Category: MIL-OSI

Source: The Conversation – USA – By Mehrzad Boroujerdi, Vice Provost and Dean of College of Arts, Sciences, and Education, Missouri University of Science and Technology

It has been said that trust is like glass: Once it is shattered, nothing will ever be the same. In the case of the enduring hostility between the Islamic Republic of Iran and the United States over the past 47 years, even this metaphor may be an understatement.

The tone of the relationship is indicative of this fact.

In 2020, Iran’s supreme leader denounced President Donald Trump as a “clown” who only pretends to support the Iranian people while ultimately plunging a “poisonous dagger” into their backs.

And in a U.S. version of this hostility, Trump’s special envoy Steve Witkoff said on Feb. 23, 2026, about the president’s approach to Iran: “I don’t want to use the word ‘frustrated,’ because he understands he has plenty of alternatives, but he’s curious as to why they haven’t … I don’t want to use the word ‘capitulated,’ but why they haven’t capitulated.”

The war that began on Feb. 28, 2026, hews to a familiar but dangerous pattern. Deep, historical mistrust, incompatible strategic interests, domestic political constraints on both sides, miscommunication and misperception, zero-sum thinking and repeated diplomatic overreach gradually pushed the relationship between Iran and the U.S. toward open conflict.

Rhetoric, not reality

When Tehran refused to yield to Trump’s demands, he described Iranian leaders in blunt terms: “They’re sick people. They’re mentally ill. Sick people. They are angry. They are crazy. They are sick.”

For a deeper understanding of Iran, policymakers in Washington could have looked to the insights of John W. Limbert, a distinguished diplomat with four decades of experience in Iranian affairs and a hostage during the Iran hostage crisis.

In 2008, as part of a U.S. Institute of Peace study of Iranian negotiating style, Limbert outlined 15 principles for Americans seeking successful negotiations with Iranian counterparts. Among his most important observations was that each side tends to assume the worst about the other, viewing its adversary as “infinitely devious, hostile, and duplicitous.”

Little evidence suggests that such hard-earned wisdom has informed recent rhetoric.

Instead, American leaders’ and media’s discussions of Iran over the past few decades have often relied on a familiar narrative: the portrayal of Middle Eastern leaders as irrational or “lunatic” figures − first, revolutionary leader Ayatollah Ruhollah Khomeini, then Saddam Hussein, followed by Moammar Gadhafi, Bashar Assad, and now Ali Khamenei.

This narrative conveniently overlooks inconvenient facts.

Getting to breakdown

It was Trump who withdrew the United States from the 2015 nuclear agreement with Iran during his first term. It was also the United States that during renewed negotiations in 2025 and 2026 chose to bomb Iranian targets twice while talks were still underway.

Nor were the negotiations ever strictly bilateral. There was always an unoccupied chair at the table metaphorically reserved for a ghost participant: Israel. In my view, Prime Minister Benjamin Netanyahu skillfully used political leverage and diplomatic pressure to shape the process publicly and privately.

When it came to Iran, Trump often violated a basic principle of diplomacy: asking Iran to concede without any reciprocity. Meanwhile, Netanyahu would repeatedly move the goal posts − asserting that Iran was on the verge of acquiring a nuclear weapon, insisting it had no right to enrich uranium on its own soil, demanding the dismantling of its nuclear infrastructure, calling for the elimination of its ballistic missile capability, and ultimately advocating regime change.

The extent to which Israeli pressure shaped successive American policies is a question historians and investigative journalists will continue to debate.

Yet responsibility for the breakdown cannot be placed on Washington and Jerusalem alone. Iranian leaders contributed significantly to making the conflict with the United States so intractable.

A corrupt, repressive and economically struggling regime relied heavily on performative anti-American politics for domestic legitimacy. Tehran matched American and Israeli rigidity with intransigence and strategic overreach of its own.

Limiting inspections by the International Atomic Energy Agency, failing to provide credible answers about past nuclear activities, constructing secret facilities and attempting to negotiate from a position of weakness ultimately proved disastrous when dealing with an impatient and impulsive American president.

The unknown unknowns

What comes next?

If regime change does not occur in Tehran, the two sides will almost certainly find themselves negotiating again once the fog of war dissipates.

The hostility between them will not disappear, and diplomatic niceties may become rarer. Yet diplomacy rarely requires trust; it requires interests.

I believe that future talks are therefore likely to be transactional rather than transformational. Technical and legal parameters will still need to be negotiated. Hawks and doves will continue to compete for influence in both capitals.

And the oldest rule of bargaining will remain unchanged: When you lack leverage, acquire it – then negotiate.

