Cuando el transhumanismo se convierte en eugenesia: el caso de Jeffrey Epstein

Source: The Conversation – (in Spanish) – By Leandro Gaitán Mántaras, Doctor en Filosofía, Universidad de Navarra

La investigación científica en la mejora de la raza humana puede conllevar grandes dilemas éticos. Bhautik Patel / Unsplash., CC BY

El pasado 30 de enero de 2026, el Departamento de Justicia de EE. UU. autorizó la publicación de un archivo masivo: 3,5 millones de páginas, 180 000 fotos y 2 000 vídeos que, según la ONU (2026), “contienen evidencia inquietante y creíble de tráfico y esclavitud sexual de mujeres y niñas a gran escala, tortura, desaparición forzada, tratos inhumanos y degradantes, y asesinato”.

Estos delitos, añade el organismo, se cometieron en un contexto de supremacismo, misoginia extrema, mercantilización y deshumanización sistemática. Los archivos mencionan a figuras de alto perfil de la élite occidental –políticos, empresarios, científicos, celebridades– y sugieren la existencia de una red de complicidades que acentúa el carácter estructural y la gravedad institucional de los hechos.

Fascinado por el transhumanismo

Sin embargo, más allá de los titulares escandalosos, emerge un componente ideológico menos explorado pero decisivo: el profundo compromiso de Epstein con el pensamiento transhumanista y la investigación científica orientada a la “mejora humana” (human enhancement).

Foto policial de Jeffrey Epstein (2006).
Foto policial de Jeffrey Epstein (2006).
Wikimedia Commons, CC BY

Este escenario nos sitúa ante un interrogante ineludible: ¿puede una determinada forma de entender al ser humano contribuir a erosionar o eliminar los límites morales que lo protegen? Más concretamente, ¿hasta qué punto la cosmovisión transhumanista de Epstein pudo haber funcionado como marco legitimador de su conducta?

Según un artículo del New York Times publicado en 2019, Epstein mostró durante años una recurrente fascinación por el transhumanismo, entendido como el intento de mejorar la especie humana “mediante tecnologías como la ingeniería genética o la inteligencia artificial”. No se trataba de una curiosidad superficial: invirtió millones de dólares en investigación sobre la dinámica evolutiva, la cognición como computación, el moldeamiento de la conducta, las tecnologías de rejuvenecimiento y superlongevidad, y las interfaces hombre-máquina.

Entre 1998 y 2008, el magnate pederasta donó más de 9 millones de dólares a la Universidad de Harvard, incluyendo financiación clave para el Programa de Dinámica Evolutiva, según explica un informe reciente publicado en Nature. También donó, entre 2002 y 2017, más de 7,5 millones de dólares al MIT Media Lab –que investiga en muchas áreas muy distintas, una de ellas, cómo alargar la vida humana– y apoyó a organizaciones como Humanity+ (antes Asociación Transhumanista Mundial) y a investigadores vinculados al movimiento transhumanista.

A diferencia de la filantropía orientada a la búsqueda de estatus, reconocimiento social o expansión del prestigio personal, Epstein hacía sus donaciones muy discretamente y, en ocasiones, de manera completamente anónima.

Sus contribuciones, lejos de dispersarse, se concentraban en áreas científicas convergentes y con un perfil inequívocamente transhumanista. A esta estrategia de financiación se suman algunos proyectos personales que permiten vislumbrar con mayor claridad su visión del ser humano.

Una raza humana superior

En efecto, Epstein expresó su intención de utilizar su rancho de Nuevo México (una mansión de 3 000 hectáreas) como base para experimentos genéticos, incluyendo un plan para inseminar simultáneamente a veinte mujeres y “sembrar la raza humana” con su ADN. Se creía poseedor de una genética privilegiada y superior, según revelaba el citado artículo del New York Times.

También se interesó por la creación de un repositorio de material genético (Repository for Germinal Choice) de premios Nobel y por la criónica (congelación de cuerpos o cerebros humanos a temperaturas extremadamente bajas inmediatamente después de la muerte legal, con la esperanza de que la tecnología futura pueda reanimarlos), como modo de recuperar y prolongar la vida tras la muerte.

Asimismo, según relata el psicólogo Steven Pinker, Epstein criticó los esfuerzos por combatir el hambre y mejorar la asistencia sanitaria a los pobres argumentando que ello incrementaba el riesgo de superpoblación. Esa visión delata una transición peligrosa hacia la subordinación de la vida humana a criterios de eficiencia técnico-instrumental.

El ser humano como objeto

La cuestión no es, por supuesto, que el transhumanismo conduzca necesariamente a comportamientos criminales. Se trata de una corriente heterogénea con propuestas que van desde posiciones moderadas hasta planteamientos muy radicalizados. Sin embargo, en sus versiones más extremas, introduce la idea potencialmente problemática de que el ser humano, entendido como objeto de mejora, es susceptible de ser diseñado, modificado y, por tanto, manipulado.

Cuando esta lógica es llevada hasta sus últimas consecuencias, el riesgo no es solo técnico, sino antropológico y ético. El mejoramiento biotecnológico puede acabar funcionando como un criterio dominante que condiciona la manera de percibir y tratar a los demás.

Desde esta óptica, el otro ya no es considerado como un fin en sí mismo –dotado de una dignidad que le es inherente–, sino como herramienta u objeto técnico-artificial maleable y, eventualmente, descartable.

Este tipo de racionalidad centrada en el cálculo, la eficiencia y el control, fue analizada críticamente por pensadores como Aldous Huxley, Max Horkheimer, Theodor W. Adorno, y Herbert Marcuse. Dichos autores sostienen que, cuando ese modelo de racionalidad instrumental o técnica se absolutiza, puede terminar legitimando la subordinación de unas personas a los intereses de otras y desembocar en una ideología tecnocrática y totalitaria que no mira costos humanos.

Peligros de la eugenesia

Con todo, situar los hechos en este contexto ideológico no excluye la necesidad de cautela. Resulta fundamental no incurrir en reduccionismos, pues un caso como el de Epstein difícilmente puede explicarse mediante una sola causa. Factores de orden político, psicológico, social o biográfico pudieron haber desempeñado un papel decisivo en la configuración de su conducta.

Sin embargo, reconocer esta complejidad no impide señalar que determinados marcos de pensamiento pueden contribuir a imaginar –e, incluso, justificar– ciertas prácticas. Las denuncias contra Epstein y sus adláteres no describen únicamente delitos aislados de carácter sexual, sino la existencia de una estructura organizada en la que mujeres y niñas eran tratadas como recursos intercambiables, sometidas a una lógica de uso, selección y descarte.

Sin establecer una relación causal directa, la inquietante convergencia entre esta praxis y una concepción del ser humano como objeto de “mejora” invita, al menos, a una reflexión crítica.

