Category: Analysis

Source: The Conversation – UK – By Rob Morris, Professor of Physics, School of Science and Technology, Nottingham Trent University

The 2025 Nobel prize in Physics has been awarded to three scientists for the discovery of an effect that has applications in medical devices and quantum computing.

John Clarke, Michel Devoret and John Martinis conducted a series of experiments around 40 years ago which would go on to shape our understanding of the strange properties of the quantum world. It’s a timely award, since 2025 is the 100th anniversary of the formulation of quantum mechanics.

In the microscopic world, a particle can sometimes pass through a barrier and appear on the other side. This phenomenon is called quantum tunnelling. The laureates’ experiments demonstrated tunnelling in the macroscopic world – in other words, the world that’s visible to the naked eye. They showed that it could be observed on an experimental electrical circuit.

Quantum tunnelling has potential future applications in improving memory for mobile phones and has been important for the development of “qubits”, which store and process information in quantum computers. It also has applications in superconducting devices, those that conduct electricity with very little resistance.

British-born John Clarke is Professor of Physics at the University of California, Berkeley. Michel Devoret was born in Paris and is the F. W. Beinecke Professor of Applied Physics at Yale University. John Martinis is Professor of Physics at the University of California, Santa Barbara.

What is quantum tunnelling?

Quantum tunnelling is a counter-intuitive phenomenon where the tiny particles which make up everything we can see and touch can appear on the other side of a solid barrier, which you would otherwise expect to stop them.

Since it was first proposed in 1927, it has been observed for very small particles and it is responsible for our explanation of the radioactive decay of large atoms into smaller atoms and something else called an alpha particle. However, it was also predicted that we might be able to see this same behaviour for larger things. We call this macroscopic quantum tunnelling.

How can we see quantum tunnelling?

The key to observing this macroscopic tunnelling is something called a Josephson junction, which is essentially a fancy broken wire. The wire is not a typical wire which you might use to charge your phone, instead it is a special type of material known as a superconductor. A superconductor has no resistance, which means that a current can flow through it forever without losing any energy. They are used, for example, to create the very strong magnetic fields in magnetic resonance imaging (MRI) scanners.

So how does this help us to explain this strange quantum tunnelling behaviour? If we put two superconducting wires end to end, separated by an insulator, we create our Josephson junction. This is normally manufactured in a single device which, with a basic understanding of electricity, shouldn’t conduct electricity. However, thanks to quantum tunnelling we can see that current can flow across the junction.

The three prize winners demonstrated quantum tunnelling in a paper published in 1985 (it’s common to have such large gaps in time before Nobel prizes are awarded). Quantum tunnelling had previously been suggested to be caused by a breakdown in the insulator. The researchers started by cooling their experimental apparatus to within a fraction of a degree of absolute zero, the coldest temperature which can be achieved.

Heat can give the electrons in conductors just enough energy to get through the barrier. So it would make sense that the more the device is cooled, the fewer electrons would escape. If however quantum tunnelling is taking place, there should be a temperature below which the number of electrons which escape should no longer decrease. The three prize winners found exactly this.

Why is this important?

At the time, the three scientists were trying to prove this developing theory about macroscopic quantum tunnelling through experiments. Even during the announcement of the 2025 prize, Clarke downplayed the importance of this discovery, even though it has been pivotal in so many developments which are at the forefront of quantum physics today.

Quantum computing remains one of the most exciting opportunities which is promised for the near future, and is the source of significant investment worldwide. It comes with much speculation about the risks to our encryption technologies.

It will also ultimately solve problems which are outside the reach of even the largest of today’s supercomputers. The handful of quantum computers which are in existence today, rely on the work of the three 2025 physics Nobel laureates and no doubt will be the subject of another physics Nobel prize in the coming decades.