Mehrzad Boroujerdi does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. 47 years of deep mistrust and misperception paved the way to war between Iran and the US − and complicate any negotiations – https://theconversation.com/47-years-of-deep-mistrust-and-misperception-paved-the-way-to-war-between-iran-and-the-us-and-complicate-any-negotiations-277789

Source: The Conversation – USA (2) – By Leonardo Macelloni, Director of the Mississippi Mineral Resources Institute and Center for Marine Resources and Environmental Technology, University of Mississippi

You may be hearing a lot lately about critical minerals and rare earth elements. These natural materials are essential to industry and modern technology – everything from cellphones to fighter jets.

They include lithium and cobalt used in batteries, neodymium for magnets in motors and hard drives, and rare earths that are essential in defense systems, lasers and medical imaging. Critical minerals are also indispensable for renewable energy systems, energy storage and digital infrastructure. Without them, modern society – and any realistic path to a world with net-zero emissions – would not be possible.

Critical minerals get their name because they’re also highly vulnerable to supply chain disruptions from global events, trade tensions or economic instability. And, today, one country dominates many critical mineral supply chains: China.

With that in mind, many governments are looking for alternative sources of critical minerals, and several companies are eyeing the ocean floor as a potential new frontier for mining them.

As a marine geologist, I know the potential for seafloor minerals is vast. But that doesn’t mean those minerals are easy to harvest. They come in several forms, from potato-size rocks scattered on the seafloor to seafloor crusts at hydrothermal vents and underwater brine pools. And they are often found in sensitive locations that are home to fragile marine life, raising questions about damage to some of the least explored and least understood parts of our planet.

Polymetallic nodules on the seafloor

When you picture seafloor mining, polymetallic or manganese nodules are probably what come to mind.

Rock-like nodules are about the size of potatoes and are found scattered on vast deep-water plains, typically 3,000 to 6,000 meters deep, in several regions, including a large area of the Pacific Ocean southeast of Hawaii.

They primarily consist of manganese and iron, though they can contain significant amounts of other metals, including valuable nickel, cobalt, copper and small amounts of rare earth elements and platinum.

Nodules form from metals that get into the ocean through erosion or from seafloor hydrothermal vents in volcanically active areas. The metal ions attach to a nucleus, such as a rock or shell fragment. Over time, layers form around that core. The growth is very slow – only a few millimeters in a million years – so larger nodules can be several million years old.

More than 17 exploration licenses exist, primarily in the Pacific’s Clarion-Clipperton Zone. Tests there have involved suctioning nodules from the seafloor to ships above. But, as of early 2026, full-scale, commercial mining has not yet begun.

Seafloor massive sulfides at hydrothermal vents

Another source of critical minerals is seafloor massive sulfides, which form near hydrothermal vents along oceanic ridges. Volcanic activity reacts with seawater, fueling bursts of marine life at these vents, and also forming rocks rich in copper, gold, zinc, lead, barium and silver.

These hot springs form where water rises through the oceanic crust at high temperatures, up to about 750 degrees Fahrenheit (400 degrees Celsius). The metals contained in these solutions precipitate on contact with the cold, oxygen-rich seawater, forming the ventlike structures known as “black smokers” because they look like factory chimneys.

The technology for mining these deposits is currently being built. The first deep-sea tests were performed by Japanese miners in their coastal waters.

Cobalt-rich crusts at seamounts

Ferromanganese crusts are another source. They form on the slopes and summits of underwater mountains known as seamounts and contain manganese, iron and a wide array of trace metals such as cobalt, copper, nickel and platinum.

Over millions of years, metals in the surrounding seawater form coatings of iron and manganese oxides, with thicknesses ranging from a few millimeters to a few decimeters, depending on the age of the seamounts.

Crust mining is technically much more difficult than nodule mining. Nodules sit on soft sediment. Crusts, in contrast, are attached to substrate rock. For successful crust mining, it would be essential to recover the crusts without collecting too much substrate, which would dilute the ore quality.

However, little is known about the marine life found on seamounts, particularly those in the most likely regions for crust exploration and mining.

Underwater brine pools

Another possible ocean source of lithium and potentially rare earth elements may lie in unusual underwater lakes called hypersaline brine pools. These salty pools are found on the seafloor in several parts of the world, but they are especially common in the Gulf of Mexico.

Brine is already the source of much of the lithium used today. Companies extract it from salty water produced during oil and geothermal operations.

Lithium becomes concentrated in brines over millions of years. As water moves through deep rocks, minerals dissolve along the way and elements like lithium can accumulate.

Extracting lithium from deep-sea brines, if it is confirmed to be there, could be more straightforward than traditional seabed mining. Technologies already exist to separate lithium from salty water.

In the Gulf, this approach could potentially use existing offshore oil and gas infrastructure, reducing the need for new construction. The brine could be pumped up, processed to remove lithium, and then returned to the subsurface.

