Oscar contenders and women of substance – what to watch, read and see this week

Source: The Conversation – UK – By Anna Walker, Senior Arts + Culture Editor, The Conversation

I just finished watching The Studio, Seth Rogen’s hilarious Apple TV satire of life inside an old school Hollywood production company. One of the standout episodes was set in the audience at the Golden Globes. It perfectly captures the peculiar theatre of awards shows: stars smiling and clapping furiously while hoping the person next to them loses.

It got me thinking about this weekend’s Oscars – who will be taking the big prizes, and who will be applauding graciously while quietly gnashing their teeth. In anticipation, I asked the arts team who or what they’d like to see winning on Sunday night.

I’d personally love to see Michael B. Jordan take home best actor. It’s a supremely competitive category this year, but his dual performance as identical twin brothers Smoke and Stack in Sinners blew me away. It’s testament to his talent that while watching I so easily forgot that such a recognisable actor wasn’t in fact two different people.

Naomi Joseph, arts and culture editor:

I would love to see The Secret Agent win. It’s a stylish and smart film that challenges its audiences while keeping them gripped. I baulked at the two-hour 40-minute length, but watching it, I was absorbed. The structure is inventive, the music is brilliant and the costume and set design are immaculate. It’s incredibly ambitious, and there are many things that shouldn’t work – like the meandering narrative and the abrupt tonal shifts – but everything comes together to make a complex yet coherent film. It is truly a masterpiece.

Jane Wright, commissioning arts editor:

An exquisite, wonderfully slow film, watching Hamnet is like walking through a painting. The pleasure is in the unfolding of its story, leading you in with visual delights, rich historical detail and moving performances. You could not help but weep at the final scene when the soaring strings of Max Richter’s On The Nature of Daylight rise as the camera fixes on Jessie Buckley’s face. She says nothing, but you are acutely aware of every thought going through her head. I think she’s extraordinary. Best film and best actress for me.

Life in the aftermath

No doubt some of the filmmakers and stars in attendance will use the opportunity to spotlight the ongoing conflict in Iran.

Now available for the first time in English, Women Without Men by Shahrnush Parsipur is an innovative feminist story set in Iran. The novel follows five women and the circumstances that lead them to leave their lives and begin again in a garden on the outskirts of Tehran.

Written in the immediate aftermath of the 1979 revolution, it was immediately banned on publication. Shortly afterwards, Parsipur was arrested and jailed for her frank and defiant portrayal of women’s sexuality.

The novel insists that authoritarianism doesn’t begin in the halls of power; it begins in the household, within layered patriarchal systems that confine women’s autonomy. Parsipur’s blending of realism and magical elements mirrors the instability of a society in crisis.




Read more:
Women Without Men: a novella that tells the history of Iran through women’s bodies


The legacy of another conflict is the subject of director Kei Ishikawa’s new adaptation of Kazuo Ishiguro’s first novel, A Pale View of the Hills.

The story unfolds across two timelines. England in the 1980s, where a mother and daughter struggle to come to terms with the suicide of the latter’s older half-sister; and Nagasaki in the 1950s, as the city grapples with the trauma of the atomic bomb.

Our reviewer, professor of Japanese studies Jennifer Coates, found the film to be a rich exploration of the atomic bombings of Japan and their continuing impact. She writes that the “subtle performances and beautiful cinematography of Ishikawa’s film create an inviting and nostalgic atmosphere that allows the disturbing themes of this important book to be gently drawn out”.




Read more:
A Pale View of Hills: the legacy of atomic bombings in Japan is explored in this adaptation of Kazuo Ishiguro’s first novel


Women of substance

A couple of weeks ago I went to the press preview of A Woman of Substance in Leeds. It was a treat to see the screening in my own city, especially as the series was largely set and filmed in Yorkshire.

Some subscribers may remember the first adaptation of Barbara Taylor Bradford’s novel, which aired on Channel 4 in 1985. The saga of Emma Harte – the Yorkshire maid who becomes one of the richest women in the world – was a ratings juggernaut.

The trailer for A Woman of Substance.

This new eight-part remake arrives with a curious mix of nostalgia and reinvention: an attempt to revive the glossy melodrama of the 1980s bonkbuster while reframing its heroine for a contemporary audience.

We asked television expert Beth Johnson, herself based in Leeds, what she made of the first episode. She thought the new adaptation looked well poised to replicate the addictive pacing that made Bradford’s novel such a phenomenon.

A Woman of Substance is streaming now on Channel 4




Read more:
A Woman of Substance: Channel 4’s lavish remake revives the pleasures – and contradictions – of the bonkbuster


The first photograph by Catherine Opie I ever saw was Self-Portrait/Cutting (1993). It’s a large print showing a child-like doodle: two stick women holding hands in front of a simple square house. What carved it into my memory was that this doodle was scratched into her skin. It remains one of the most evocative images of longing for a family that I have ever seen.

A new exhibition of Opie’s work – To Be Seen at the National Portrait Gallery – includes this print. The show places Opie’s portraits “in dialogue with the permanent collection” by hanging them side by side. For our reviewer, the curation “reminded me that the National Portrait Gallery was one of the first galleries I remember enjoying at 15 or 16. I loved it because there were faces everywhere. [And] the faces on the walls began to change how I saw the faces of the visitors in the gallery.”

Catherine Opie: To Be Seen is at the National Portrait Gallery until May 31




Read more:
Catherine Opie: To Be Seen at The National Portrait Gallery – a reminder of why we go to exhibitions in the first place


This article features references to books that have been included for editorial reasons, and may contain links to bookshop.org. If you click on one of the links and go on to buy something from bookshop.org The Conversation UK may earn a commission.

The Conversation

ref. Oscar contenders and women of substance – what to watch, read and see this week – https://theconversation.com/oscar-contenders-and-women-of-substance-what-to-watch-read-and-see-this-week-278229

What you study in school shapes your voting choices in adulthood

Source: The Conversation – UK – By Nicole Martin, Lecturer in Politics, University of Manchester

Shutterstock/Triff

Across Europe, education has become one of the biggest dividing lines in politics, and educational qualifications are now one of the best predictors of vote choice in Britain. This is particularly the case for new parties that compete more on cultural issues, including Reform and the Greens, who attract voters from different ends of the educational spectrum.

In the most recent UK general election in July 2024, 18% of voters with no formal qualifications voted for Reform – two and half times as many as among those with a degree. On the flip side, degree-holders were three times as likely to vote for the Green party than those without qualifications.

Our study shows that the link between education and politics starts far earlier than degree level, however. We’ve found that what you study at school affects your political choices both in adolescence and adulthood.

We looked at the political views of young people aged ten to 18, and then followed them into their 20s. Young people who were studying humanities subjects in school, namely history and art, became more likely to support more socially liberal parties.

Those studying a technical GCSE subject, such as design and technology, became more supportive of more radical right parties. Given that we see this pattern before students leave school, it can’t only be explained by socialisation in the workplace, which makes us think that at least part of the association emerges in school.