We are already exploiting these effects in other devices such as superconducting quantum interference devices (Squids) which are used to measure small variations in magnetic fields from the Earth, allowing us to find minerals below the surface. Squids also have uses in medicine. By detecting extremely weak magnetic fields, they can improve on the images from MRI and provide high resolution images of tumours. They can also be used to map electrical activity in the brain, helping to manage epilepsy.

We can’t predict if and when we will have quantum computers in our homes, or indeed in our hands. One thing that is for certain, though, is that the speed of development of this new technology is thanks in no small part to the winners of the 2025 Nobel prize in physics, demonstrating macroscopic quantum mechanical tunnelling in electric circuits.

Rob Morris does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Nobel physics prize awarded for pioneering experiments that paved the way for quantum computers – https://theconversation.com/nobel-physics-prize-awarded-for-pioneering-experiments-that-paved-the-way-for-quantum-computers-266911

Source: The Conversation – UK – By Kirsten Antoncich, Senior Lecturer in Psychology, Birmingham City University

Developmental research often tells us how ego centric children are. Yet all too often we hear of children who are forced to demonstrate great courage and care in in a crisis.

The ongoing inquiry into the 2024 mass stabbing of young girls in Southport, England, has produced accounts of extreme bravery among the children subjected to the attack. Indeed, the report of a child standing in front of her sister to protect her from knife blows shows a level of courage many adults might not have possessed in the same circumstances.

Details have also emerged of young children holding the door open to allow other children to escape from their attacker first and of children helping others not draw attention to themselves by running or screaming. Similar accounts often emerge from school shootings in the US – take, for example, the report of a teenager confronting a gunman who attacked pupils at a high school in Colorado in September 2025.

How could such young people conduct themselves with so much composure and selflessness? Psychological research shows that children develop the cognitive, personal and emotional skills needed earlier than people might realise.

Although much of our understanding of human courage comes from the adult field, developmental psychology professor Peter Muris’s 2009 study examined the link between fear and courage in children aged eight to 13. His interviews and studies with his young participants found there may be a link between increased courage and the personality traits of extroversion, openness and intellect.

He also found 94% of the children in his study had already carried out at least one courageous action in their lives, such as dealing with an animal they were afraid of or defending a friend from bullies.

And a 2021 study found that extroversion in teenagers seemed to protect them from developing anxiety. It could be that many of the young children who have acted bravely in a crisis had higher scores of this protective trait.

Experimental psychologist, Joana Viera, and her colleagues in their 2020 study explored how humans react when faced with a threat in the form of an electric shock and the option to help another person avoid the shock. They found that as the likelihood of the threat increased, humans were more likely to go to the aid of another, even at risk of a shock to themselves. Their study suggests that defensive states of mind also activate cognitive processes which promote care giving.

Psychologists Tony Buchanan and Stephanie Preston explored how stress can promote altruism, in their 2014 analysis. They emphasised that the neural circuits that support care-taking under stress overlap with brain circuits associated with reward and motivation. These two areas act together during times of stress, helping shift the persons response away from avoidance of threat towards the protection of others.

This care taking mechanism is seen in many animals from rats to gorillas. Social psychologist Daniel Batson suggested there are two types of responses to acute threat, one motivated from personal distress which is self focused and another based upon sympathetic or empathic responding linked to altruism. We all have the potential to respond in either way, which makes the courage of these children all the more impressive.

Several psychologists have found children as young as 12 months old can recognise and respond with empathy to distress in other humans. A 2011 study found that children as young as two years old could respond to others’ distress with verbal comfort, advice and distraction. The researchers also demonstrated that infants responded with heightened distress when presented with the sounds of distress in others.

In order to remember instructions and to show higher order skills such as empathy and the care of others over oneself, the children needed to draw on their developing executive function and areas of the brain’s limbic region. This system is a group of connected brain structures that helps regulate emotions and behaviour. These areas are typically fully developed by young adulthood.

In the stories that have emerged, you can hear how the children seem to have internalised advice from adults about how to act in an emergency. Repeated instructions are actually easier to recall under acute stress.