Deep-sea mud

In the Central Pacific Ocean and off Japan, deep-sea mud enriched with rare earth elements and yttrium has been recognized as another new resource.

These deposits form from the very slow accumulation of fish debris, composed of biogenic calcium phosphate, in the deepest parts of the ocean. In 2026, a Japanese research vessel successfully drilled and retrieved deep-sea sediment containing rare earth minerals from the seabed near the island of Minamitorishima, and the Japanese government announced a deep-sea mud extraction trial would begin in 2027.

The drawbacks for marine life

While these regions likely hold vast resources, scientists know very little about the ecological conditions at the boundary between deep-sea water and seafloor sediments, especially about the microbial communities that live there.

Microorganisms are the most widespread and fundamental forms of life on Earth. They play central roles in ecosystems, nutrient cycles, and the long-term stability of the planet. The potential impacts of mechanically removing nodules from the seafloor – through cutting, scraping or lifting – on these microscopic ecosystems remain largely unknown.

In the Pacific Ocean, an experimental mining test carried out in 1978 was revisited more than two decades later. Even after 26 years, tracks left by mining vehicles were still visible on the seafloor. The disturbed areas had fewer bottom-dwelling organisms and less diversity compared to nearby undisturbed regions. Notably, no detailed assessment of microbial communities was conducted, leaving a significant gap in understanding.

Complicating the issue further, many prospective deep-sea mining areas lie in international waters, beyond the jurisdiction of individual nations.

The International Seabed Authority is responsible for regulating mineral activities in the deep ocean, but there is no global consensus on the rules, safeguards or acceptable risks associated with seabed mining. Some countries, including the United States, are discussing creating their own licenses to mine in international areas, while about 40 others are calling for a mining moratorium until the risks are better understood.

Critical minerals are the invisible foundation of modern life. As interest in deep-sea mining grows, these scientific uncertainties and governance challenges will be central to the debate.

Nothing to disclose.

– ref. Mining the ocean floor: 5 deep-sea sources of critical minerals essential to technology, and the fragile marine life at risk – https://theconversation.com/mining-the-ocean-floor-5-deep-sea-sources-of-critical-minerals-essential-to-technology-and-the-fragile-marine-life-at-risk-275804

Source: The Conversation – USA (2) – By Diane Winston, Professor and Knight Center Chair in Media & Religion, USC Annenberg School for Communication and Journalism

The compulsion started soon after my marriage.

Long before e-books and audiobooks, I furtively read paperbacks whose covers of bosomy maidens and bare-chested men would have outed my obsession. Then, on a family car trip, my husband told my young stepdaughters why I liked sitting alone in the back seat.

“Diane is reading bodice rippers,” he said, citing the old-fashioned name for sexually explicit romance novels. Back then, they were my guilty pleasure.

More than 30 years later, I remain a fan of romance novels, but it’s no longer a craving I feel compelled to hide. In fact, I value the window it opens to my research interests in pop culture, religion and gender.

I’m not alone. Romantic fiction makes up almost 25% of books sold in the U.S., and the genre earned US$1.44 billion globally in 2022-23. The Bible may be the bestselling book of all time, but annual sales of romance novels even outpace the Scriptures.

Written by women, for women

Among scholars, there’s a range of opinions on the genre’s enduring popularity.

Some describe romantic fiction as the literary equivalent of Marx’s “opium of the masses.” They argue that these books are perennial bestsellers because they offer escapism and the promise of “happily ever after” – a quick sugar high to distract from the struggles of everyday life.

Other scholars cite the genre’s pedigree. Though they’re canonized as literary classics, 19th-century novels such as “Pride and Prejudice,” “Jane Eyre” and “Wuthering Heights” can also be read as romances – stories written by women and centered on women’s emotional lives, courtship and desires. In a world circumscribed by the era’s narrow gender roles, these books featured clever, often headstrong women who exercised some agency over their love lives and their fates.

In my view, this explains their popularity: 19th-century readers may have found vicarious pleasure in Jane Eyre’s journey from timid governess to independent heiress and happy wife. Likewise, Catherine Earnshaw’s decision to marry the wealthy Edgar Linton, thus abandoning the penniless Heathcliff, may have struck the female fans of “Wuthering Heights” as an understandable choice.

Nineteenth-century women had limited pastimes. Books that reflected on their own circumstances, albeit with more intrigue and drama, were catnip. But as readership grew, male authors wanted to cash in on the expanding market.

As men penned their own novels, their perspectives dominated, pushing women’s fiction to the side. Changing social mores also made the once popular “woman’s novel” seem dated.

The romance genre was revived in the 20th century when authors added more oomph to their plots and edgier characters. Daphne Du Maurier’s 1938 classic, “Rebecca,” breathed new life into gothic romances – love stories set in dreary, desolate places, intermingled with horror and suspense. And Georgette Heyer revitalized historical romance with smoldering stories such as “The Grand Sophy,” set in England’s Regency period (1811–1820).