El fenómeno Epstein deja, en este sentido, una advertencia: cuando la racionalidad instrumental se impone como criterio dominante para determinar el valor y el destino de las personas, se abre paso a su cosificación y, en consecuencia, a la legitimación de prácticas que atentan contra su dignidad.

The Conversation

Leandro Gaitán Mántaras no recibe salario, ni ejerce labores de consultoría, ni posee acciones, ni recibe financiación de ninguna compañía u organización que pueda obtener beneficio de este artículo, y ha declarado carecer de vínculos relevantes más allá del cargo académico citado.

ref. Cuando el transhumanismo se convierte en eugenesia: el caso de Jeffrey Epstein – https://theconversation.com/cuando-el-transhumanismo-se-convierte-en-eugenesia-el-caso-de-jeffrey-epstein-281035

Por qué sí tiene sentido enseñar Geografía e Historia en inglés

Source: The Conversation – (in Spanish) – By Esther Nieto Moreno de Diezmas, Catedrática y Directora del Departamento de Filología Moderna, Universidad de Castilla-La Mancha

En las últimas décadas, la enseñanza bilingüe se ha expandido con rapidez y ha alcanzado un notable reconocimiento internacional. En España, el modelo está ampliamente implantado: el 41,4 % del alumnado de primaria y el 32,2 % de secundaria participa en programas bilingües cursando materias como Ciencias Sociales, Matemáticas, Educación Plástica, Historia o Física y Química en lengua extranjera.

Este crecimiento ha sido impulsado por las políticas de la Unión Europea que buscan aumentar la exposición a lenguas extranjeras, fomentar el plurilingüismo y favorecer la movilidad, la empleabilidad y la inclusión en todo el territorio europeo.

El caso de Historia

No obstante, su rápida expansión también ha generado debate, especialmente en el ámbito de las Ciencias Sociales. Muchos pueden preguntarse si tiene sentido hablar de The Catholic Monarchs en contextos de habla hispana.

En esta línea, en la Comunidad de Madrid, desde el curso 2024-2025, parte de las asignaturas de Ciencias Sociales y Geografía e Historia ha dejado de impartirse en lengua extranjera en primaria y en secundaria, para enseñarse obligatoriamente en español.

Este cambio plantea un debate interesante: ¿Resulta pedagógicamente beneficioso o limitador impartir contenidos históricos –en especial de la historia del propio país– en una lengua extranjera?

¿Por qué Historia en inglés?

Frente a otras asignaturas, la elección de las Ciencias Sociales para ser impartidas en una lengua extranjera es ideal para el aprendizaje del idioma. En esta materia, el lenguaje es una herramienta central del aprendizaje y se maneja una gran cantidad de vocabulario, expresiones y formas gramaticales.

El alumnado aprende a describir, definir, explicar, evaluar, comparar, justificar y narrar, con lo que hace uso de las funciones cognitivas del discurso. Es así como se contribuye a desarrollar el pensamiento crítico y el lenguaje académico.

Además, a través de estas materias se fomenta un aprendizaje real, significativo y natural del idioma y se promueve la competencia intercultural. Por ello, en la mayoría de los programas bilingües europeos, Ciencias Sociales y Geografía e Historia son las materias más habitualmente impartidas en una segunda lengua.




Leer más:
Las ventajas de la educación bilingüe, según los estudiantes


Adquisición de los contenidos

La mayoría de las investigaciones indican que la enseñanza bilingüe no perjudica el aprendizaje de las Ciencias Sociales. Por ejemplo, estudios publicados en Finlandia, Chipre y Holanda muestran resultados similares o superiores del alumnado bilingüe.

En España, varias investigaciones identifican rendimientos equivalentes o mejores del alumnado en programas bilingües. Aunque algunos estudios detectan desventajas puntuales para alumnado bilingüe de primaria, investigaciones con muestras muy amplias y controladas concluyen que no existen diferencias significativas y que, al finalizar la secundaria, el alumnado bilingüe puede incluso superar al no bilingüe.




Leer más:
Cómo enseñar ciencias o historia en inglés de manera eficaz


Estudios longitudinales también detectan progresos más rápidos en Ciencias en programas bilingües. En definitiva, la evidencia sugiere que la educación bilingüe garantiza la adquisición de contenidos con niveles de rendimiento iguales o superiores a los de la enseñanza ordinaria.

Beneficios cognitivos y competencias globales

La enseñanza bilingüe se basa en el Aprendizaje Integrado de Contenidos y Lenguas extranjeras (AICLE/ CLIL). El aprendizaje integrado genera ventajas cognitivas en el alumnado bilingüe. Esto es así debido al doble esfuerzo que se requiere para procesar información en otra lengua, algo que activa y ejercita el cerebro, como muestran diversos estudios.

Así pues, el alumnado bilingüe utiliza más estrategias de aprendizaje, mejora su capacidad para procesar información y muestra niveles superiores en pensamiento crítico y en la competencia de aprender a aprender.

Además, estudiar Ciencias Sociales y Geografía e Historia en otra lengua, permite acceder a fuentes internacionales, mapas, datos comparados y perspectivas históricas diversas. De este modo, promueve la competencia global.




Leer más:
Más allá del vocabulario y la gramática: aprender biología o historia en inglés


Guías pedagógicas y de mejora

En cualquier caso, los programas bilingües están en continua evolución y es preciso seguir velando por su calidad. Resulta imprescindible invertir en una formación docente especializada, tanto inicial (en la universidad) como permanente. Es fundamental garantizar la mejora del nivel lingüístico del profesorado, y el dominio de las estrategias pedagógicas y los principios metodológicos del AICLE.

También es necesario contar con un diseño institucional adecuado del programa. El porcentaje de horas de exposición curricular a la lengua extranjera, la provisión docente y la exigencia en el acceso de niveles lingüísticos y de capacitación metodológica del profesorado son factores clave. Proporcionar guías pedagógicas claras, dotar con los recursos necesarios, así como inspeccionar y evaluar estos programas periódicamente es fundamental. Solo así podrá asegurarse que la enseñanza bilingüe cumpla su potencial educativo y equitativo.

The Conversation

Esther Nieto Moreno de Diezmas recibe fondos de la Universidad de Castilla-La Mancha y ha participado en proyectos de investigación financiados por el Ministerio (MICIN)

ref. Por qué sí tiene sentido enseñar Geografía e Historia en inglés – https://theconversation.com/por-que-si-tiene-sentido-ensenar-geografia-e-historia-en-ingles-276460

Los músculos ‘hablan’ con todo el cuerpo: la revolución científica que cambia la visión del ejercicio

Source: The Conversation – (in Spanish) – By Beatriz Carpallo Porcar, Fisioterapeuta. Personal docente e investigador en el grado de Fisioterapia en la Universidad San Jorge. Miembro del grupo de investigación iPhysio., Universidad San Jorge

La idea de que el músculo es un simple motor mecánico ha quedado obsoleta gracias a un hallazgo que ha cambiado la fisiología moderna: en realidad, funciona como un órgano endocrino capaz de influir en prácticamente todos los sistemas de nuestro cuerpo.