These structures are developing throughout childhood. But research has persistently shown that children of preschool age perform executive functioning tasks such as the ability to perceive and respond to another person’s emotional state. Rather than respond from a instinctive fight or flight response, the children who stay calm during critical moments contain their fear enough to care for others.

A 2010 study investigated the areas of the brain in adults associated with increased bravery. Participants with a fear of snakes had to bring a live snake close to their head. The study found courage was associated with the dissociation of fear and sensory arousal. This means that those people who show courage during stressful situations may disconnect from their feelings of fear and their physiological experiences of fear in the body.

The combination of dissociation and instruction retrieval could help explain how they were able to stay so calm and come to the aid of others. Indeed, caring for others in times of distress can distract us from our own acute distress.

Self efficacy, or the ability to act during times of threat can also protect people against the development of post traumatic symptoms. And a 2019 study found that positive traits such as hope, competence and optimism may also protect people against the development of post traumatic stress disorder.

In all instances where children are faced with such great adversity, one can only hope the bravery and mastery they show offers some protection against the immense psychological trauma the endure.

Kirsten Antoncich does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Children are capable of extreme bravery from a young age – a psychologist explains how – https://theconversation.com/children-are-capable-of-extreme-bravery-from-a-young-age-a-psychologist-explains-how-265523

Source: The Conversation – UK – By Amy Burge, Associate Professor in Popular Fiction, University of Birmingham

The author Jilly Cooper has died aged 88. Cooper’s books were “bonkbusters” – a form of blockbuster fiction that was most popular in the 1980s and 1990s, characterised by explicit sex, scandalous plots and large casts of characters.

In her 1993 novel, The Man Who Made Husbands Jealous, a reporter rings famous singer Georgie to tell her that her husband Guy had been voted “hubby of the year”. She elaborates: “To be quite honest there wasn’t a lot of choice. Faithful husbands are an endangered species.” This quote is emblematic of the writing that made Cooper famous. It’s full of irreverent wit, tongue-in-cheek scrutiny of British society – and misbehaving men.

Cooper was one of the four major bonkbuster authors, alongside Jackie Collins, Shirley Conran and Judith Krantz. Her racy, ribald romps through the fictional county of Rutshire reached millions of readers. And as we discovered when talking with bonkbuster readers while researching our forthcoming book, they continue to be beloved by many.

The author was born in Essex on February 21 1937, educated in Yorkshire and Wiltshire, and, at the age of 20, became a junior reporter for The Middlesex Independent. This was the beginning of what would be a highly successful career in journalism. Cooper went on to write long-running columns in The Sunday Times Magazine and The Mail on Sunday, which offered a light-hearted look at women’s domestic lives.

These columns formed the basis of many of her non-fiction books, such as How to Stay Married (1969) and How to Survive from Nine to Five (1970).

However, she was also busily writing fiction, and after some success publishing short fiction in magazines, Cooper published a series of romantic novels in the 1970s and 1980s, all with women’s names in their titles.

These works offered an account of the urban zeitgeist for young single women of the time, discussing issues like rape, marriage, pregnancy and careers.

But Cooper is best known for her Rutshire Chronicles (1985-2023), a classic bonkbuster series set in the Cotswolds. Characterised by her trademark tongue-in-cheek style, the 11 novels in the series share a huge cast of characters – anchored around the arrogant, irresistible Rupert Campbell-Black – and a wide range of settings.

These books are best known, in the words of one of the readers we talked to, as “full, fat, fun, frothy novel[s] set around class and privilege and horses”. Many of the Rutshire Chronicles blend interpersonal drama with the social drama of the equestrian world: from show-jumping and sex in Riders (1985), polo and illegitimate daughters in Polo (1991), and horse racing and even more sex in Jump! (2010) and Mount! (2016).

However, horses weren’t the only focus. Other novels in the Rutshire Chronicles explored regional television rivalries, bad husbands and infidelity, orchestral drama, murder and opera, art theft, British schools and premier league football.