Bodice rippers debuted in the 1970s. The name came, in part, from the covers, which often depicted a woman in a half-torn dress being embraced by a buff male. A racier take on the romance genre, they were often set in early 19th-century England and ended in happily-ever-afters. But the characters were sexually active in ways that would have shocked and scandalized Jane Austen’s heroines.

Kathleen E. Woodiwiss’ “The Flame and The Flower” (1972) is widely credited with launching the modern bodice ripper: The first romance novel published in paperback, it became a huge bestseller, despite its graphic rape scenes.

These novels, which debuted in the midst of the sexual revolution, were more explicit than their precursors, and heroines enjoyed more agency in their life choices. That said, the sex was male-driven and often implied that a “throbbing member” could send the heroine into paroxysms of ecstasy.

Lovestruck mafiosos and bull breeders

The digital revolution further transformed romance novels.

Self-publishing, digital publishing and BookTok brought new and younger readers into the mix. Anyone could become a romance novelist, leading to an array of new characters, plots and sexual adventures.

A genre that once mainly featured straight, British aristocrats now embraced Black, Latino and Asian protagonists. There were wanton witches, voracious werewolves and vampire lotharios. Some stories explored alien pairings and lovestruck mafiosos, while in others, LGBTQ characters and professional athletes took center stage. Readers drawn to bawdier fare could dive into erotic fiction, with plotlines featuring women mating with bulls, reverse harems – one woman with several men – and women consorting with multi-limbed aliens.

Many of these innovations have something in common. Rather than sticking to the male-driven plotlines of 20th-century bodice rippers, most contemporary romance writers focus on the female orgasm. Men are far less likely to rush penetration because, before seeking their release, they want their partners to experience multiple climaxes.

But contemporary female characters are not just sexually satisfied. They also enjoy successful careers and close female friends. True to real life, some are plus size or have disabilities. Others were burned in past encounters. They need suitors to scale their emotional walls before blowing their minds in the bedroom.

Women in control

Put together, the genre has undergone a 180-degree turn from the books I hid in the 1990s.

Today’s romantic fiction is less about horny couplings and happy endings and more about exploring emotional connections and power dynamics. Stories also play out the impact of race, class, gender and sexuality on relationships.

Consider the bestselling book and breakout hit HBO series “Heated Rivalry,” which explores the complicated romance between two gay hockey players. It’s beloved by straight and gay female fans for depicting a blossoming relationship characterized by emotional vulnerability rather than toxic masculinity. And it reveals a trend previously underreported: Women like watching gay men enjoying sex.

While the “Heated Rivalry” phenomenon is intriguing, readership also has skyrocketed for romantasy.

Romantasy features unconventional women navigating make-believe worlds populated by magic, faeries and dragons. Some heroines are timid, others are brazen, but they share a drive to succeed on their terms.

The genre took off in 2015 with Sarah Maas’ “A Court of Thorns and Roses,” the saga of a beautiful but impoverished teen who finds herself in the faerie court. Eleven years and two series later, Maas’ books have sold more than 75 million copies. Each novel is kinkier than the last, and they’ve even inspired some readers to spice up things in their own bedrooms.

The success of these new romance subgenres reflects a striking societal shift: Women are no longer shy about being on top. As writers and readers increasingly see powerful women in C-suites and boardrooms, they expect similar strength in the bedroom.

Although what women want has not changed over time, our ability to achieve it has. That’s why the popularity of books by, for and about women is as fervent today as when Elizabeth Bennet, the heroine in “Pride and Prejudice,” fell for Mr. Darcy. But Lizzie Bennet lived in a world where she could do only so much, hemmed in like her real-life counterparts.

Thankfully, women today enjoy more power, agency and pleasure. And thankfully, too, we have a lot more books by, for and about women as we contemplate what lies ahead.

Diane Winston does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. From bodice rippers to romantasy, romance novels are dominating the book market – and rewriting women’s sexual power – https://theconversation.com/from-bodice-rippers-to-romantasy-romance-novels-are-dominating-the-book-market-and-rewriting-womens-sexual-power-273765

Source: The Conversation – USA (3) – By Logan Pant, Assistant Professor of Marketing, University of Evansville

Thinking about certain types of alcohol can alter your mood and trigger certain mindsets, especially among young consumers. For instance, tequila calls up a party mindset, whiskey activates a masculine mindset, and wine primes a sophistication mindset.

Those are the key takeaways of a new study my team and I published in the journal Young Consumers.

We carried out four studies with 429 total participants to examine the cultural themes and moods people associate with different types of alcohol.