Taking a GCSE in business studies meanwhile meant that someone became more economically rightwing in their vote intention. When they were 16 and had finished their GCSE in business studies, these young people were two percentage points more likely to say they’d vote for the Conservatives than when they’d started at age 14. This might seem small, but small differences add up over the course of a person’s life.

People develop their political orientations during adolescence, so parental socialisation of course matters a great deal. But much of those formative years is also spent in the classroom. And a student of history encounters different ideas and develops different skills to one studying physics – even if they both eventually end up with the same number of GCSEs or A-levels, or a university degree.

For instance, a physics class might focus on the scientific marvel of splitting the atom and nuclear power, whilst a history student would consider the catastrophic effects of these weapons in the second world war. As a result, the history student and the physics student might emerge from their studies with different perspectives on the world, which might ultimately lead them to support different parties.

Two students studying, one looking into a microscope.

Shutterstock/Monkey Business Originals

It’s unlikely that these findings relate to teachers indoctrinating students into supporting particular parties or ideologies. It’s more likely that certain subjects that focus on different human experiences – such as history or art – might lead students to recognise the importance of a variety of perspectives, and so be more favourable towards socially liberal parties. Likewise, studying economics might incline a young person to support a party that champions free markets.

Alternatively, it could be explained by the differing peer groups across these subjects, whereby the attitudes held when students select into these subject are mutually reinforced.

We also found that the differences we identified persisted in early adulthood, long after school had finished. Adults who had taken drama, music, art or history were more likely to vote for socially liberal parties such as the Greens or Liberal Democrats.

Some of these differences were very large in adulthood, even when we adjusted for other factors that might explain them, like overall educational attainment and income. For example, an adult who had taken an A-level in economics or business studies was 14 percentage points more likely to support the Conservative Party and six points less likely to support Labour than someone who had not.

It’s also notable that students who took any of history, geography, foreign languages or religious studies were more engaged in politics. They were more likely to name a party they would vote for, rather than saying they wouldn’t vote.

Our findings may add a different angle to debates about curriculum reform. Recent governments have favoured increasing participation in STEM subjects, often to the detriment of subjects like the creative arts and languages. Our study suggests that this might in turn have consequences for young people’s politics.

Either way, our results show that what you learn in school is likely to shape your world view beyond the classroom.

The Conversation

Ralph Scott currently receives funding from the Leverhulme Trust and his research was previously funded by the ESRC.

Nicole Martin and Roland Kappe do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

ref. What you study in school shapes your voting choices in adulthood – https://theconversation.com/what-you-study-in-school-shapes-your-voting-choices-in-adulthood-273942

Why the Chagos Islands deal is delayed – and Mauritius is threatening to sue the UK

Source: The Conversation – UK – By Sue Farran, Professor of Comparative and Plural law, Newcastle University

More than a year ago, the UK agreed to grant Mauritius sovereignty over the Chagos Archipelago, which Britain has governed as the British Indian Ocean Territory since 1965. But the treaty to transfer sovereignty has hit choppy waters. The deal has stalled in the UK parliament and Mauritius has now threatened legal action against the UK over the delay.

For years, successive UK governments played the interests of the Chagossians off against those of Mauritius, to deflect potential threats to its control of the Chagos Islands. But just as that strategy has run out of road, the international legal order is under extreme pressure.

Last month, the US president, Donald Trump, declared that the UK was “making a big mistake” in relinquishing the Chagos Islands, one of which, Diego Garcia, hosts a US-UK military base. This appears to have been prompted by Keir Starmer’s reluctance to let the US use Diego Garcia for preemptive strikes against Iran. Starmer later changed his position, with the caveat that any strikes should be defensive. How that distinction is to be monitored, however, is debatable.

Trump long accepted the proposed UK-Mauritius treaty, even if it sat uncomfortably with his own desire for US territorial expansion. But he first appeared to change his tune in January, calling the deal “an act of great stupidity”.

Under the pressure of international politics and domestic opposition, the legislation supporting the deal to return the Chagos Islands to Mauritius has stalled. In January, a debate on the bill was pulled in the final stages, after the Conservative opposition tabled an amendment calling for a pause “in light of the changing geopolitical circumstances”. Its return for further debate is not yet scheduled.

Trump and Starmer speaking closely to each other at the White House
Trump has said that Starmer would be ‘making a big mistake’ by ceding sovereignty of the Chagos Islands to Mauritius.
Joshua Sukoff/Shutterstock

The treaty between the UK and Mauritius, which was ratified in May 2025, allows the UK to exercise control over the Diego Garcia base for a period of 99 years, with an option for a further 40-year extension. In exchange, the UK will pay Mauritius “an annual average of £101 million for 99 years in 2025-26 prices, totalling around £3.4 billion”. Under the deal Mauritius can also allow for the settlement of the islands apart from Diego Garcia.

The UK’s 1966 agreement with the US over Diego Garcia requires the UK to have sovereignty over the islands. Politically, this means the UK government must get the US administration back on side before the deal with Mauritius can be completed. Legally it has been suggested that the treaty complies with international law.

Having anticipated the financial gains from leasing the base back to the UK as part of the treaty, the delay means that the Mauritian government is unable to address its budget deficits or deliver on promises made to the electorate. This is why Mauritius is now exploring legal options to sue the UK over the delay.

How we got here

During the cold war, the US and UK agreed that the UK government would detach the Chagos Archipelago from its then colony of Mauritius to provide a base “for future US and UK military use”. Alongside the detachment, the islands’ population, the Chagossians, were forcibly removed to ensure the security of the base on Diego Garcia. This base enables the US to project military power across Africa, Asia and the Middle East.

In 2019, after a campaign by Mauritius in the UN general assembly, the International Court of Justice found that The UK’s retention of the Chagos islands as a colony was unlawful, and it was obliged to end the colonisation “as rapidly as possible”.

UK ministers responded that they did not consider the decision binding, as it was only an advisory opinion. Nonetheless, because it provides an authoritative statement on the relevant law, the consequences started to bite. In 2021, a special chamber of the International Tribunal for the Law of Sea held that the opinion had legal effect.

In 2022, the Conservative government under Liz Truss began negotiations with Mauritius. Two years later, the two governments agreed to enter into a treaty supported by legislation.

Under the Diego Garcia Military Base and British Indian Ocean Territory bill, sovereignty of the archipelago will be transferred to Mauritius. This includes Diego Garcia. The current UK government regards the deal as the best means of securing the military base, given the weakness of its sovereignty claims.




Read more:
Chagos islands: what the UK-Mauritius agreement means for displaced Chagossians


Many Chagossians opposed the deal on the grounds that they had been insufficiently consulted. This opposition has been highlighted by some of the deal’s detractors in the UK parliament, particularly in the Conservative party. But no UK government has ever taken steps to facilitate resettlement for the Chagossians. This sudden vocal support for their cause is opportunistic.