Durante la contracción muscular se liberan cientos de moléculas llamadas mioquinas, sustancias imprescindibles para que el organismo funcione de forma correcta. De ahí nació la idea de que “el ejercicio es medicina”. Sin embargo, este concepto también ha pasado de moda. En realidad, habría que ir más allá y decir que es tan necesario para nuestra salud como respirar o comer, mientras que el sedentarismo y la falta de movimiento constituyen una fuente de enfermedad.

Qué son las mioquinas

Las mioquinas actúan como hormonas que se comunican a través del torrente sanguíneo con distintos órganos como el cerebro, el tejido adiposo, el hígado, el hueso o el sistema inmune. Según una revisión de 2024, son la razón por la que el ejercicio sea beneficioso para el sistema inmunitario.

La mioquina más estudiada hasta el momento es la interleucina‑6 (IL‑6), que se libera durante ejercicios de alta intensidad o de resistencia aeróbica hasta 100 veces más que en reposo. También tienen importancia la irisina, clave para mantener el equilibrio de la grasa corporal, y el factor neurotrófico derivado del cerebro (BDNF), implicado en la neuroplasticidad y la función cognitiva.




Leer más:
Cuando hacemos ejercicio, nuestros músculos ‘hablan’ con el cerebro y lo fortalecen


Y antes de centrarnos en los efectos de esta familia de moléculas, hay que tener en cuenta que el movimiento también estimula que otros órganos liberen las no menos importantes exerquinas. Por ejemplo, una revisión de 2022 revela su participación en la mejora cardiovascular, metabólica, inmune y neurológica. Si nos movemos poco y circulan pocas exerquinas por nuestro organismo, aumenta el riesgo de enfermedad y mortalidad por todas las causas.

Torrente de moléculas benefactoras

A continuación desglosamos cómo actúan las mioquinas en distintas partes de nuestro organismo:

  • Sistema inmune. Publicaciones recientes identifican al menos nueve mioquinas que influyen en el funcionamiento adecuado del sistema inmune. Entre ellas destacan la irisina, la decorina y las interleucinas IL-6, IL-7 o IL-15. Su liberación durante el ejercicio favorece la proliferación y diferenciación de las células de nuestras defensas, lo que potencia la “vigilancia inmunitaria”.

    Además, reducen la inflamación sistémica crónica, factor clave en la prevención de muchas enfermedades metabólicas y cardiovasculares. La IL‑6, por ejemplo, actúa como una señal antiinflamatoria capaz de modular la actividad de los linfocitos, los macrófagos y las células NK.

  • Sistema nervioso y neurocognitivo. El músculo ejerce una influencia directa sobre el cerebro a través de lo que se ha llamado “eje músculo‑cerebro”. La evidencia muestra que moléculas como BDNF, la irisina o la cathepsina B pueden estimular la formación de nuevas neuronas. También tienen efecto en la mejora del aprendizaje y la memoria y se asocian con la protección frente al deterioro cognitivo de enfermedades neurodegenerativas.

    Por ejemplo, la irisina se ha vinculado con un incremento de BDNF en el hipocampo, una región crucial para la memoria. A su vez, la cathepsina B contribuye a procesos de regeneración neuronal y mejora de la cognición.

    Este conjunto de señales químicas explica por qué las personas activas muestran menor riesgo de deterioro cognitivo y mejor salud emocional: el cerebro “escucha” lo que los músculos dicen cuando se contraen, y responde adaptándose y fortaleciéndose.

  • Metabolismo de la glucosa y las grasas. Durante el ejercicio, la IL‑6 desempeña un papel esencial al movilizar ácidos grasos desde el tejido adiposo, principalmente del visceral (el que se acumula en la cavidad abdominal y presenta mayor riesgo). Así favorece la quema de las grasas y contribuye al mantenimiento de los niveles de glucosa en sangre.

    También modula la sensibilidad a la insulina, facilitando que el músculo capte glucosa de manera más eficiente. Este mecanismo explica parte de los beneficios del ejercicio en la prevención de la diabetes tipo 2. En conjunto, el músculo actúa como un “termostato metabólico” que ajusta el gasto energético y establece cuándo movilizar, almacenar o utilizar energía en función de la actividad física.

  • Sistema cardiovascular. Aunque el ejercicio en pacientes cardíacos debe ser prescrito por un profesional sanitario como el cardiólogo o el fisioterapeuta, puede ser muy beneficioso para prevenir enfermedades cardiovasculares. La actividad física induce la liberación de exerquinas que favorecen la vasodilatación, mejoran la función vascular y reducen la rigidez arterial. Esto explica por qué las personas físicamente activas presentan menor riesgo de hipertensión, enfermedades coronarias y fallos cardíacos.

  • Huesos y osteoporosis. El músculo dialoga también con nuestro esqueleto. Varias mioquinas favorecen la formación y remodelación de los huesos, estimulando la actividad de los osteoblastos (células constructoras de hueso) y modulando la densidad mineral ósea. Es un complemento necesario a las cargas mecánicas del ejercicio para prevenir y combatir la osteoporosis.

  • Control tumoral y reducción del riesgo de cáncer. Un artículo publicado en The Lancet Oncology relaciona el sedentarismo como factor de riesgo en más de 10 tipos de cáncer. En parte se explica porque durante el ejercicio se liberan mioquinas que inhiben la proliferación de células cancerosas y reducen el daño en el ADN de las células potencialmente malignas.

    A esto se suma su capacidad de movilizar células del sistema inmune capaces de reconocer y destruir células tumorales en fases tempranas. Una sola sesión de ejercicio aumenta significativamente los niveles de mioquinas con potencial de suprimir el crecimiento de células cancerosas.

En conjunto, toda esta evidencia demuestra que el músculo funciona como un verdadero centro endocrino: cada contracción muscular envía señales que ajustan el equilibrio interno del organismo, lo que confirma que moverse es una necesidad biológica para que nuestros sistemas del cuerpo funcionen correctamente.

The Conversation

Las personas firmantes no son asalariadas, ni consultoras, ni poseen acciones, ni reciben financiación de ninguna compañía u organización que pueda obtener beneficio de este artículo, y han declarado carecer de vínculos relevantes más allá del cargo académico citado anteriormente.

ref. Los músculos ‘hablan’ con todo el cuerpo: la revolución científica que cambia la visión del ejercicio – https://theconversation.com/los-musculos-hablan-con-todo-el-cuerpo-la-revolucion-cientifica-que-cambia-la-vision-del-ejercicio-277572

Global supply chains cause environmental harm, but they can help repair it too

Source: The Conversation – Canada – By Minelle Silva, Professor in Supply Chain Sustainability, University of Manitoba

The COVID-19 pandemic drew attention to how central supply chains are to the global economy. It also exposed the human rights abuses that can occur up and down supply chains before goods arrive in our hands.