We conducted two preliminary studies to understand how people think about different types of alcohol. In the first study, participants answered open-ended questions, and in the second they completed a word-association task. These studies helped us identify common cultural associations, which we call “learned associations,” or ideas people develop through experience and cultural exposure.

We used these associations to create questions about alcohol-related mindsets. Participants rated how much they felt different qualities when thinking about a randomly assigned type of alcohol in response to the prompt, “I feel ___ when thinking about this type of alcohol.” For example, the sophisticated mindset included sophisticated, elegant, classy, formal and fancy; the masculinity mindset included masculine, tough, confident, manly and strong; and the party mindset included energetic, outgoing, fun, like partying and like celebrating.

Then we conducted two experiments where participants were randomly assigned to think about either wine, whiskey or tequila and respond to the mindset questions, allowing us to test whether different types of alcohol evoke different associations.

Importantly, participants did not consume alcohol, allowing us to isolate the learned associations these drinks evoke, separate from alcohol’s physiological effects.

Clear patterns emerged. Tequila was frequently associated with words like fun, wild, celebration and party. Whiskey elicited terms such as strong, rugged, confident and masculine. Wine, by contrast, was associated with elegance, class, refinement and sophistication.

These findings show that alcohol can function as a “symbolic cue.” In other words, the mindsets people associate with different drinks appear to originate from learned associations rather than from intoxication itself.

Why it matters

More than half of the U.S. adult population consumes alcohol: 54% in 2025. This is the lowest level recorded since Gallup began tracking the drinking habits of adults in the U.S. in 1939, and it marks a decline from 1997-2023, when over 60% of adults reported drinking.

Some drink to enhance experiences, while others drink for enjoyment, socializing or even escapism. For others, drinking may become compulsive or difficult to control, defined as an alcohol use disorder.

Research increasingly shows that even moderate drinking can carry health risks, including higher risks of several cancers.

A considerable amount of research on alcohol has explored what happens as a result of drinking. Studies have found that people become uninhibited and make risky decisions when they drink. Other researchers have found that people pick up ideas and habits about drinking from the world around them and that advertising can influence what, when and how young people drink.

Fans of the popular sitcom “How I Met Your Mother” might recall an episode titled ‘The Perfect Cocktail.“ In this episode, different alcoholic beverages reflect the personalities of Marshall (Jason Segel) and Barney (Neil Patrick Harris). It’s funny and engaging, but what if there’s a real psychological basis for these associations?

Such learned associations have not been thoroughly studied – in particular, it’s unknown whether they can activate distinct drinking mindsets even without actual consumption.

One reason why this is important is that even though Gen Zers drink less alcohol than previous generations, they are still exposed to alcohol-related media and cultural cues. Understanding these psychological cues may help explain how alcohol-related social norms and expectations develop and influence drinking decisions.

What’s next

Learned associations for different alcoholic drinks can influence how people feel, which in turn might shape their intentions, choices and social expectations. For example, if thinking about tequila prompts a “party” mindset, it could influence how a person plans their evening and what choices they make.

A better understanding of these associations could help public health campaigns promote moderation and responsible drinking, such as pacing drinks, staying hydrated and avoiding overconsumption. Future research could examine how these associations form in different social contexts, how they vary across age groups or cultures, and how interventions might shift them to further reduce risky behaviors and encourage safer, more responsible alcohol consumption.

The Research Brief is a short take on interesting academic work.

This research was funded by the Department of Marketing at the University of North Texas.

– ref. Just thinking about tequila, whiskey or wine shifts your mindset – new research – https://theconversation.com/just-thinking-about-tequila-whiskey-or-wine-shifts-your-mindset-new-research-277160

Source: The Conversation – USA (3) – By Rachel French, Assistant Professor of Family and Community Health, University of Pennsylvania

Patients who are prescribed higher daily doses of the medication buprenorphine for opioid use disorder are significantly more likely to stay in treatment. Those on 17 to 24 milligrams averaged 190 days in care compared to 90 days for those on 8 milligrams or less. Yet Black patients are less likely than white patients to receive the higher doses.

Those are the key findings of a study my colleagues and I conducted with 5,000 adults enrolled in Medicaid in Philadelphia who are prescribed buprenorphine to treat their opioid use disorder.

I am an assistant professor at University of Pennsylvania’s School of Nursing, and my research focuses on improving care and outcomes for people with opioid use disorder.

Why it matters

Buprenorphine is one of the most effective treatments for opioid use disorder. Unlike most opioids, buprenorphine only partially activates opioid receptors, providing enough stimulation to prevent withdrawal and cravings while not causing euphoria. This lowers the risk of overdose.

Buprenorphine also blocks other opioids from binding to opioid receptors and causing euphoric effects. This deters patients from using other opioids while on the medication.