The high court has also comprehensively rejected a legal challenge to the government’s plans mounted by some Chagossians. The judge assessed multiple claims to be unarguable, not least because the security and foreign relations issues at stake are policy areas where ministers enjoy broad discretion. Notwithstanding plans for an appeal, it would mark a startling change in the courts’ approach to formally recognise the Chagossians as having litigable interests in the islands.

The UK has repeatedly asserted its support for a rules-based international order in the face of wars of aggression and territorial expansion by states such as Russia. It would be acutely embarrassing for it to simultaneously maintain its own territorial claims. This dispute thus determines the extent to which the UK considers its rhetorical commitments to international law to be binding when its own interests are at stake.

The Conversation

Sue Farran has previously received funding from UKRI (UK Research and Innovation) and the British Academy. She is affiliated with RESI (Resilient and Sustainable Islands Initiative)

Colin Murray has previously received funding from UKRI (UK Research and Innovation).

ref. Why the Chagos Islands deal is delayed – and Mauritius is threatening to sue the UK – https://theconversation.com/why-the-chagos-islands-deal-is-delayed-and-mauritius-is-threatening-to-sue-the-uk-278130

Hormone therapy and dementia risk: what a new study says about menopause treatment

Source: The Conversation – UK – By Eef Hogervorst, Professor of Biological Psychology, Loughborough University

Dmytro Zinkevych/Shutterstock

Hormone therapy is widely used to treat menopausal symptoms such as hot flushes and night sweats. But scientists have long debated whether it affects dementia risk.

A new study adds another piece to this puzzle. It suggests that an Alzheimer’s biomarker may help identify which women are more vulnerable to dementia with certain hormone therapies.

Researchers analysed blood samples from 2,766 women recruited into a clinical trial in 1996 to 1999. They then followed participants until 2021 to examine whether levels of plasma p-tau217 at the start of the study were linked to people developing dementia, and whether this relationship differed depending on whether participants had used hormone therapy.

Plasma p-tau217 is a biomarker for Alzheimer’s disease, a measurable biological signal of the condition. Higher levels in the blood are linked to brain changes associated with Alzheimer’s.

Alzheimer brain comparison in axial view showing differences between a healthy and affected brain, with cortical atrophy and neurodegeneration, displayed on a black background
Differences between a healthy and Alzheimer’s affected brain,
VisualMediaHub/Shutterstock

The study compared women who received a placebo or two types of hormone therapy. One was combined hormone therapy containing oestrogen and progesterone, usually prescribed for women who still have their womb. The other was oestrogen-only therapy, typically given after hysterectomy.

Women with higher levels of the Alzheimer’s biomarker had a substantially greater risk of developing dementia. In the study’s main analysis, higher baseline p-tau217 levels were associated with about three times the risk.

However, the relationship differed depending on the type of hormone therapy used. Among women assigned to combined hormone therapy, higher biomarker levels were linked to roughly four times the risk of dementia. This pattern was not seen among women using oestrogen-only therapy.

The association was strongest in certain groups, including women aged over 70, white women and those carrying the APOE4 genotype, a genetic variant that increases a person’s risk of developing Alzheimer’s disease.

Scientists think the difference between therapies may relate to how hormones interact with Alzheimer’s biology. Oestrogen may help protect brain cells and influence how the brain processes amyloid and tau proteins that accumulate in Alzheimer’s disease. Progesterone may modify these effects in ways that are not yet fully understood.

Colleagues and I earlier found that carriers of this genetic risk factor who used hormone therapy also had worse dementia-related biomarkers than those not using hormones or not carrying the genetic risk.

Earlier evidence

Data for the new analysis came from the Women’s Health Initiative studies, a large programme of clinical trials examining the long-term health effects of hormone therapy.

One component of this programme, the Women’s Health Initiative Memory Study, examined whether hormone therapy influenced dementia risk. The 2003 study found that combined hormone therapy roughly doubled the risk of dementia among women aged 65 and older. The wider hormone therapy trial was later stopped earlier than planned because overall risks, including breast cancer, stroke and blood clots, outweighed the benefits.

These findings applied to women who began hormone therapy after age 65. At the time, hormone therapy was often prescribed long-term to prevent conditions such as osteoporosis. Today it is usually started earlier, around menopause, which occurs at about age 50.

After these results were published, many women stopped taking hormone therapy, including those near menopause.

Later research suggested a more nuanced picture. Follow-up analyses of women who started hormone therapy between the ages of 50 and 54 found no evidence that treatment affected cognitive function when assessed six to seven years after the trial ended.

Woman standing by window with hand on heart, looking worried
The 2003 WHIMS study linked combined hormone therapy to dementia risk in women over 65. The findings led many women to stop HRT, even though most begin treatment around menopause.
SpeedKingz/Shutterstock

Similar findings have been reported in other clinical trials of relatively healthy women who began hormone therapy close to menopause. These studies suggest that up to ten years of combined hormone therapy appears generally safe but does not provide measurable cognitive benefits.

The picture looks different when hormone therapy is started later in life.

Different results in older women

Among women who began hormone therapy after age 65 in the Women’s Health Initiative studies, overall cognitive performance declined when tested around age 70. This decline was particularly noticeable in women who already had lower cognitive function at the start of the study.

Further evidence came from a 2010 analysis of the same group of women. Eight years after joining the study, MRI scans showed trends towards smaller volumes in the hippocampus and frontal lobes among older women using combined hormone therapy.

Shrinking in the hippocampus is commonly seen in Alzheimer’s disease and may indicate that combined hormone therapy could worsen existing brain vulnerability in some older women.

New findings

The new analysis adds further evidence and is consistent with meta-analyses by my colleagues and me of national registry data showing increased Alzheimer’s risk in older women using combination hormone therapy but not oestrogen alone. A smaller increase was also seen in women nearer menopause when treatment lasted more than five years.

Menopausal symptoms themselves may also play a role. Severe hot flushes and night sweats have been linked to a higher risk of dementia when they occur later in life. Women with these symptoms are also more likely to use hormone therapy, making the effects of symptoms harder to separate from treatment.

Symptom severity is also associated with other dementia risk factors, including smoking and obesity, poor sleep, and stress and alcohol use.

What does this mean for women?

Importantly, this study does not show that hormone therapy itself causes dementia. Instead, it suggests that biological risk markers may help identify women who could be more vulnerable when treatment begins later in life.

Overall, the relationship between hormone therapy and dementia risk appears to depend on when treatment starts, whether someone already has underlying risk factors, and how long therapy is used.

Starting combined hormone therapy later in life, particularly after age 65, may increase the risk of cognitive decline in some women. But studies have generally not found the same risks when treatment begins around menopause and is used for shorter periods.

Taking hormone therapy for five years or less when started around menopause has not been linked to increased cognitive decline or Alzheimer’s disease in clinical trials or in most national registry studies.

Because most women use hormone therapy for a limited time to manage menopausal symptoms, it is unlikely to increase dementia risk when started around menopause.