Sex is good for women (or should be)

Cooper’s books are famous for their sex scenes. From the scandalous (the naked tennis match in Rivals) to the sticky (characters using grass to wipe themselves clean after an al fresco romp), she did not shy away from putting sex on the page.

Many of Cooper’s depictions of sex are very funny. However, there is a clear message throughout – women are entitled to good sex, and it is the job of their (usually male) partners to give it to them.

Rupert Campbell-Black is Cooper’s most famous stud (horses aside), but he is very bad at satisfying his first wife Helen. In Riders, Cooper wrote that Helen “longed for love but, having been married to Rupert for six and a half years … felt she had become what he kept telling her she was: boring, prissy, brittle and frigid”. However, the problem is not Helen. With a different, more attentive partner – Rupert’s rival Jake – Helen has a sexual awakening.

The entire premise of The Man Who Made Husbands Jealous revolves around male neglect (sexual and otherwise). Unsatisfied wives engage the services of a man named Lysander in the hope that some competition will reengage their neglectful, philandering husbands.

Along the way, they have considerably better sex with Lysander, whose consideration in bed has his partners “bubbling like a hot churn of butter”. The titular husbands eventually learn that they must do better in order to keep their wives, sexually and otherwise.

Sex aside, what became clear from our research was how much Cooper’s works meant to their readers. Former prime minister Rishi Sunak might be Jilly Cooper’s most famous reader, but many of the readers we spoke to were particularly fond of her books, re-reading them repeatedly for comfort and familiarity. One described her books as “like a friend”.

For some, the appeal was escapism “into this incredibly glamorous world that you … could have some ambition of being part of yourself when you grew up”. For others, Cooper’s books were educational, teaching readers about how to navigate the unfamiliar world of the British upper classes, or providing a form of sex education. Several of our readers noted the unusual (for the time) frankness of Cooper’s novels.

Cooper was the last living “big four” bonkbuster author. Her death marks the end of an era. However, the recent television adaptation of Rivals seems to have attracted a new audience. Filming for a second season commenced in May 2025 – it seems Cooper’s stories live on.

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The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

– ref. Jilly Cooper: why readers still cherish her ‘fat, fun, frothy novels’ – https://theconversation.com/jilly-cooper-why-readers-still-cherish-her-fat-fun-frothy-novels-266881

Source: The Conversation – UK – By Justin Stebbing, Professor of Biomedical Sciences, Anglia Ruskin University

The 2025 Nobel Prize in Physiology or Medicine celebrates a discovery that answers one of medicine’s most profound questions: how does the immune system know when to attack, and when to stand down?

Most of the time, our defences target dangerous infections and even cancers while leaving the body’s own tissues unharmed. But when that balance fails, the consequences can be devastating – from autoimmune diseases, where the immune system turns on healthy organs, to cancers, where it becomes too restrained to recognise and destroy tumour cells.

Read more:
Nobel prize awarded for discovery of immune system’s ‘security guards’

Three scientists – Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi – uncovered how our bodies maintain this delicate control through a special class of immune cells called “regulatory T cells”. Their discovery revealed the immune system’s natural “brakes”: the internal mechanisms that prevent friendly fire but, in some cases, can also shield cancers from attack.

Understanding how these brakes work has already reshaped modern immunology. The same insight guiding new treatments for autoimmune diseases is now helping researchers fine tune cancer immunotherapies; adjusting the immune system’s restraint so it hits hard against tumours without turning against the body.

The immune system works like a highly trained security force, patrolling every corner of the body to detect and destroy bacteria, viruses and rogue cells. But even the best security team can be dangerous without oversight.

Left unchecked, immune cells can mistakenly attack healthy tissue: the hallmark of autoimmune diseases such as type 1 diabetes or multiple sclerosis. And when the system becomes too cautious, it can overlook genuine threats, giving cancers the chance to grow unnoticed.