By contrast, the environmental impacts of supply chains and the disproportionate burdens they place on the world’s most vulnerable people have been overshadowed in public debate.

Some observers assert these impacts rise to the level of environmental injustice – situations in which supply chains actively harm people, communities and the environment. They argue that the companies managing supply chains should be held responsible for reversing these effects.

When supply chains move beyond traditional markers of performance — efficiency, flexibility and responsiveness — to consider the benefits and harms of their activities, they can become environmentally just. Such supply chains distribute environmental benefits (such as clean air, water or access to land) more fairly while ensuring all stakeholders are included in decision-making.

In our recent research study, my colleagues and I argue that environmental justice should be treated as a core concept of sustainable supply chain management. We identify three pathways that offer practical entry points for businesses and other organizations seeking to address environmental injustice within supply chains.

Expanding due diligence

The first pathway involves incorporating environmental justice into human rights due diligence, the process businesses use to identify and address harms. Due diligence includes identifying and assessing potential harms, taking action, monitoring outcomes and being transparent about how harms are addressed.

While some businesses typically focus on their human rights impacts, they can go further. Environmental justice is closely linked to violence against environmental rights defenders, such as Indigenous land defenders or community activists, who face disproportionate environmental harms and risks and organize to resist them.

Businesses should therefore make public commitments to respect environmental rights defenders, disclose how they assess and act on those commitments, and implement mechanisms for redress if violations occur.

At the global level, the United Nations Environment Programme has recently developed guidelines for conducting human rights due diligence with an environmental perspective to aid businesses in these efforts.

In Europe, the European Union’s Corporate Sustainability Due Diligence Directive now requires companies to conduct human rights and environmental due diligence across their operations and supply chains. While due diligence has been seen as a way to target international human rights, its effectiveness still relies on how well it’s implemented across different types of supply chains.

Some companies have begun to move in this direction. Coca-Cola, for example, has adopted a zero-tolerance policy on traditional and Indigenous land grabs — a major driver of environmental injustice — within their supply chains, with third-party monitoring.

Similarly, Shell, Kellogg’s and Rio Tinto have all incorporated respect for environmental rights defenders in their human rights policies. Canadian firms, too, have faced growing pressure to adopt similar approaches, though such measures are not yet mandatory.

Building resilient supply chains

The second approach is to incorporate resilience thinking into supply chain strategies to restore and regenerate the communities and environments damaged by supply chain activities.

Resilience thinking suggests that small-scale changes can lead to larger-scale transformations. This perspective is particularly important in the context of climate change.

Greenhouse gas emissions generated along supply chains can remain in the atmosphere for hundreds, if not thousands, of years. Simply reducing emissions is not enough. To achieve climate justice, carbon dioxide must be removed from the atmosphere.

Resilience-focused supply chains can contribute by integrating technologies that remove carbon dioxide from the atmosphere into their operations, such as capturing carbon and storing it within soil or carbonate minerals like limestone in oceans.

Firms in industrialized nations, which are responsible for a disproportionate share of emissions, should be the first to implement these strategies in their supply chains and to finance their adoption in poorer countries.

Such measures can help reduce environmental harms, more equitably distribute environmental benefits and increase the resilience of people and the environments they depend on.

Working with affected communities

The third pathway is to work directly with stakeholders to build fairer supply chains. Environmental harm is rarely caused by just one step in a supply chain, so fixing it requires people working together.

Collaborative initiatives can help by bringing together businesses (sometimes competitors), community representatives, policymakers and civil society organizations.

These collaborations pool resources to tackle issues like human rights abuses, deforestation, climate change and biodiversity loss. However, they are only effective if they place community and environmental concerns ahead of short-term business interests and embrace diverse forms of knowledge, as some mining companies in Australia have begun to do.

It’s only when the communities affected by environmental injustice participate in redress that environmentally just supply chains can have lasting, positive effects.

From sustainability to justice

Business responses to the environmental crisis will remain limited until environmental justice is fully incorporated into supply chain sustainability strategies.

Without this shift, efforts to improve sustainability risk overlooking how environmental harms and benefits are unevenly distributed across communities.

To meaningfully transform supply chains into mechanisms of lasting environmental justice, managers must adopt these three pathways.

When those responsible for the greatest harms to the world’s most vulnerable communities take meaningful action to address them, then they can start to reshape communities, businesses and the world for the better.

Marina Dantas de Figueiredo, academic co-ordinator at CESAR School, co-authored this article.

The Conversation

The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

ref. Global supply chains cause environmental harm, but they can help repair it too – https://theconversation.com/global-supply-chains-cause-environmental-harm-but-they-can-help-repair-it-too-278157

Does menopause cause a ‘collagen cliff’? What you need to know

Source: The Conversation – UK – By Adam Taylor, Professor of Anatomy, Lancaster University

Fibroblast, collagen and elastin fibres. Olga Zinkevych/Shutterstock

Collagen has become a staple of skincare advertising and social media wellness trends. But it is not just a buzzword.

It is the most abundant protein in the body and helps support structures throughout the body, including skin and bone.

For women, collagen loss can become especially noticeable during perimenopause and menopause. Some studies suggest that skin collagen may fall by as much as 30% in the first five years after menopause, with further losses of around 2% a year after that. On social media, this is sometimes called the “collagen cliff”, but the underlying idea is not new. Researchers have been writing about the effects of menopause on skin for decades, with papers from at least the 1940s pointing to the connection.

This sharper drop happens on top of the gradual changes that come with ageing. Collagen appears to decline over time, with some estimates suggesting a fall of around 1–1.5% a year from early adulthood.

Oestrogen helps regulate many processes in the body, including the production of collagen. In animal studies, oestrogen has been shown to increase collagen production and skin thickness. Human research has also found benefits for skin thickness, elasticity and wound healing.

This is partly because oestrogen acts on fibroblasts, the cells responsible for making collagen in the skin. When oestrogen levels fall during perimenopause and menopause, this signalling becomes weaker. The result is less collagen being produced, along with thinner skin, reduced elasticity and lower water content.

Collagen loss cannot be stopped entirely, but some factors can speed it up. One of the most important is ultraviolet radiation from the sun and tanning beds. This increases enzymes called matrix metalloproteinases, which act like the skin’s demolition crew, breaking down structural proteins such as collagen. These enzymes are found at higher levels in skin that has been damaged by the sun.

Ultraviolet radiation reduces the amount of new collagen that fibroblasts produce. People with darker skin tones tend to show less wrinkling, probably in part because higher melanin levels offer some protection against ultraviolet damage. But darker skin is not immune to photo-ageing, which means skin ageing caused by sun exposure.

Smoking appears to accelerate collagen loss. One study found that smoking reduced skin production of type I and type III collagen by 18% and 22% respectively, contributing to premature ageing of the skin.