Across the board, patients who received higher doses of buprenorphine – usually 17 to 24 milligrams per day, but sometimes more – stayed in treatment significantly longer than those who started on medium doses of 9 to 16 milligrams, or lower doses of 8 milligrams.

Staying in treatment for opioid use disorder is important because it reduces overdose risk and provides a foundation for recovery.

Our study also revealed racial disparities.

Black patients were less likely than white patients to receive the 17 to 24 milligram prescriptions. These differences may reflect prescriber preferences, inequities in health care or misconceptions among both patients and clinicians about safe dosing.

Other groups were more likely to receive higher buprenorphine doses. Over half of our sample was diagnosed with a musculoskeletal condition – such as osteoarthritis, rheumatoid arthritis and gout – alongside opioid use disorder. These patients were more likely to receive higher doses.

Why it matters

Over the past decade, the unregulated street opioid supply across the U.S. – and notably in Philadelphia – has become much more potent and unpredictable. The powerful synthetic opioid fentanyl as well as the animal tranquilizers xylazine and medetomidine are pervasive in Philadelphia. With these changes, standard buprenorphine doses may not be enough to stabilize withdrawal symptoms and prevent patients from using again.

Identifying disparities in buprenorphine dosing also sets up a number of interventions that insurers can use to address them.

For example, Community Behavioral Health, Philadelphia’s Medicaid behavioral health managed-care organization, has provided education about buprenorphine at faith‑based conferences, convened focus groups with Medicaid members to understand barriers to buprenorphine treatment, and allowed us to present our findings in a forum with local prescribers and pharmacists.

In December 2024, the U.S. Food and Drug Administration updated its recommendations about buprenorphine dosing. Previously, it supported a target dose of 16 milligrams and said that doses over 24 milligrams showed no clinical advantage.

Now, the FDA has removed the phrase “target dose” from the drug label. It also added that although doses over 24 milligrams have not been investigated in randomized clinical trials, they “may be appropriate for some patients.”

This clarification rolls back outdated language that many clinicians and insurers took to mean that 16 milligrams was the maximum for treating opioid use disorder.

What still isn’t known

Clinicians still do not fully understand patient preferences around buprenorphine dosing. Some patients may want higher doses to better manage withdrawal or cravings. Others may prefer lower doses due to concerns about not being able to discontinue buprenophrine if they are on a high dose.

The dosing patterns that we observed suggest that Black patients do not have equal access to higher doses of buprenorphine they may need. Understanding why these differences occur, and how to address them, is essential to equitable treatment.

The Research Brief is a short take on interesting academic work.

Read more of our stories about Philadelphia and Pennsylvania, or sign up for our Philadelphia newsletter on Substack.

Rachel French does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Higher buprenorphine doses help patients stay in opioid use disorder treatment, new study finds – https://theconversation.com/higher-buprenorphine-doses-help-patients-stay-in-opioid-use-disorder-treatment-new-study-finds-274804

Source: The Conversation – USA (3) – By Tim Hulsey, Associate Professor of Psychology, University of Tennessee

A few semesters into my teaching career as a psychology professor, I uncovered a cheating ring. I determined who the ringleader was and called him to my office.

He admitted that he had illicitly obtained a copy of the exam and shared it with other students. He began to cry, telling me he was from a single parent family, the first in his family to go to college, and that his mother would be crushed if he was dismissed from the university for academic dishonesty.

I did not know what to do. I was angry at what he had done, but I also felt sorry for his situation. For reasons I still don’t fully understand, I decided to call his mother. When I told her what he had done, she apologized repeatedly, then said coldly, “Let me speak to him.”

I don’t know what she said, but as the color drained from his face and he was reduced to repeatedly saying, “Yes, ma’am,” I assumed he was being read the riot act. After he hung up, he headed home to, I suspect, more severe punishment than the university could have given. He received a “0” on the exam and an official reprimand in his student file, but I’m willing to bet that the most important lesson he learned didn’t come from the university or me.

Though I didn’t yet know the word, the decision to call his mother was an example of phronesis, an ancient Greek word usually translated as “practical wisdom.” It refers to the ability to make good decisions in real-life situations, especially when there are no clear rules or easy answers.

Charioteer of the virtues, guiding them all

Phronesis provides you with the ability to deliberate well about what is good and bad in specific circumstances. Unlike theoretical knowledge (sophia) or technical skill (techne), phronesis is about judgment – how to choose the right action at the right time for the right reasons.

When you think about wisdom, maybe you imagine a philosopher pondering big questions or a scientist unlocking the secrets of the universe. But phronesis is a different kind of wisdom, one that is less about abstract ideas and more about navigating the messy, unpredictable realities of everyday life. Phronesis helps you live well, not by following rules, but by making wise choices in the face of complexity. It’s what allows you to turn knowledge into action that is then beneficial.