For decades, scientists thought most of this immune “training” happened early in life, inside an organ called the thymus: a small gland above the heart where young immune cells learn which targets to attack and which to ignore. Those that fail this test are eliminated before they can cause harm.

But in the 1990s, Japanese immunologist Shimon Sakaguchi discovered there was more to the story. Through experiments on mice, he identified a previously unknown type of immune cell called a “regulatory T cell”: the peacekeepers of the immune system. These cells don’t attack pathogens themselves.

Instead, they hold the rest of the immune army in check, preventing unnecessary destruction. When Sakaguchi removed these cells in laboratory animals, their immune systems spiralled out of control, launching attacks on healthy organs. His work showed that these peacekeeping cells are essential for preventing the body from waging war on itself.

A few years later, Mary Brunkow and Fred Ramsdell found the genetic switch that makes these peacekeepers possible. They discovered that a single mutation in a gene called Foxp3 could leave both mice and human babies vulnerable to a rare but devastating autoimmune disorder called IPEX syndrome. The Foxp3 gene acts as the “on switch” for producing regulatory T cells. Without it, the immune system loses its referees and chaos follows.

T helper and regulatory T cells

The immune system relies on many types of T cells. T helper cells act as team captains, directing other immune cells to respond to infections. Much of my own research has focused on how these cells behave in HIV infection, where their loss leaves the immune system defenceless. Regulatory T cells belong to this same family but serve the opposite role: they calm things down when the fight goes too far.

These peacekeepers keep the immune defenders focused on real threats rather than friendly targets. When they fail, autoimmune diseases emerge. But when they work too well, they can suppress immune attacks on cancer, allowing tumours to hide and grow. Scientists are now learning how to fine-tune this balance: boosting the guards to control autoimmune disease, or easing the brakes so the body can fight back against cancer.

These discoveries have redefined how doctors think about immunity. Clinical trials are already testing therapies that expand regulatory T cells in people with arthritis, diabetes or after an organ transplant; helping the body to tolerate its own tissues.

In cancer treatment, the opposite approach is used: blocking or disabling these peacekeepers to unleash a stronger immune attack on tumours. This is the principle behind modern immunotherapies, which have already transformed outcomes for patients with melanoma, lung cancer and lymphoma.

Science that touches lives

The work of Brunkow, Ramsdell and Sakaguchi shows how basic science can lead to profound changes in medicine. Their discoveries help explain not just why the immune system sometimes goes wrong, but how it can be guided back into balance – a balance that could one day prevent autoimmune diseases, improve transplant survival and make cancer therapies both safer and more effective.

The Nobel committee’s decision this year recognises not only their scientific achievement, but also a vision of the immune system as something far more nuanced than an on-off switch. It’s a finely tuned orchestra and regulatory T cells are its conductors, ensuring the right notes are played at the right time, silencing those that might cause chaos.

By learning to adjust these biological “brakes” with precision, medicine is entering a new era. Treatments inspired by these discoveries are already improving lives and may, in time, transform how we prevent and treat disease across the spectrum, from autoimmunity to cancer.

Justin Stebbing does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Nobel Prize: how a hidden army in your body keeps you alive – and could help treat cancer – https://theconversation.com/nobel-prize-how-a-hidden-army-in-your-body-keeps-you-alive-and-could-help-treat-cancer-266860

Source: The Conversation – UK – By Sam Fankhauser, Professor of Climate Economics and Policy, Smith School of Enterprise and the Environment, University of Oxford

In the mid-2000s, soon after becoming Conservative leader, David Cameron hugged a husky on a trip to the Arctic, in what was widely described as an attempt to “detoxify” the Tory brand. Eighteen years later, Kemi Badenoch has promised to scrap the law that once made that rebranding credible.

Her announcement that the Conservatives will repeal the 2008 Climate Change Act if they win the next general election has the potential to be a major own goal – politically, environmentally and economically.