Vitamin C is essential for collagen production. Around 100mg per day is enough for most adults, although smokers may need more. Many wellness supplements provide much larger doses, often around 1,000mg a day, but more is not necessarily better; around 2,000mg a day causes unpleasant gastrointestinal issues.

Products that claim to boost collagen are increasingly popular, but the evidence behind them is mixed. Topical collagen creams are unlikely to replace collagen lost from the skin because intact collagen molecules are too large to get through the skin barrier. They may help moisturise the outer layers of the skin, but they are unlikely to make a major difference to the skin’s own collagen levels.

Oral collagen supplements have been linked in some studies to improvements in skin hydration and elasticity. However, the scientific literature remains mixed. Reviews point to limitations in the evidence, including small study sizes, potential conflicts of interest and inconsistent findings, leading researchers to urge caution when interpreting the results. In the same way that collagen can’t be absorbed through the skin, the body has to digest it to absorb the amino acids that make collagen and there is no way to ensure the amino acids that made that collagen go to the skin or wherever you hoped it would. Hydrolysed collagen is better for absorption but there is still no guarantee that the body uses it where you want it to.

Hormone replacement therapy may offer more consistent benefits. As well as helping with other symptoms of menopause, HRT has been shown in some studies to improve skin thickness, elasticity and hydration. One study reported that women receiving HRT had a 48% increase in skin collagen content compared with untreated women, and other studies have reported similar trends. Some evidence suggests that transdermal (through-the-skin) oestrogen may also have measurable effects on skin collagen. But the overall risks and benefits of HRT always need to be considered on an individual basis.

Some dermatologists and cosmetic practitioners also use procedures designed to stimulate collagen production. Laser resurfacing treatments aim to trigger repair processes in the skin and remove damaged collagen. Newer versions of these treatments are designed to reduce side effects.

Microneedling is another commonly suggested option, although it is not risk free. Potential complications include pain, bruising, bleeding, infection, changes in skin colour, and in rare cases abnormal growths. It can also cause hyperpigmentation, which means patches of skin become darker than the surrounding area.

By the time menopause begins, collagen has usually already been declining for years. Protecting the skin from ultraviolet damage, avoiding smoking and getting enough vitamin C may help support the body’s natural collagen levels.

Menopause may speed up collagen loss, but the picture is more complex than social media slogans suggest. While collagen supplements remain popular, the science behind them is still developing. HRT has a clearer scientific basis for improving skin thickness, elasticity and hydration in some women, although it is not suitable for everyone. When it comes to collagen, the science is more helpful than the hype.

The Conversation

Adam Taylor does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Does menopause cause a ‘collagen cliff’? What you need to know – https://theconversation.com/does-menopause-cause-a-collagen-cliff-what-you-need-to-know-278127

A new Welsh electoral landscape puts Plaid Cymru within reach of power

Source: The Conversation – UK – By Anwen Elias, Reader in Politics, Aberystwyth University

Plaid Cymru’s electoral hopes for May’s Senedd election are high. Polls suggest the party is competing with Reform UK to emerge as the largest group in the next Welsh parliament, putting it, for the first time, within reach of leading a government in Wales.

This marks a striking shift in Plaid’s electoral fortunes. At the first election to what was then the National Assembly for Wales in 1999, the party won 28.4% of the vote. That remains its strongest performance to date in what was widely described at the time as a “quiet earthquake” in Welsh politics.

Since then, Plaid has struggled to match that breakthrough in devolved elections. From 2011 onwards it has consistently been the third-largest party in the Senedd, behind Welsh Labour – which has led every government since devolution – and the Conservatives.

Even so, the arithmetic of Welsh politics has occasionally worked in Plaid’s favour. The party entered government in coalition with Labour between 2007 and 2011, and more recently struck a co-operation agreement from 2021 to 2024. But if Plaid ends up leading a government outright after May 7, it would truly set this election apart.

Positioning itself for power

Plaid Cymru’s strategy is to present itself as a credible government-in-waiting. Its focus is less about being a party of protest and more about delivery. In other words, what it would do in office, how it would tackle Wales’s major policy challenges, and how it would represent Welsh interests at Westminster after nearly three decades of Labour dominance.

In February, the party set out its plan for its first 100 days in government. This focused on improving healthcare, raising education standards, boosting the economy and reforming government.

Alongside these priorities, its manifesto calls for further powers to be devolved to the Senedd. These include greater tax powers, justice and policing, rail services and infrastructure, and the Crown Estate, which oversees things like the sea bed and mineral rights in much of the countryside.




Read more:
Plaid Cymru plans to share wind farm profits with local people – here’s how that idea has been tried elsewhere


Yet there has also been a noticeable change in tone on the party’s long-term constitutional aims. Our research examined how Plaid Cymru covered these issues in the 2021 Senedd election. Compared with five years ago, Welsh independence is significantly less prominent in both its current manifesto and campaign.

The timetable has softened too. There’s no longer a commitment to holding a referendum on independence in its first term of government. Instead, Plaid describes Wales as being “on a journey” to independence. It has committed to producing a policy on Welsh independence but with no referendum timeframe.

By downplaying its long-term constitutional ambitions in this way, and focusing on the more immediate policy challenges facing Wales, Plaid Cymru is approaching this Senedd election as many other pro-independence parties have done across Europe. A similar strategy helped the Scottish National Party win power in 2007 and remain in government for the next 19 years.

A ‘degradation in belief that Labour stood for Wales,’ says Plaid Cymru leader – Sky News.

From polling strength to political power

Strong polling does not guarantee power, however, and Plaid faces several obstacles. Opponents continue to highlight its commitment to independence.

Support for independence among the Welsh public remains relatively low – only 26% of respondents in a recent YouGov poll agreed that Wales should be an independent country. Plaid’s challenge is to persuade sceptical voters that this isn’t the most important issue in Wales for the next four years.




Read more:
Voters in Wales face Senedd election amid confusion over who holds power over what


The new electoral system also presents fresh uncertainties. This election will use a fully proportional model, with 96 members elected across 16 constituencies. Success will now depend on broad support across Wales. That’s a test for a party whose organisational strength has traditionally been concentrated in the north and west.

The new system is also likely to produce a more fragmented Senedd, with a wider range of parties represented. That could make post-election negotiations decisive, shaping who is able to lead a government and how stable it is.

The Conversation

Anwen Elias receives funding from the Economic and Social Research Council.

Elin Royles has received funding from the Economic and Social Research Council and the broader research underpinning this publication formed part of an EU Horizon2020 project

ref. A new Welsh electoral landscape puts Plaid Cymru within reach of power – https://theconversation.com/a-new-welsh-electoral-landscape-puts-plaid-cymru-within-reach-of-power-279628

Romeo and Juliet: a ‘Sliding Doors’ production that plays with time to explore what might have been

Source: The Conversation – UK – By Will Shüler, Vice-Dean of Education and Senior Lecturer, School of Performing and Digital Arts, Royal Holloway, University of London

Structurally, Romeo and Juliet is almost a Shakespearean comedy. The Bard’s comic plays tend to turn the world upside down and then neatly restore the social order, usually by means of marriage.

