is entering a more stable and disciplined phase. For scotch whisky, rarity, provenance and authenticity remain powerful assets. As long as producers adapt to China’s more discerning consumers – and are supported by constructive trade relations – the long-term outlook looks positive. In a world of oversupply and shrinking margins, China’s cautious connoisseurs may yet prove to be among scotch’s most valuable allies.

The Conversation

Qing Wang does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Heritage, desire and diplomacy: why China still values scotch whisky – https://theconversation.com/heritage-desire-and-diplomacy-why-china-still-values-scotch-whisky-275971

Ostarine: the performance-enhancing drug giving anti-doping agencies a headache

Source: The Conversation – UK – By Tom Bassindale, Head of School, Biosciences and Chemistry, Sheffield Hallam University

Shutterstock AI/Shutterstock.com

A drug designed to help cancer patients rebuild wasting muscles has become one of the most contentious substances in elite sport – and the scientist who discovered it now spends more time trying to stop people using it than encouraging its medical use.

James Dalton, who developed ostarine in the early 2000s, recently told the New York Times: “I spend more time now trying to stop people from using it than trying to get people to use it.” His frustration highlights a growing crisis in anti-doping, where even innocent athletes are testing positive for a drug that can be transferred through sweat or contaminated supplements.

Ostarine belongs to a class of drugs called selective androgen receptor modulators, or Sarms. Dalton and his team created these compounds as a safer alternative to traditional steroids for treating muscle wasting, osteoporosis, frailty and other conditions linked to ageing. Unlike steroids, which must be injected, Sarms can be taken as tablets or capsules, making them far easier to use.

The appeal was obvious. Traditional anabolic steroids do build muscle – the anabolic effect – but they also trigger unwanted male sexual characteristics. These include body hair growth, aggression, male pattern baldness, acne and breast tissue development in men. Women who abuse steroids can experience voice deepening and menstrual changes.

Sarms were meant to deliver only the muscle-building benefits without these side-effects. Ostarine, also known as enobosarm, showed particular promise for lung cancer patients losing muscle mass. More recently, researchers have investigated whether it could prevent muscle loss in people taking weight-loss drugs like Wegovy, where significant muscle is often lost alongside fat.

Despite this potential, no Sarm has passed the clinical trials needed for medical approval. There are concerns the drugs may cause liver damage, as reported in some users. Ostarine remains unapproved for human use more than two decades after Dalton’s initial research was published.

This hasn’t stopped it reaching athletes. When Dalton’s team published their work, the chemical structure became public knowledge. Black market manufacturers seized the opportunity, packaging ostarine as a sports supplement. Because selling Sarms as supplements is illegal, they’re often labelled “for research purposes” or “not for human consumption” – a transparent attempt to skirt regulations.

The World Anti-Doping Agency (Wada) recognised the abuse potential early, adding Sarms to its prohibited list in 2008. On the 2026 Wada prohibited list, ostarine appears under “S1.2 Other Anabolic Agents”, banned at all times in all sports.

Complicated and unfair

The problem has escalated dramatically. Over the past two years, ostarine has become the most commonly detected Sarm in Wada laboratories, appearing in 114 athlete samples. But here’s where things get complicated – and deeply unfair – for many athletes.

Sport operates under strict liability. Athletes are responsible for any banned substance found in their samples, regardless of how it got there. Even unintentional contamination can result in a ban.

The quality control of many supplements is poor, meaning products can contain traces of ostarine without declaring it on the label. The US Anti-Doping Agency maintains a list of high-risk supplements, with ostarine appearing undeclared in 19 products.

Athletes hoping to challenge a positive test must have kept the supplement and pay for independent testing – an expensive process with no guarantee of success. Sports authorities strongly recommend athletes only use supplements batch-tested by Informed Sport or NSF Certified for Sport – organisations that verify products are free from contamination.

Ostarine can also transfer between people. Athletes have successfully argued their positive tests resulted from sharing equipment. In one recent case, an athlete proved ostarine could transfer through a sweaty neoprene support shared with another athlete. Officials accepted the transfer explanation and dropped the charges.

Other cases have shown the drug can pass through bodily fluids like saliva.

This creates a profound dilemma for anti-doping authorities. Modern laboratory equipment is extraordinarily sensitive, capable of detecting minute quantities of drugs. But a urine test cannot distinguish between someone who deliberately took a large dose, someone who unknowingly consumed a contaminated supplement, or someone who absorbed traces through contact with another person’s sweat.

A sweating female athlete.
Ostarine can be transferred via sweat.
PeopleImages/Shutterstock.com

The burden of proof falls entirely on the athlete. They must explain why a banned substance is in their system, often at considerable personal expense. This same problem affects all Sarms, not just ostarine.

Dalton himself is now trying to solve the mess his discovery helped create. As co-chair of the Scientific Advisory Board of the Partnership for Clean Competition, he’s funding research into sports drug testing. The group’s priority is finding ways to differentiate between contamination and deliberate doping.