The Conversation

Eef Hogervorst receives funding from various funding bodies including RST, ISPF, ARUK, ESRC for her research but this is not directly related to this paper. She acted as expert for hormones and dementia risk for NICE 2024 Guidelines and ESHRE 2016 EU Guidelines

ref. Hormone therapy and dementia risk: what a new study says about menopause treatment – https://theconversation.com/hormone-therapy-and-dementia-risk-what-a-new-study-says-about-menopause-treatment-277987

George Sand et Pierre Leroux, un duo d’entrepreneurs socialistes aux origines de la Scop

Source: The Conversation – France (in French) – By Patrick Gilormini, Economie & Management, ESDES – UCLy (Lyon Catholic University)

Dans le village de Boussac (Creuse) se trouvait une imprimerie qui fit travailler jusqu’à 80 personnes. Le bâtiment est aujourd’hui détruit. Wikimedia commons, CC BY

Cent cinquante ans après sa mort, George Sand reste encore mal connue dans un pan entier de son existence. L’autrice de la Petite Fadette ou de l’Homme de neige fut aussi une militante qui investit dans un projet original d’imprimerie. Son promoteur, le socialiste Pierre Leroux, en fit une des premières coopératives, à rebours du capitalisme moderne. C’est à Boussac, dans la Creuse, que l’utopie prit forme et vie.


Alors que la dermatose nodulaire bovine est le dernier épisode en date de la crise agricole française, avec pour conséquence inattendue une exclusion des bovins du Salon de l’agriculture de Paris en 2026, il convient de relire le regard que pose sur l’économie rurale la romancière George Sand (1804-1876), dont nous célébrons le cent cinquantième anniversaire de la disparition cette année. Inspirée par les idées de Pierre Leroux (1797-1871) en matière d’écologie, elle défend la justice et la solidarité, ancrée dans une foi en l’égalité progressive de l’humanité.

Née à Paris le 1er juillet 1804, c’est au domaine de Nohant-Vic (Indre) que George Sand a vécu l’essentiel de sa vie et qu’elle s’est éteinte le 8 juin 1876, faisant venir autour d’elle les plus grands artistes de son temps (Chopin, Liszt…). Femme de lettres avant-gardiste, elle a abordé des thématiques qui résonnent encore aujourd’hui : la démocratie, le féminisme, l’écologie.

Un soutien essentiel

Une dimension moins connue de l’autrice mérite d’être rappelée. George Sand s’intéressait aux problèmes économiques et sociaux de son époque et s’y investit personnellement. Ainsi, elle soutint la création d’une imprimerie à Boussac (Creuse) par le socialiste Pierre Leroux, qui d’octobre 1845 à février 1848, fait figure à maints égards d’ancêtre lointain des sociétés coopératives contemporaines.




À lire aussi :
Charles Fourier, ce penseur du XIXe siècle qui voyait le travail comme un plaisir


Petit retour en arrière, en novembre 1841. Pierre Leroux vient d’achever avec Jean Reynaud l’Encyclopédie nouvelle et fonde la Revue indépendante avec George Sand et Louis Viardot. L’idée et le nom de la revue viennent du refus de l’éditeur de la Revue des Deux Mondes, François Buloz, de publier en l’état Horace, et veut lui imposer une autocensure. Ce roman de George Sand est jugé socialement trop audacieux de par ses positions de défense du peuple et de critique de la bourgeoisie et des institutions.

Après Horace publié en 1842, la Revue indépendante publiera Consuelo, roman de l’émancipation et de la liberté de George Sand directement inspiré de la pensée de Leroux. De son côté, les premiers articles que ce dernier publia dans la revue sont des reprises très enrichies d’Aux philosophes et De la philosophie et du christianisme.

Difficultés financières pour la presse

La création et les débuts de ce périodique illustrent les difficultés financières inhérentes à l’entreprise journalistique. Lorsque George Sand et Pierre Leroux le fondent, ils ne peuvent se rémunérer et doivent publier à intervalles irréguliers dans l’attente de fonds suffisants. Même si les articles publiés remportent un succès certain, George Sand se désengage de l’aventure à partir de 1843. Elle lui reproche notamment son excès d’idéalisme, son manque d’efficacité pratique, et la fragilité de son organisation. Elle continue cependant de le soutenir en y publiant encore deux textes entre octobre et novembre 1843, Fanchette, lettre de Blaise Bonnin à Claude Germain.

Cette initiative éditoriale trouve rapidement ses limites, George Sand percevant la nécessité de communiquer les faits au niveau local, par le biais d’un journal d’opposition. Ainsi, en 1844 George Sand publie Jeanne en feuilleton dans le Constitutionnel, journal d’opposition libéral, bonapartiste et anticlérical. Elle continue toutefois à aider financièrement Pierre Leroux à installer son imprimerie à Boussac. Dans ce roman, George Sand explore l’égalité morale et sociale entre les êtres, la dignité de la vie rurale, la critique du capitalisme prédateur, la valorisation de la fraternité et de la solidarité. Ces thèmes sont au cœur du socialisme associationniste de Leroux.

Leroux, un saint-simonien qui a pris ses distances

Pour comprendre le projet d’imprimerie à Boussac, il faut revenir sur l’itinéraire de Pierre Leroux. Issu d’un milieu populaire, il devient après des études secondaires philosophe et entrepreneur. Il se trouve à la tête de quatre grands journaux : le Globe, organe du saint-simonisme (1824 1832), la Revue encyclopédique (à partir de 1832), l’Encyclopédie nouvelle (à partir de 1834), la Revue indépendante (1841‑1848).

Ayant participé à l’aventure saint-simonienne de 1830-1831, il fut le premier à pointer le danger du collectivisme. Pour cela, il combattit dans ses entreprises les inégalités de classes, de race et de sexe. Aussi, Leroux ne reste guère plus d’un an à la direction de la Revue indépendante. Le dernier texte qu’il y publia en janvier 1843 « D’une nouvelle typographie » témoigne de la renaissance chez lui (qui fut un temps ouvrier-typographe et correcteur, ndlr) du désir de réaliser la machine à composer, un projet qu’il avait lancé dès 1822 et qui avait échoué. Il obtint un brevet et les fonds d’un financier, mais la tentative échoue une seconde fois. Leroux fit alors le projet de quitter Paris et de fonder une imprimerie.

Il choisit Boussac dans la Creuse, à proximité de Nohant (le « fief » de George Sand), où il séjourna de 1845 à 1848. L’aide financière de George Sand fut la condition de l’entreprise. Une colonie s’organisa qui regroupa jusqu’à 80 personnes autour de Pierre Leroux, de ses trois frères et de leurs familles. La journaliste féministe Pauline Roland (1805-1852) fut responsable de l’école de la communauté. La Revue sociale y fut créée en 1845.

France Culture, 2022.

Imprimerie et agriculture circulaire

Installée dans un ancien hospice, l’imprimerie de Boussac, est une expérience d’envergure qui mobilise un collectif de 80 personnes comprenant la famille, les amis et les disciples de Pierre Leroux. L’imprimerie étant implantée dans une ferme, elle intégrait des travaux agricoles partagés. Des cultures et des animaux de basse cour étaient exploités collectivement dans une esprit d’autosubsistance.