Phronesis is a central component of the virtue approach to character development and morality first described by Aristotle. Virtues like courage, generosity, justice and temperance tell you what goals you should aim for, but they don’t tell you how much, when or in what way you should act in a specific situation. Phronesis helps you think through and decide the right means to achieve the right ends in the moment.

Aristotle called phronesis “the charioteer of the virtues” because it provides the guidance system that ensures the other virtues are applied correctly in real life. As he put it, “It is impossible to be good in the strict sense without practical wisdom.”

Let’s take the example of courage. Everyone wants to be brave and stand up for their values. However, without phronesis, too much courage may become recklessness, or too little courage could result in cowardice. Phronesis allows you to know when to take a risk and when to hold back.

Or consider justice, the virtue of treating others fairly. Phronesis allows you to choose what is fair in a specific situation. Virtues set the goals – for instance, “be courageous” or “be just” – but phronesis determines the right way to achieve them.

Practice phronesis in the face of complexity

Developing phronesis takes time and effort. It requires experience, reflection and careful reasoning. Because phronesis is social, it thrives in environments where people share their perspectives and challenge each other’s assumptions.

You don’t have to be a philosopher or a scientist to practice phronesis. Modern life is full of complexity. We are regularly faced with questions that don’t have clear answers.

Picture a parent who must decide whether to enforce bedtime or allow a child to stay up for a special family occasion. The rule says bedtime is nonnegotiable, but practical wisdom reminds us of the value of shared family experiences.

Or consider a manager who notices an employee missing deadlines. Instead of simply reprimanding them, they might ask what’s going on and discover a family emergency. They could adjust expectations and offer support, balancing fairness with compassion.

These kinds of decisions reflect practical wisdom because they anticipate future needs, not just rules or consequences.

In a world obsessed with data and efficiency, phronesis reminds us that human judgment still matters. Algorithms can optimize processes, but they can’t weigh moral values or capture the subtleties of human relationships. Whether in education, health care, business or politics, decisions that affect lives require more than technical expertise. They require wisdom.

Phronesis counters the illusion that life’s problems have simple, one-size-fits-all solutions. It helps us realize that good judgment takes time, empathy and reflection. So, the next time you face a tough decision, pause and ask: What’s the wise thing to do?

Tim Hulsey does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Making good choices when life gets messy – practical wisdom relies on human judgment, not rules – https://theconversation.com/making-good-choices-when-life-gets-messy-practical-wisdom-relies-on-human-judgment-not-rules-271928

Source: The Conversation – USA (3) – By Danielle Wirsansky, Ph.D. Candidate in Modern European History, Florida State University

On the cold evening of Feb. 27, 1943, Charlotte Israel gathered with a small crowd of women on the Rosenstrasse, a narrow street in central Berlin. They were not Jewish, but their husbands were, and the men had just been arrested in a sweeping roundup of more than 9,000 Berlin Jews. Heinrich Himmler, leader of the SS and an architect of the Holocaust’s murder of 6 million Jews, called this arrest a “de-judaization of the Reich.”

Nearly 2,000 of those arrested had non-Jewish wives and were crammed together in a building on the Rosenstrasse. Israel and the other women who had gathered outside resolved to return the next day. Early the next morning, as she approached Rosenstrasse in search of her husband, Annie Radlauer heard a chorus of voices growing louder as she drew nearer: “Give us our husbands back!” The vigil, which sometimes grew into collective protests, continued off and on until March 6.

This protest still raises questions about how Hitler ruled and about attempts to rescue German Jews.

Families under pressure

Under the Nuremberg Laws of 1935, Nazi Germany banned marriage and sexual relations between Jews and people it considered “Aryans,” and it ratcheted up pressures for already married couples to divorce.

In most of these marriages, the non-Jewish partners were Christian women who faced enormous social stigma and political threats. Their households were considered “Jewish,” and the Gestapo could storm their homes, day or night, in a terrifying search.

Jewish women married to gentile men, on the other hand, lived under the protection of an “Aryan household,” and virtually all were exempted from wearing the yellow star that Jews in Germany were required to wear from 1941 onward. Yet their husbands were pressured by restrictions to their careers.

Jews married to Christians did face persecution, and at least hundreds of them were murdered in the Holocaust. The Gestapo deported Jews whose spouses had divorced them to labor and death camps, intending that they would never return.

Over the decade leading up to Rosenstrasse, however, as many spouses refused the pressure to divorce, the regime created temporary exemptions. Intermarried couples with Christian children were classified as “privileged” Jews, for example, exempt from wearing the yellow star. And until Himmler’s February 1943 campaign, even “non-privileged” Jews who did wear the star were “temporarily” held back from deportations.