The world of Romeo and Juliet is turned upside down when two adolescents from warring families fall in love, and the world is set right when the families are united in marriage. But then there are three more acts and the plot veers towards tragedy, tallying six deaths by its end.

Robert Icke’s new production of Romeo and Juliet at the Harold Pinter Theatre thoughtfully interrogates the play’s structure by introducing moments of might-have-been throughout. Starring Noah Jupe (Hamnet) and Sadie Sink (Stranger Things) in the respective titular roles, Icke offers glimpses of how the story might have unfolded differently, in a kind of Sliding Doors version of the play.

Early in the production, Lord Capulet (Clark Gregg) gives the invitation list for his party to the Nurse (Clare Perkins). Then time freezes, we move backwards, and Capulet hands the note instead to an illiterate servant, who bumps into Romeo on the street and asks for his help reading it. Romeo learns of the party and decides to attend in order to see his current crush, Rosaline. Had the Nurse been given the task, she would never have needed help reading the list and Romeo would never have met Juliet.

In this way, the production is riddled with tiny moments that could have altered the plot’s trajectory away from tragedy. In doing so, we get to see alternate universes that make up a multiverse. The multiverse has been a regular device in recent popular storytelling, from the Marvel Cinematic Universe to the adult cartoon Rick and Morty.

Plays like Nick Payne’s Constellations, which had a West End revival in 2021, stage a multiverse by showing how the same scene between two characters might have happened in several different ways, across an infinite number of timelines.

I have written about theatrical multiverses, demonstrating that they offer the audience space to reflect upon how things might have gone differently in their own worlds. In 2021, just after the third UK Covid lockdown, the audience of Constellations was likely attuned to contemplating a world in which they did not expect to find themselves.

With the tumultuous state of the world, it can sometimes feel like we are living in the wrong timeline. The popularity of multiverse stories may seen as ways of reconciling living in our own world, that often feels as if it has been turned upside down.

Romeo and Juliet’s multiverse

As Daniel Swift’s programme note attests, Romeo and Juliet is very much about time. The plot is compressed into five days and it includes more references to days of the week, hours and minutes than any of Shakespeare’s other works. This preoccupation with time is emphasised by Hildegard Bechtler’s set design, which includes two moving panels with illuminated clocks, presenting the precise time and date in fair Verona.

Along with helping the audience understand when we see alternate timelines, the constant reminder of time allows us to reflect on just how quickly things escalate for Romeo and Juliet.

The lovers marry within hours of meeting each other and Romeo is already banished in Mantua before they’ve been wedded for a full day. In this way, the clock points to the youthful haste which creates so much waste. This theme is developed in the emphasis on how quickly Lady Capulet (Eden Epstein) was was made a wife and mother (younger than Juliet, and based on the text she could be as young as 26). This comes through in her subtle portrayal of depression at the thought of lost youth and cowardice in the face of her much older husband.

Jupe’s performance is standout. He is able to capture a contemporary take on the lines without losing any of their rhythm and poetry. This is in contrast to Sink, whose staccato delivery and frequent line breaks (perhaps emphasised by the American accent) jar against the poetry.

Kasper Hilton-Hille’s Mercutio – Romeo’s closest confidant – is a convincingly arrogant scamp. Throughout the production he is an active agent of chaos, always looking for trouble, mooning the Nurse and shaking his crotch at the fiery Tybalt (Aruna Jalloh). In fact he has been so relentlessly seeking out trouble across every timeline explored, that it is curious when in his death throes he calls down a plague on both the houses of Montague and Capulet. Surely he himself is to blame for his own demise?

My one criticism of the use of the multiverse in this production relates to the parts of the plot in which it is deployed. Often, Icke’s alternate timelines relate to chance, rather than the decisions made by the characters. For example, a drink is accidentally spilled, preventing Tybalt from attacking Romeo before he meets Juliet at the party. Or a messenger evades quarantine and delivers a letter informing Romeo that Juliet is actually still alive.

But what if it was the decisions of the characters that played out instead? For example, it would have been interesting to see Romeo not take revenge on Tybalt because he values his duty to Juliet over Mercutio. This would elevate the importance of the actions we take over the randomness of external factors. By emphasising happenstance over agency, Icke’s multiverses situate humans as flotsam on the waves of fate.

A more powerful call to action in our turbulent times would be to emphasise that it is the choices we make that can shape whether our story is a comedy or a tragedy.

Romeo and Juliet is at the Harold Pinter Theatre, London until June 20.

The Conversation

Will Shüler does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Romeo and Juliet: a ‘Sliding Doors’ production that plays with time to explore what might have been – https://theconversation.com/romeo-and-juliet-a-sliding-doors-production-that-plays-with-time-to-explore-what-might-have-been-281156

Asha Bhosle: the bad sister whose singing opened up a world of queer possibility for me

Source: The Conversation – UK – By Priyal Chitale, CHASE AHRC Doctoral Researcher and PhD student in the Department of Music, SOAS, University of London

Asha Bhosle, the last surviving singing legend of the golden era of Hindi cinema, has died at 92. She debuted in the industry shortly after Indian independence in the late 1940s and is now widely considered the best-known singer in India, with more than 12,000 songs to her name. Over the course of a long and prolific career, she demonstrated extraordinary enthusiasm for reinvention, and a range and versatility that still remain unmatched.

Fans of Bhosle found joy in her singing and intrigue in her tumultuous love life. She was often associated with the trope of the fallen woman in the public imagination and pitted against her singing elder sister, Lata Mangeshkar, who famously did her best to steer clear of “vulgar” songs and was seen to embody piety, modesty, and self-sacrifice.

The painting of Mangeshkar’s good sister to Bhosle’s bad reflected the distinct categorisation of female characters as either submissive women of virtue or self-serving women of vice, which prevailed in Hindi cinema well into the 1980s. This was mapped onto the singing voices of the sisters by music directors. For instance, Anil Biswas, the pioneer of playback singing, quipped that “Asha has body while Lata has soul”.

However, it was precisely this penchant for breaking the rigid bonds and boundaries of acceptable femininity that always drew me, as it did many other queer south Asian misfits, to Bhosle’s songs.

Possibility and Plenitude

Bhosle belonged to the first generation of star playback singers. These were singers who record songs for actors to lip synch over in films – a common practice in south Asian cinema. Although she was behind the scenes, the quality of her singing made her, in many cases, more famous than the actors who mimed along to her voice.

The hundreds of songs Bhosle sang in the voice of “the other woman” moved sapphic (women and non-binary people who are attracted to women) listeners like me not because they were literally addressed to women, but because they gave voice to women whom Hindi cinema often treated as excessive, dangerous or disposable.