Leroux y met en œuvre les principes qu’il a développés dans son œuvre, notamment le circulus, une vision avant-gardiste de l’économie circulaire, en opposition au paradigme productiviste de l’agriculture, promu par Chaptal, Liebig et la chimie agricole. La communauté de Boussac, en suivant les principes de Leroux, atteindra l’autosuffisance alimentaire.

Par ailleurs, Leroux met au point le « pianotype », un nouveau procédé de composition typographique. Cette entreprise n’est pas seulement un journal ; elle est l’expression d’une communion dans la religion de l’humanité se fondant sur l’unité de l’expérience humaine, une religion d’inspiration saint-simonienne, qui s’étend de Boussac à Paris, jusqu’à Limoges et d’autres villes, et relie entre eux tous les disciples de sa « Doctrine de l’humanité ».

Tous les participants à la coopérative recevaient un salaire égal et tous les bénéfices étaient réinvestis dans l’entreprise. Dans les années 1995 à 2000, on y verra les prémices des sociétés coopératives et participatives (Scop) et d’une économie sociale et solidaire pour qui, face à la crise des solidarités abstraites, l’émergence de nouvelles solidarités concrètes de ce type permet de ne pas revenir à des solidarités « héritées ».

La révolution de 1848 sonnera le glas de cette communauté. Pierre Leroux devient maire de Boussac, puis député de la Seine et quitte la Creuse. Quant à George Sand, elle a géré sa carrière de manière très professionnelle et ne s’est pas contentée de vivre de ses rentes. Elle a été également une entrepreneuse, créatrice et directrice de journaux, qui prenait des risques. Tout en entretenant son image de marque personnelle, elle a financé et encouragé l’entreprise communautaire de Pierre Leroux qui aurait difficilement existé sans son soutien.

The Conversation

Patrick Gilormini est membre de la CFDT.

ref. George Sand et Pierre Leroux, un duo d’entrepreneurs socialistes aux origines de la Scop – https://theconversation.com/george-sand-et-pierre-leroux-un-duo-dentrepreneurs-socialistes-aux-origines-de-la-scop-275050

Quand la peste a décimé la population mondiale, la biodiversité a, paradoxalement, elle aussi chuté

Source: The Conversation – France (in French) – By Christopher Lyon, Visiting Research Fellow, Centre for Death and Society, University of Bath

L’effondrement de la population après la peste noire s’est accompagné d’un recul marqué de la biodiversité végétale, suggérant que les paysages agricoles traditionnels contribuaient à maintenir une grande diversité de plantes. Paul Nash/Shutterstock

On imagine souvent qu’une nature débarrassée des humains se porterait mieux. Mais une nouvelle étude sur la peste noire montre l’inverse : lorsque la population européenne s’est effondrée au XIVᵉ siècle, la diversité des plantes a elle aussi chuté.


Entre 1347 et 1353, l’Europe a été frappée par la pandémie la plus catastrophique de son histoire : la peste noire. En faisant des dizaines de millions de morts, l’épidémie a anéanti entre un tiers et la moitié de la population européenne.

Dans certaines villes, les taux de mortalité ont atteint 80 %. Dans les campagnes, la mortalité liée à la peste noire a provoqué de graves pénuries de main-d’œuvre. Des villages entiers se sont vidés alors que les économies rurales se sont effondrées. Dans de nombreuses régions, les champs cultivés ont été abandonnés et progressivement reconquis par les forêts, les broussailles et les cerfs.

Compte tenu des effets négatifs que les humains ont eus sur la nature au cours des dernières décennies et des derniers siècles, on pourrait s’attendre à ce que ce « réensauvagement » à l’échelle du continent ait permis à la biodiversité de prospérer. Pourtant, notre nouvelle étude publiée dans la revue Ecology Letters met en évidence un résultat potentiellement contre-intuitif : lorsque la population humaine de l’Europe s’est effondrée, la biodiversité végétale a elle aussi fortement reculé.

Les grains de pollen fossilisés présents dans les carottes de sédiments extraites des lacs et des tourbières contiennent des informations sur les communautés végétales qui existaient il y a des milliers d’années. Nous avons utilisé les données de plus de 100 archives de pollen fossile provenant de toute l’Europe pour déterminer comment la diversité des plantes a évolué avant, pendant et après la peste noire.

Les données polliniques montrent qu’entre l’an 0 et 1300, la diversité végétale en Europe a augmenté. Elle a progressé tandis que l’Empire romain d’Occident connaissait son plein essor puis son déclin et a continué de croître durant le haut Moyen Âge. Au Moyen Âge dit « central », les niveaux de biodiversité avaient atteint leur maximum.

Cependant, en 1348, la peste frappe l’Europe et, pendant environ 150 ans, la biodiversité végétale s’effondre. Ce n’est qu’après un siècle et demi – lorsque les populations humaines se reconstituent et que l’agriculture reprend – que la diversité des plantes commence à augmenter de nouveau.

La peste à Florence en 1348, telle que décrite dans le Décaméron de Boccace. Gravure de L. Sabatelli.
Wellcome Collection gallery (2018-04-05), CC BY-NC-ND

Nous avons constaté que les pertes les plus importantes de diversité végétale se produisaient dans les zones les plus touchées par l’abandon des terres. En comparant l’évolution de la biodiversité sur des sites ayant connu des trajectoires différentes d’usage des terres après la peste noire, nous avons observé que la biodiversité s’est effondrée dans les paysages où les cultures (terres arables) ont été abandonnées, tandis que les paysages où l’agriculture arable progressait ou restait stable devenaient plus riches en biodiversité.

Nos travaux suggèrent que plus de 2 000 ans d’augmentation de la biodiversité en Europe ont été générés grâce aux humains – et non malgré eux. Mais pourquoi ? Et quelles leçons pouvons-nous en tirer pour la gestion actuelle de la biodiversité, alors même que la conversion des terres en surfaces agricoles entraîne aujourd’hui des pertes de biodiversité ?

La croissance de la population et les innovations technologiques ont poussé les activités agricoles vers des terres jusque-là inexploitées au cours des 1 300 premières années de notre ère. Contrairement à aujourd’hui – où les monocultures dominent – les systèmes agricoles mixtes étaient la norme pendant la majeure partie des 2 000 dernières années.

À travers l’Europe, une mosaïque variée de terres agricoles et de pratiques agricoles était généralement entrecoupée de bois, de pâturages extensifs et de parcelles non cultivées, souvent délimitées par des haies ou des arbres.

Il en résultait un paysage morcelé offrant de multiples niches où différentes espèces végétales pouvaient se maintenir, et où la biodiversité était élevée.

La peste noire a rompu cet équilibre en réduisant les perturbations liées aux activités humaines. Le paysage est alors devenu moins hétérogène et la diversité végétale a globalement décliné. Celle-ci n’a commencé à se rétablir qu’avec le retour d’une agriculture extensive.

Les humains peuvent aussi favoriser la nature

Ces résultats remettent en question les politiques de conservation qui prônent la suppression ou la réduction de l’influence humaine sur les paysages européens afin de protéger la biodiversité.