To understand why, we need to remember how the Climate Change Act came about. The bill was put forward by the Labour government of Gordon Brown, but it had enthusiastic support from the Conservative opposition, which tabled several amendments to strengthen it. Cameron had concluded that green policies were a good way to modernise his party and lead it back into power.

It worked, both for Cameron, who became prime minister in 2010, and for UK climate policy, which has enjoyed a unique period of consensus and stability. Over seven governments, multiple economic crises, Brexit, COVID-19 and the war in Ukraine, there has been clarity about Britain’s climate change objectives. Policies were chopped and changed, often to the frustration of investors, but the institutional framework was stable and widely appreciated.

The Climate Change Act gives the UK a statutory long-term emissions target – initially an 80% cut from 1990 levels by 2050, strengthened to net zero by 2050 by Theresa May, another Tory prime minister.

Progress is managed through a series of five-year carbon budgets, legislated 12 years in advance and monitored by a powerful independent body, the Climate Change Committee (CCC). For much of its existence, the CCC has been chaired by yet another environmentally-minded Tory, Lord Deben (John Gummer). It is this framework the Conservatives now say they want to dismantle.

Yet the Climate Change Act has delivered, both in terms of process and substance. Indeed, the UK model has been emulated around the world. Nearly 60 countries have UK-style climate change laws and over 20 countries have CCC-style advisory bodies, cementing the UK’s position as a climate leader.

The act gives the UK a steady institutional rhythm. Relevant businesses and other organisations know the formal set pieces, such as the CCC’s annual report to parliament, and can time their interventions accordingly.

When colleagues and I interviewed people from business and civil society about the act a few years ago, they emphasised the predictable process, the clear rules on accountability and the evidence-based discourse it has enabled. This all reduces uncertainty and enables long-term planning.

Importantly, the Climate Change Act has delivered environmentally too. Compared to 1990, UK greenhouse gas emissions are down by 50%. The UK economy now uses three times less carbon per unit of economic output than in 1990. Emissions are at their lowest level since 1872.

This trend started before the act, but it was helped and accelerated by it. This is perhaps most noticeable in the radical transformation of the electricity sector: coal has been completely phased out, while offshore wind and other renewables have flourished.

Most people want climate action

Voters value this progress more than politicians appreciate. A University of Oxford survey found that internationally public support for climate action is almost twice as high as policymakers assume. In the UK, three out of four people are fairly or very concerned about climate change.

Badenoch’s announcement comes just as households are starting to reap the financial benefits of clean technology. Colleagues and I have estimated that four out of five UK households, particularly those owning a car, would be better off if net zero was achieved. The typical savings are £100-£380 per household and year.

It is true that households do not yet see the benefits of renewables on their energy bills. We are still paying for the high costs of early investments in clean power, before technology and sheer scale brought the price down.

Successive governments have chosen to recoup these learning costs through electricity bills, rather than general taxation, which would have been easier on most households. But recent analysis suggests renewables are now cutting electricity prices by up to a quarter.

Read more:
We surveyed British MPs – most don’t know how urgent climate action is

The policy uncertainty generated by the Tory announcement and similar pronouncements by Reform UK will eventually find its way into the risk premiums for investors, though for the time being this effect is still small.

But the reputational damage is immediate. Undoing the act would signal that the UK no longer values the long-term stability that has driven clean investment and made its climate policy admired around the world.

Climate policy requires debate. Deeply political choices need to be made about different decarbonisation strategies, how to pay for necessary investments or the role of controversial technologies like nuclear energy. The past 17 years have shown that these debates are best had within an agreed framework, with support from all major parties. That is what the Climate Change Act provides.

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Sam Fankhauser does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

– ref. Tory plan to scrap net zero target puts UK climate leadership at risk – https://theconversation.com/tory-plan-to-scrap-net-zero-target-puts-uk-climate-leadership-at-risk-266853