The actors who lip-synched her pre-recorded vocals on screen were frequently women who stood just outside the moral centre of the film: cabaret dancers, courtesans, mistresses, club performers and women whose desire was too intense to be easily domesticated. In their films, such women were often punished, abandoned or contained. In Bhosle’s voice, however, they became vivid, thinking, feeling subjects.

This is why Aao Huzoor Tumko from romantic thriller Kismat (1968) is so revealing. Sung by Bhosle, composed by O.P. Nayyar and written by Noor Devasi, the song is an invitation into intoxicated romance during a seduction scene in the film. Its refrain may be translated as: “Come, my lord, let me take you among the stars; let me take you into such springtime that your heart begins to sway.”

The actor Babita Kapoor performs the song on screen for her beloved, who is played by the debonair Biswajit Chatterjee. But what I hear in Bhosle’s performance is not simply a woman offering herself to a man. I hear a woman luxuriating in the textures of her own desire.

Bhosle laughs, hiccups, sighs and croons languorously through the song. These are not merely ornamental flourishes, but also small acts of vocal acting: ways of turning a film song into a miniature performance of mood, body and selfhood.

When she lingers on the word “mein” (“in” or “into” ) in phrases such as “sitaron mein le chalun” (“let me take you among the stars”), “baharon mein le chalun” (“let me take you into springtime”) and “hazaaron mein le chalun” (“let me take you among thousands”), she makes each repetition feel slightly different. She carefully infuses each “mein” with a distinctive flavour of longing, turning an intoxicated declaration of desire into an intoxicating invitation into female interiority.

For me, the space of this song was never only straight. The song invited me into an elsewhere: into stars, springtime, crowds, intoxication, laughter and the strange privacy of a woman’s pleasure. It allowed me to imagine desire not as shame, sin, or plot device, but as atmosphere. This is what Bhosle so often made possible: the reimagining of a spectacle of seduction as a scene of emotional complexity.

Poster for Kismat 1968.
Asha Bhosle recorded songs for Kismat (1968)
Wikimedia, CC BY

Bhosle herself seemed to understand the power of such performances. In later years, when asked to name her favourite actor to sing for, she chose Helen, who appeared in countless films as a dancer. She remembered Helen as so beautiful that she would stop singing when she entered the room, and joked that, had she been a man, she would have eloped with her.

To me, this felt like a gift to queer women: not because the remark makes Bhosle queer in any simple biographical sense, but because it acknowledged the force of female beauty, female performance and female fascination without embarrassment.

Bhosle did not merely sing women who desired men. She made female desire itself sound artful and alive: playful, pensive, hungry, theatrical, contradictory. In her voice, levity became a mode of serious identity construction, melancholy a means of knowing, and seduction something more than a narrative device designed to punish the woman who performed it. Time and again, she made room for coyness, brazenness, restlessness, satisfaction, anger and hunger to coexist within the same sonic space.

If the pure and pious heroines of Hindi cinema were often permitted only dignity and devotion, Bhosle’s women were granted appetite, ambivalence and ambition. Her singing offered us possibility and plenitude: complex ways of feeling, sensing and relating to love and life that the moral world of Hindi cinema could neither name nor contain.

Her singing was often sinuous and sensuous, and deliberately so, but it was also playful, pensive and passionate in equal measure. She embraced and enlivened the full spectrum of femininity, and rendered women profoundly, excitingly and almost achingly human in ways that were often unthinkable in the narratives that her songs animated. For me, she will always be the greater sister.

The Conversation

Priyal Chitale does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Asha Bhosle: the bad sister whose singing opened up a world of queer possibility for me – https://theconversation.com/asha-bhosle-the-bad-sister-whose-singing-opened-up-a-world-of-queer-possibility-for-me-281215

As Arctic waters open up, Canada must prepare for oil spills

Source: The Conversation – Canada – By Chunjiang An, Associate Professor, Building, Civil, and Environmental Engineering, Concordia University

Canada’s Arctic is opening faster than protection efforts are keeping pace. As sea ice declines, shipping is expanding across Arctic and sub-Arctic waters.

That may bring economic opportunities, but it also raises the risk of fuel spills and other pollution in some of the most fragile coastal environments on Earth. The real question is no longer whether the Arctic is at risk. It’s whether Canada is ready for the kind of spill response these places actually require.

The answer is: not yet.

Arctic conditions are changing. September sea ice extent fell from 7.05 million square kilometres in 1979 to 4.37 million square kilometres in 2023. Over the same period, Arctic shipping grew, with traffic in the region reaching 12 million nautical miles in 2022.

More open water means more vessel traffic, longer shipping seasons and more pressure on northern coastlines. It also means a higher chance that a marine accident could turn into a shoreline emergency.

Arctic shorelines aren’t easy places to clean up. Oil does not behave the same way in icy, remote and cold environments as it does in warmer waters. It can be trapped by sea ice, pushed onto shorelines, mixed into snow or persist in sediments and coastal habitats that recover very slowly.

Cleanup is also harder because responders, vessels and equipment may have to travel long distances, often with limited local infrastructure. Even methods that work elsewhere can become far less effective once ice, cold temperatures and remoteness are part of the picture.

Oil spills in the Arctic

In our recently published research, colleagues and I highlight the dangers oil spills pose in the Arctic and the steps policymakers need to take to prepare for them.

The federal government’s Oceans Protection Plan and Multi-Partner Research Initiative are important steps in the right direction. Research supported through these programs has helped improve understanding of spill impacts, response methods and decision-making.

Policies like the Canada Shipping Act and the Arctic Waters Pollution Prevention Act also provide an important regulatory base. Canada is not standing still. But being on the right track is not the same as being ready for an accident.

Preparing before a spill

Canada needs better shoreline vulnerability mapping for Arctic and sub-Arctic regions. Not every shoreline is equally sensitive, and not every place has the same ecological, cultural or community value. A spill near a harvesting area, a culturally important coastal site or a fish habitat used by a nearby community may cause damage far beyond what a standard response map can show.

Preparedness should identify which shorelines matter most, why they matter and what kind of response makes sense in each place. That means combining physical data with ecological, social and cultural knowledge.

Second, we need a better grasp of how oil moves and changes in Arctic coastal areas. Ice cover, water salinity, waves, shoreline slope and sediment type all affect where spilled oil goes and how long it stays. Without that knowledge, response plans can look good on paper but fail in practice. More research is needed on cold-region transport and the special challenge posed by oil mixed with snow and ice.

Third, we need cleanup tools designed for these environments, not borrowed from somewhere else and assumed to work.

Our research points to the need for low-toxicity shoreline cleaners made from more environmentally friendly materials, along with treatment methods that avoid creating secondary waste during cleanup. Being ready for spills should not just mean faster response. It should also mean a safer and more sustainable response.