L’une de ces initiatives est le réensauvagement, que beaucoup considèrent comme une voie vers un avenir riche en biodiversité, où la nature disposerait de l’espace nécessaire pour prospérer. Pourtant, nombre des zones les plus riches en biodiversité en Europe sont celles qui possèdent une longue histoire d’agriculture mixte et de faible intensité. Réensauvager ces paysages façonnés par l’activité humaine pourrait, paradoxalement, éroder la biodiversité que les politiques de conservation cherchent précisément à protéger.

Nos résultats montrant une relation positive de long terme entre humains et biodiversité ne se limitent pas à l’Europe. Des interactions multimillénaires entre les sociétés humaines et le monde naturel ont conduit à des niveaux élevés de biodiversité dans de nombreuses régions de la planète. Parmi ces écosystèmes culturels riches en diversité figurent les jardins forestiers du nord-ouest du Pacifique (des forêts cultivées par les peuples autochtones), les satoyama du Japon (des systèmes mixtes de rizières et de boisements dans les piémonts montagneux) ou encore les ahupuaʻa d’Hawaï (des portions de versants où l’on cultive une grande variété de plantes).

Les pratiques agricoles modernes et intensives ont entraîné d’importantes pertes de biodiversité à l’échelle mondiale. Pourtant, les résultats tirés de notre étude sur la peste noire, combinés à de nombreux autres exemples, montrent que humains et nature n’ont pas toujours besoin d’être séparés pour conserver et favoriser la biodiversité. Reconnaître les paysages comme des écosystèmes culturels peut au contraire nous aider à imaginer des futurs où la nature et les sociétés humaines peuvent coexister et prospérer.

Les pratiques agricoles modernes et intensives ont entraîné d’importantes pertes de biodiversité à l’échelle mondiale. Pourtant, les résultats tirés de notre étude sur la peste noire, combinés à de nombreux autres exemples, montrent que humains et nature n’ont pas toujours besoin d’être séparés pour conserver et favoriser la biodiversité. Reconnaître les paysages comme des écosystèmes culturels peut au contraire nous aider à imaginer des futurs où la nature et les sociétés humaines peuvent coexister et prospérer.

Pendant des millénaires, des modes traditionnels de gestion des terres à faible intensité ont façonné des écosystèmes diversifiés. Aujourd’hui, lorsque le contexte local s’y prête, ils devraient être encouragés afin de préserver à la fois la diversité biologique et la diversité culturelle.

The Conversation

Christopher Lyon reçoit des financements d’un centre de recherche du Leverhulme Trust — le Leverhulme Centre for Anthropocene Biodiversity, subvention n° RC-2018-021 — ainsi que du Biotechnology and Biological Sciences Research Council, subvention n° BB/Z516697/1. Il a également bénéficié par le passé de financements du York Environmental Sustainability Institute, du White Rose University Consortium, du Biotechnology and Biological Science Research Council, de l’Economic and Social Research Council, du Natural Environment Research Council et du gouvernement écossais (subvention n° BB/R005842/1), ainsi que du Social Sciences and Humanities Research Council du Canada (subvention n° 132726).

Jonathan D. Gordon reçoit des financements d’un centre de recherche du Leverhulme Trust — le Leverhulme Centre for Anthropocene Biodiversity, subvention n° RC-2018-021.

ref. Quand la peste a décimé la population mondiale, la biodiversité a, paradoxalement, elle aussi chuté – https://theconversation.com/quand-la-peste-a-decime-la-population-mondiale-la-biodiversite-a-paradoxalement-elle-aussi-chute-277869

The nine worst mothers in literature – according to our experts

Source: The Conversation – UK – By Alison Taft, Course Director of Creative Writing, Leeds Beckett University

For Mother’s Day, we asked nine of our academic experts to tell us who they think is the worst mother in literature. From serious villains to children’s book baddies, these mothers subvert every maternal instinct.

1. Mummy, Eleanor Oliphant is Completely Fine by Gail Honeyman (2017)

Isolated, broken and wedded to routine, 30-year-old Eleanor avoids mirrors, not due to the physical scars she bears, but because she sees “too much of Mummy’s face there”.

Readers meet “Mummy” only through her weekly conversations with Eleanor, but as a critical voice she is unsurpassed: “You’re not smart, Eleanor. You’re someone who lets people down. Someone who can’t be trusted. Someone who failed.” We soon learn there are no depths to which this mother hasn’t sunk.

The novel serves as a stark reminder that a mother’s reach goes far beyond childhood. “The two of us are linked forever, you see – same blood in my veins that’s running through yours. You grew inside me, your teeth and your tongue and your cervix are all made from my cells, my genes.”

The novel’s message – that recovering from an experience so embodied is possible – offers hope to all those with less than ideal mothers.

Alison Taft is a senior lecturer in creative writing

2. Edith Stoner, Stoner by John Williams (1965)

Stoner was the first novel that gave me a book hangover with its devastating family dynamics and tragic ending. Edith is a chilling example of maternal dysfunction. I only realised in later readings that her emotionally repressed upbringing and potential abuse result in her perpetuating familial dysfunction.

Edith is initially indifferent and cold towards her daughter Grace, but her interest awakens when a bond develops between Grace and her husband. Grace then becomes a weapon: Edith systematically isolates the girl from her father by controlling her time and manipulating her affections. Over time, she manages to place a wedge between them.

Grace eventually grows into a struggling young woman. She’s an alcoholic and escapes her troubled home when she accidentally falls pregnant and marries. She becomes a distant, unavailable mother herself. The novel’s engagement with trauma cycles left me feeling heartbroken for days.

Christina Hennemann is a PhD candidate in English

3. Arabella Don, Jude the Obscure by Thomas Hardy (1895)

The conniving Arabella Donn from Thomas Hardy’s Jude the Obscure illustrates the uncomfortable truth that being a bad mother can sometimes be essential for self preservation.

Hardy shows Arabella bathed in blood as she cheerfully slaughters a long-suffering pig, signalling her pragmatic refusal of feminine sentimentality. She approaches marriage, pregnancy and motherhood with similarly callous logic; as strategies for survival in a world offering women woefully little security. Arabella initially fakes pregnancy to trap Jude, and then blithely abandons her son when he proves inconvenient.

By conventional standards, Arabella’s maternity appears monstrous. Yet Hardy’s portrayal reflects a far more monstrous reality; selfless maternity is a dangerous liability in a society that neither protects women nor meaningfully supports motherhood. Arabella survives precisely because she is an appalling mother. Yet if we were to cast blame for her maternal failures, it lies less with Arabella than with the social conditions that make motherhood such a profoundly vulnerable predicament.

Angela Dunstan is a reader in English literature and visual culture

4. Samira, The Beginning and the End by Naguib Mahfouz (1949)

Egyptian Nobel laureate Naguib Mahfouz’s novel The Beginning and the End presents widowed mother Samira as a figure often praised for her strength and virtue. After losing her husband, she takes on the challenge of holding together a family reduced to poverty. She is strict and disciplined and expects her four children to sacrifice for one another.