The hope is to identify marker compounds in urine that could definitively show whether a positive test resulted from intentional use or inadvertent contamination. Such a breakthrough would spare innocent athletes the ordeal of proving their innocence while still catching genuine cheaters.

Until then, a drug designed to help the sick continues to threaten the careers of athletes who may never have chosen to take it – and the scientist who created it remains caught in the middle, fighting against the unintended consequences of his own research.

The Conversation

Tom Bassindale does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Ostarine: the performance-enhancing drug giving anti-doping agencies a headache – https://theconversation.com/ostarine-the-performance-enhancing-drug-giving-anti-doping-agencies-a-headache-275353

Curious kids: why don’t humans have tails?

Source: The Conversation – UK – By Mark Grabowski, Senior Lecturer of Biological and Environmental Sciences, Liverpool John Moores University

Natalia Deriabina/Shutterstock

Why don’t humans have tails anymore?

Olivia, 12 , the Netherlands.

Great question, and it gets to the heart of what we are as humans.

Think about your own family – do you have cousins? If so, you and your cousins share grandparents and these are your common ancestors.

Now imagine going back further in time. You and your more distantly related relatives also share common ancestors from longer ago, which you can see on your family tree. And when you look around the world, all living things also share a single common ancestor, which lived between 3 and 4 billion years ago.


Curious Kids is a series by The Conversation that gives children the chance to have their questions about the world answered by experts. If you have a question you’d like an expert to answer, send it to curiouskids@theconversation.com and make sure you include the asker’s first name, age and town or city. We won’t be able to answer every question, but we’ll do our very best.


Life on Earth is a really big family tree. That means dogs and cats are related, but also you and squirrels, you and fish, and you and the dinosaurs. Everything alive today and that ever was alive is descended from that same original ancestor.

Four billion years is not something we can really visualise in our heads. To give an idea of how long ago this was, a billion golf balls would fill a large train station. So think of four of these – that is a lot of golf balls, and a long time ago.

Zooming in to more recent times, we are apes. We share common ancestors with the other living apes – chimpanzees and gorillas, orangutans and gibbons. And while chimpanzees and gorillas have many features in common, chimpanzees and humans are sister species. This means we are more closely related to each other than any other living species.

This also means a lot has happened (evolution) in the human lineage since we shared this common ancestor. Our anatomy has changed substantially, allowing us to walk upright, use tools, speak, and other features that make us the successful species we are.

Monkey toy climbing a pillar.
Humans are closely related to monkeys.
Farewell love/Shutterstock

However, all apes including us are united by several features. All apes have large brains, for example, though ours is the largest. And all apes have a body plan that allows us to take an upright posture – our chests are much more vertical than a dog’s or even a monkey’s.

We also have a particular pattern of grooves in our lower molar teeth – the five bumps you can feel there are arranged in a Y-shape (known as Y-5 pattern). This is only found in apes.

Finally, all apes climb trees and suspend themselves from branches. We still have features of our arms and shoulders that allow us to do this safely.

We have these because we descended from a single common ape ancestor, probably around between 20 and 30 million years ago. Using
our golf ball image, a million golf balls would fit into a large bedroom, so imagine 30 large bedrooms of golf balls and you get some idea of how long ago that was.

Our current best evidence of what this common ancestor of apes looked like is based on fossils – the remains of once-living creatures that have been transformed into rock.

When we look at this current best evidence – such as in the extinct species Ekembo heseloni from Africa – we see a species that is actually fairly monkey-like. It climbed trees but may not have swung below branches – instead walking on top of them. This is quite surprising, as all living apes share features that allow us to swing from branches.

However, we know it was an ape because of two main features. First, it has that distinctive Y-5 pattern in its lower molars, just like you do. Second, it lacks a tail. Lacking a tail is a distinctive feature of all apes.

Why do all apes lack a tail?

We only have hypotheses (informed guesses) as to why our common ancestor didn’t possess a tail. This is because most other primate groups, both living and extinct, do have a tail.

Blond girl hangs from monkey bars.
The natural urge to monkey around.
Nataliabiruk/Shutterstock

One suggestion is that when the earliest apes shifted to more upright postures and other changes in the way they moved around in trees, their tail became less helpful. So perhaps evolution caused the muscles that had previously been used for tail attachments to instead become part of the pelvic floor.

The pelvic floor is made of the muscles at the base of the spine that help your internal organs resist gravity – keeping them inside your body rather than falling out. That is a pretty important function, as you can imagine.

Another suggestion is that tails disappeared from the earliest apes due to a genetic mistake. When a single short stretch of DNA found in humans and other apes, but not in other primates, was added to mice in a 2024 study, it caused the mice to develop only minimal or no tails.

So, despite how amazing having a tail would be to us now, our ancestors may have lost it due to them no longer needing it – or simply because of a chance mistake.

The Conversation

Mark Grabowski does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Curious kids: why don’t humans have tails? – https://theconversation.com/curious-kids-why-dont-humans-have-tails-275716