Indigenous communities vital

Most importantly, Canada’s Arctic cannot adequately prepare for spills without Indigenous partnership at the centre of planning. Many Indigenous communities are located along Canada’s coast, and about 75 per cent of the country’s coastline lies along the Arctic Ocean.

These communities are often among the first to face the effects of shoreline pollution, whether through impacts on food harvesting, water safety, coastal use or culturally important places.

My ongoing research looks into how shoreline protection can be improved through community-led monitoring, local training and stronger participation in governance. Those are not optional add-ons. They are part of what real preparedness looks like.




Read more:
Canada’s Arctic security depends on more than defence — here’s how immigration could help


That also means respecting Indigenous knowledge in spill planning and response. By bringing Indigenous knowledge and western science together to guide shoreline protection, governments can identify culturally important areas and support better responses. In the Arctic, local knowledge is not just helpful; it’s essential operational knowledge.

If Canada wants to open up its Arctic waters to more shipping, it must also prepare for accidents. That means investing in prevention, local capacity, science, Indigenous partnership and region-specific cleanup tools before the next major spill happens, not after.

Canada has made meaningful progress. But there is still a long way to go. A truly spill-ready Arctic will depend on governments, researchers, responders, industry and communities working together, with northern and Indigenous communities treated not as voices on the sidelines, but as core partners in protecting the coast.

The Conversation

Chunjiang An receives funding from the Natural Sciences and Engineering Research Council of Canada and Natural Resources Canada.

ref. As Arctic waters open up, Canada must prepare for oil spills – https://theconversation.com/as-arctic-waters-open-up-canada-must-prepare-for-oil-spills-280010

New test promises to detect cancer earlier — from tiny particles in bodily fluids

Source: The Conversation – Canada – By Sara Hassanpour Tamrin, Postdoctoral Associate, Department of Chemical and Petroleum Engineering, Schulich School of Engineering, University of Calgary

Cancer claims more than 10 million lives every year globally. Research shows that detecting cancer early can greatly improve a patient’s chance of survival. And yet we lack reliable, affordable tools for early detection.

Scientists are now discovering that our bodies may carry early warning signals packaged within tiny, bubble-like particles that circulate in bodily fluids like blood.

In the Schulich School of Engineering at the University of Calgary, we are developing a new technology to capture these particles and read their signals. Our recent work suggests that the electrical signals of these particles could offer a fast, label-free way to use them for diagnostic applications.

Our goal is to develop simple and non-invasive tests for early cancer detection.

Sara Hassanpour Tamrin presents an overview of her research during the Falling Walls Science Summit 2024 in Berlin.

The challenge of early detection

When cancer is found earlier, physicians can start treatment sooner. This helps to save more lives and lower health-care costs for both families and health-care systems.

However, many cancers are still not diagnosed until they are at an advanced stage. This is often because patients are either asymptomatic or dismiss their symptoms because they ascribe them to less serious causes.

Physicians often use bodily fluid tests to look for hidden warning signs in people who do not yet show symptoms of disease. These tests search for special substances (called biomarkers) that cancer cells release into bodily fluids like blood. But most of these biomarkers are rare and do not last long in the body during the early stages of cancer. Because of this, simple blood or urine tests are less reliable for early cancer detection.

What is needed is a simple tool that is cost-effective and can detect new, more robust biomarkers that current tests are unable to detect. It could then be added to the slate of analyses that are routinely run on bodily fluids.

Our interest in this challenge began with a simple question: What if cancer cells were already sending us quiet hints? Messages we had not yet learned to hear? Learning to detect and interpret these signals could enable earlier detection and help change the story for cancer patients.

Reading cancer’s secret language

Whether they are healthy or not, cells in our bodies are constantly communicating, almost like they are “talking” to each other. One way they do this is by packaging messages into tiny, bubble-like particles known as small extracellular vesicles.

A coloured drawing of cells sending and receiving information to each other.
Cells communicate by sending tiny message particles from one cell to another.
(Sara Hassanpour Tamrin)

The messages in these particles can be in the form of genetic material and other biomolecules.

These particles are released by cells into bodily fluids, which, much like a natural postal system, carry and deliver them to target cells, which read the messages and respond to the information they’ve been given. If we can capture these tiny particles from the bodily fluids and analyze their contents, it should provide us with a snapshot of the health of the cells that made them.

When these particles are released from cancer cells, they carry disease-related information both inside them and on their surface. What makes them especially promising for early cancer detection is that they can appear in bodily fluids long before other biomarkers that have traditionally been used to detect cancer. Often this is well before symptoms begin.

This understanding led our team at the University of Calgary to explore ways to collect these tiny particles from bodily fluids and translate their messages into signals that could help physicians detect cancer sooner and make earlier, more informed treatment decisions.

A novel technology to capture these particles

Although small extracellular vesicles hold great promise for early cancer detection, finding these tiny particles in bodily fluids is not straightforward. They are extremely small, about 500 times smaller than a typical pollen grain, and are mixed with many other components in complex fluids like blood and urine.

As a result, isolating them in a reliable way, without damaging them or losing important information, has been a major scientific challenge.

A prototype device with wires, test tubes and electrical current.
A prototype device that uses gentle electrical forces to separate and purify these tiny particles from biological fluids.
(Sara Hassanpour Tamrin)

One important idea in this field is to study these particles in their natural state, without adding foreign molecules like antibodies as labels that may alter their properties. As we discussed in a review article, this kind of approach helps preserve the true signals these particles carry and allows for more accurate analysis.

Building on this, we developed a new technology that uses the natural electrical properties of these particles to capture them directly from bodily fluids.

This technology gently collects these particles using electrical force and preserves the information they carry. This represents a new direction in how we study these particles for diagnostic applications. The technology is patent pending.

From lab research to real-world impact

We are now working to bring our new technology, EXOSense, from the lab into real-world diagnostic tools.

EXOSense captures tiny particles and reads their signals to help find cancer sooner.
(Sara Hassanpour Tamrin)

The EXOSense platform is still under development and needs to be tested with patient samples. It could make a meaningful difference in people’s lives through simple liquid biopsy tests. Much of our work focuses on developing miniaturized platforms, using microfluidic technology, that are both user-friendly and cost-effective.

This approach aims to improve access to diagnostic tools, particularly in under-served communities with limited laboratory infrastructure. Over time, we anticipate this work will lead to a new test that can detect cancer early using just a drop of biofluid and will contribute to reducing the burden of cancer.

The Conversation

Sara Hassanpour Tamrin receives funding from Banting Postdoctoral Fellowship program, supported by the Natural Sciences and Engineering Research Council of Canada (NSERC). She previously received support through the Alberta Innovates Postdoctoral Fellowship program.

Arindom Sen receives funding from the Natural Sciences and Engineering Research Council of Canada (NSERC).

ref. New test promises to detect cancer earlier — from tiny particles in bodily fluids – https://theconversation.com/new-test-promises-to-detect-cancer-earlier-from-tiny-particles-in-bodily-fluids-280663