For me, however, she is a deeply flawed mother. Like other neglectful maternal figures in Mahfouz’s work, she cloaks her selfishness and emotional blindness in the language of duty and sacrifice.

Nefisa, the plain member of the family, is pushed into making sacrifices for her brothers. Samira directs all her concern and ambition toward her sons, while remaining blind to her daughter’s needs.

Nefisa becomes a seamstress, starved of love and deprived of any prospect of marriage. Left unprotected, she encounters unsavoury characters on her way to and from work, and eventually becomes a sex worker.

Samira may seem a paragon of virtue, but her rigid morality and refusal to see her daughter’s suffering make her complicit in Nefisa’s tragic end.

Wen-chin Ouyang is a professor of Arabic and comparative literature

5. Mrs Wormwood, Matilda by Roald Dahl (1988)

Before “phubbing” – snubbing your child in favour of interacting with your phone – there was Mrs Wormwood, the mother of Roald Dahl’s Matilda.

Wormwood is in thrall to TV shows and TV dinners, looks not books. She is uninterested in her preschooler’s safety, let alone pastimes. While she plays bingo on weekday afternoons, four-year-old Matilda walks across town to the public library.

Mrs Phelps, a kindly librarian, is the first of two substitute mothers. She watches over Matilda while she reads, with concern but without interference, guiding her reading only when asked. Miss Honey – a mild, quiet and exceptionally empathetic teacher – stretches her clever little charge, while teaching the rest of the juniors to read.

When Matilda’s equally awful father gives her half-an-hour to pack for a permanent move to Spain, she arranges to be adopted by Miss Honey – with her mother’s blessing: “It’ll be one less to look after.”

Sarah Olive is a senior lecturer in English literature

6. Adora Crellin, Sharp Objects by Gillian Flynn (2006)

The struggle for maternal perfection turns monstrous in Gillian Flynn’s novel Sharp Objects.

Adora, matriarch of the Crellin family, has Munchausen by Proxy Syndrome, a psychological disorder where, as the book explains: “The caregiver, usually the mother, almost always the mother, makes her child ill to get attention for herself.”

Adora is monstrous because she takes the cultural ideal of the devoted mother too far. She harms her children so that they must blindly accept her medicines and perverse care, telling them it is only then that she will love them forever. For rejecting Adora’s toxic remedies, her daughter Camille is emotionally neglected.

Both girls act out against this suffocating mothering through risky sexual behaviour, self-harm and crime. Flynn’s portrayal of Adora as the “perfect mother” undercuts the ideal that motherhood is a natural role for all women.

Ailish Brassil is a PhD candidate in English literature

7. The ‘new’ Bobbie, The Stepford Wives by Ira Levin (1972)

In the suburb of Stepford, Connecticut, local women’s husbands conspire to murder their wives and replace them with compliant robot duplicates. Bobbie Markowe becomes one such replaced woman.

The “new” Bobbie’s children appear happy with their changed mother who “doesn’t shout any more” and “makes hot breakfasts”. But the Stepford wives are not built for the complex demands of motherhood. These wife replacement robots are designed by their husbands to please and appease them, and this treatment is extended by Bobbie to her sons.

Although not as obviously harmful as physical or verbal abuse, this dynamic of constant indulgence warps the children’s understanding of mothers and of women in general. And despite her supposed gentleness, in “new” Bobbie’s garden the family dogs have been chained up – an ominous warning to any dependants who become too messy or inconvenient.

Faye Lynch is a PhD candidate in English literature

8. Tamora, Titus Andronicus by William Shakespeare (circa 1558)

There are few mothers in Shakespeare’s dramas, but Tamora in Titus Andronicus is one of the most memorable – for all the wrong reasons.

Tamora seeks revenge for the death of her eldest son at the hands of Titus. She is cunning and ruthless, scheming to wreak bloody havoc on Titus and his family. But this is Shakespeare’s take on ancient Rome, where might and masculinity rule, so violence breeds violence and the war hero Titus gets the last word.

In retaliation for Tamora’s crimes, Titus kills her wicked sons and, in the tragedy’s spectacular finale, serves them up to her baked in a pie. After this, Rome’s new emperor symbolically marks the regime change by expelling Tamora’s corpse from the city. Though Tamora has some maternal virtues – she is fiercely loyal at least – her vindictiveness, power and lust mean that she is destined for an unforgettable Shakespearean death.

Edel Semple is a senior lecturer in Shakespeare studies

9. Undine Spragg, The Custom of the Country by Edith Wharton (1913)

Undine Spragg is a strong candidate for the worst mother in literature. Ruthless, ignorant and narcissistic, this anti-heroine marries four times in a self-absorbed project of social climbing and celebrity seeking.

When her son Paul is born, Undine’s reaction is so unimportant that it is missing from the novel. When he’s a toddler, she forgets about his birthday because she is at a party (although Paul’s father also fails to turn up on time).

The final chapter of the novel opens on a description of the timid and tender nine-year-old Paul wandering alone through her latest residence. Undine’s lack of maternal feeling stands as an example of ultra-rich folly that has long thrilled and horrified Wharton’s largely middle-class readership.

Stephanie Palmer is a senior lecturer in English literature

Who do you think is the worst mother in literature? Let us know in the comments below.

This article features references to books that have been included for editorial reasons, and may contain links to bookshop.org. If you click on one of the links and go on to buy something from bookshop.org The Conversation UK may earn a commission.

The Conversation

The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

ref. The nine worst mothers in literature – according to our experts – https://theconversation.com/the-nine-worst-mothers-in-literature-according-to-our-experts-275252

Jesse Jackson’s misdiagnosis of Parkinson’s is common – new genetic discovery could lead to treatment for this deadly disease

Source: The Conversation – USA – By Jose Abisambra, Professor of Neuroscience, University of Florida

Rev. Jesse Jackson died at age 84 after living with progressive supranuclear palsy. AP Photo/Erin Hooley

“Yes, doctor. My dad’s first fall was on his 65th birthday. He stood in the driveway and suddenly dropped backwards on his back. After he fell two more times, we came to the clinic.”

The symptoms the patient’s son described didn’t fit the usual diagnosis of Parkinson’s disease. The family noted mood changes, including outbursts of anger. When the patient tried reading, the words “jumped” at him. Instead of looking down the page with his eyes, he moved his entire head. While his hands didn’t shake, he noticeably moved around more slowly.

Dad was diagnosed with Parkinson’s. The doctors weren’t convinced this was the right diagnosis, but it was the best they could come up with. He was given medications for Parkinson’s. They treated his symptoms with physical therapy and blood thinners to prevent clots if he got injured from a fall. But his condition worsened, and he died within 10 years.

He had been misdiagnosed. He actually had progressive supranuclear palsy, a rare and aggressive neurodegenerative disease with similar symptoms to Parkinson’s. The late Rev. Jesse Jackson, who died on Feb. 17, 2026, at age 84, had a similar experience of misdiagnosis.