Courage on the street

That February’s mass arrests are sometimes referred to as the “Factory Action,” since many Jews were arrested at work. But others were snatched from home or from the street if seen wearing the star.

The women and girls who gathered on Rosenstrasse were not political activists. They were wives, mothers and children trying to keep their families together under a murderous dictatorship. Their protest was unusual for its public visibility, since non-Nazi public gatherings were outlawed. Eyewitnesses recalled the women shouting for the release of their husbands and moments when guards threatened to shoot if protesters did not clear the street.

Most of the imprisoned Rosenstrasse Jews were released on March 6. American intelligence reported that Himmler’s action was discontinued “because of the protest which such action aroused.”

Meanwhile, 7,000 other Jews arrested in the same roundup – Jews not shielded by family relationships with non-Jews – were deported to Auschwitz, with many murdered.

Weighing the impact

Some scholars see the protest as tipping the balance to save the 2,000 men’s lives – based, in part, on events leading up to Rosenstrasse.

On Dec. 6, 1942, Adolf Hitler had authorized Joseph Goebbels, in his role as district leader of Berlin, to “ensure that the unprivileged full Jews are taken out of Germany,” likely to be murdered. And Nazi officials had promised Auschwitz’s Buna work camp thousands of skilled Jewish laborers – a quota that was not met because of the Rosenstrasse Jews’ release.

But Germany’s defeat in the Battle of Stalingrad by February 1943, coinciding with an increase in Allied bombing raids, sent public morale plunging. That made public opposition a bigger concern for the regime, especially for Goebbels, the propaganda minister. On March 6, he wrote that he had discontinued the deportation of the Rosenstrasse prisoners because “large throngs” gathered to side with the Jews.

During the decade since Hitler took power, women married to Jewish men defied scornful social, economic and political pressure, day after day. Some historians see their refusal to comply – even putting their lives on the line for their families – as causing Hitler to make a series of concessions.

Other scholars, however, say this runs “a danger of dramatically underestimating the power of the Nazi regime.” Gestapo terror suppressed all outward resistance, they argue, and a street protest could not have influenced policy.

This interpretation holds that the regime never intended to send the Rosenstrasse Jews to Auschwitz or elsewhere in the east but was holding the men to register them and select some for labor in Berlin.

Never before or after did the regime imprison Jews for such purposes. In any case, these protesters could only have had influence because they were not Jewish. Any Jewish resistance, such as the famous Warsaw Ghetto Uprising that started that April on the eve of Passover, was violently suppressed.

‘We stuck together’

Our research sees intermarriage and the Rosenstrasse protest as significant for several reasons.

First, they highlight how gender shapes expectations about protest and resistance. Nazi society cast women primarily as wives and mothers. Christian women wishing to reunite their families without calling for Hitler’s demise, or the release of all Jews, were harder for the regime to portray as political enemies or criminal agitators.

Second, the protest underscores the importance of visibility. Much of Nazi persecution relied on secrecy and masking genocide with bureaucratic language and routines. In Germany, deportations to killing sites or forced labor camps were often carried out quickly, with limited public exposure. A protest in the center of Berlin made secrecy impossible.

Third, the Rosenstrasse protest illuminates the range of responses available, in certain circumstances, to ordinary people living under Hitler. While armed resistance movements have received extensive attention, protests rooted in family and community operated differently. For example, Hitler compromised with German women who publicly protested orders to leave their families in order to evacuate cities being bombed by the Allies. Nazi officials appeased protesters opposing the removal of crucifixes from German schools.

The Rosenstrasse protest has become part of wider conversations about women-led resistance in World War II – alongside actions such as sheltering their Jewish neighbors, serving as couriers for underground networks or using workplaces and churches to quietly obstruct Nazi policies.

Decades later, Holocaust survivor Margot Graebert remembered what was at stake on Rosenstrasse. Her father and sister were held there, and her mother brought her to the protest. In the years before, “We’d seen so many families (of intermarriage) split up … and we stuck together.”

Rosenstrasse was not only a public protest but also a struggle to keep families from being torn apart: Above all, the women were fighting for the return of their own husbands and relatives. Its outcome does not change the scale of Nazi persecution or suggest that the regime tolerated dissent. But we argue that Rosenstrasse and its testimonies still matter today – not as a simple story of triumph but as a revealing debate about what protests could and could not accomplish under Nazism.

Danielle Wirsansky is affiliated with the Rosenstrasse Civil Courage Foundation.

Nathan Stoltzfus is co-founder of the Rosenstrasse Civil Courage Foundation.

– ref. Women of the Rosenstrasse protest challenged the Nazi regime for their detained Jewish husbands’ freedom – and won – https://theconversation.com/women-of-the-rosenstrasse-protest-challenged-the-nazi-regime-for-their-detained-jewish-husbands-freedom-and-won-277154