About 6 to 10 in 100,000 people are affected by progressive supranuclear palsy, totaling around 30,000 patients in the United States. But because this disease is often misdiagnosed, the real numbers are likely higher. It shares similar symptoms with Parkinson’s, making it very challenging to distinguish between the two. In fact, PSP is also called atypical parkinsonism. Moreover, the brain cells of people with PSP share similar pathological signs with 20 other neurodegenerative disorders.

Progressive supranuclear palsy significantly reduces a person’s ability to function.

There are no biological tests to screen for progressive supranuclear palsy and no therapies specifically for this disease. Patients like Jackson are stuck with treatments that don’t improve their quality of life. In our recently published research, my neuroscience lab identified a potential biomarker that could help change how doctors approach this disease.

Genetics of progressive supranuclear palsy

Rare genetic changes can increase someone’s risk of developing progressive supranuclear palsy.

For example, researchers found that a single mutation on the gene coding for the stress sensor protein PERK increases a person’s risk of developing the disease. PERK helps relieve stress from a part of the cell that acts as a warehouse for newly made proteins. When the cell becomes stressed, PERK dials down the production of new proteins and gives this warehouse time to recover.

Many labs worked to find why this single change in DNA could unleash a devastating life sentence. My team and I had previously found that alterations in a key protein involved in neurodegenerative diseases, tau, can activate PERK, which further weaponizes abnormal tau against cells.

3D model of a cluster of green spirals and ribbons, a clump of yellow spheres near the center
PERK protein.
A2-33/Wikimedia Commons, CC BY-SA

After identifying three other PERK mutations, the field focused on targeting PERK as a way to treat the disease. However, results were conflicting: Both increasing and decreasing PERK activity improved cell survival and brain function in animal and cell models.

Then researchers made a crucial discovery: Unlike properly functioning PERK, the mutant form of this protein could not eliminate tau clumps in the brain. This meant that the brain normally has a way to get rid of toxic tau, but this mechanism was compromised in people who have the mutation.

Treatment strategies that could change the activity of PERK, even in sick patients, could provide a way to fight this disease.

How PERK connects to PSP

My team and I wanted to understand how PERK promotes the abnormal accumulations of tau protein that causes progressive supranuclear palsy.

First, we genetically engineered cells to express normal or mutant PERK. As expected, while both forms of PERK carried out nearly identical functions, mutant PERK did not sufficiently clear out tau. Our next step was to identify which proteins PERK actually affected.

We hypothesized that both versions of PERK reduced the production of different proteins. To test this, we tagged cells with an antibiotic that attaches to newly made proteins.

Surprisingly, only four proteins differed between normal and mutant PERK cells, suggesting we’d found a potential key to understand how progressive supranuclear palsy develops and how it kills brain cells.

One of the proteins we identified, DLX1, was previously associated with the disease. After confirming that DLX1 is enriched in the brains of people with PSP, we tested how changing DLX1 levels would affect fruit flies engineered to produce high levels of tau in their brains.

We found that reducing DLX1 levels in the flies minimized the damage tau causes on cells. These findings strongly imply that DLX1 plays a role in the development of progressive supranuclear palsy.

Future of PSP treatment

Effectively treating diseases requires identifying how they damage cells at the molecular level. Early diagnosis is especially critical to opening an effective therapeutic window before irreversible damage occurs.

Our study offers the first evidence linking key proteins involved in the development of progressive supranuclear palsy, which has major implications for how it’s treated and diagnosed. For example, screening for higher DLX1 levels in the brain or blood could confirm a diagnosis of the disease. Also, developing drugs that reduce DLX1 could potentially reduce symptoms in patients.

Importantly, our team identified three other proteins we are currently testing to see whether they can also offer improved diagnostic and therapeutic value. Combination therapies that target these proteins could potentially help improve patients’ lives.

As researchers work toward more accurate diagnoses and treatment, patients can have more hope to alleviate the devastating consequences of progressive supranuclear palsy.

The Conversation

Jose Abisambra receives funding from the National Institutes of Health. Prior research funding for his work originated from the Department of Defense, the Alzheimer’s Association, the Rotary Club, and the CurePSP foundation. He is a consultant for CurieBio and co-editor-in-chief of the scientific journal Brain Research.

ref. Jesse Jackson’s misdiagnosis of Parkinson’s is common – new genetic discovery could lead to treatment for this deadly disease – https://theconversation.com/jesse-jacksons-misdiagnosis-of-parkinsons-is-common-new-genetic-discovery-could-lead-to-treatment-for-this-deadly-disease-276944

While the US government is investigating unidentified anomalous phenomena, academic researchers studying them face stigma

Source: The Conversation – USA – By Darrell Evans, Professor of Environmental Science and Sustainability, Purdue University

A famous UAP video shows an unexplained object as it soars high along the clouds, traveling against the wind. Department of Defense via AP

President Donald Trump directed the Pentagon and other federal agencies to begin releasing government files related to UFOs and unidentified anomalous phenomena – called UAP – in February 2026, following years of pressure from Congress, military whistleblowers and the public.

Congress formally mandated UAP investigations through the National Defense Authorization Act in December 2022. The Pentagon’s official UAP investigative body, the All-domain Anomaly Resolution Office, AARO, now carries a caseload exceeding 2,000 reports dating back to 1945. Defense Secretary Pete Hegseth confirmed this figure earlier this year.

The cases were submitted by military personnel, pilots and government employees describing aerial objects that could not be explained as known aircraft, drones or weather phenomena. Governments in Japan, France, Brazil and Canada also have their own formal UAP investigation programs.

An open door with a paper sign reading 'UAP (UFO) conference.' Inside is a group of people looking at a screen showing a woman talking.
Filmmaker James Fox organized a press conference on UAP and UFO encounters, held at the National Press Club on Jan. 20, 2026, in Washington, D.C. It focused on a 1996 suspected UFO crash in Brazil.
Kevin Dietsch/Getty Images

Yet modern research universities remain almost entirely absent from this conversation. No major university has established a dedicated UAP research center. No federal science agency offers competitive grants for UAP inquiry. No doctoral programs train researchers in UAP methodology. The gap between what governments openly acknowledge and what universities are willing to study is, at this point, difficult to explain on purely intellectual grounds.

I have navigated this gap while conducting my own UAP research. My work developing the temporal aerospace correlation tool, a standardized framework for correlating civilian UAP sighting reports with documented rocket launch activity from Cape Canaveral, is currently under peer review at Limina: The Journal of UAP Studies.

Designing that framework meant making methodological decisions without community standards, without institutional funding and without the professional infrastructure many researchers in established fields take for granted. What is missing is not interest or data – it is the shared scaffolding that turns isolated curiosity into cumulative science.

Stigma is measurable

The most rigorous evidence for the gap between faculty interest in UAP and faculty willingness to study it UAP comes from peer-reviewed studies by Marissa Yingling, Charlton Yingling and Bethany Bell, published in the scholarly journal Humanities and Social Sciences Communications.

Across 14 disciplines at 144 major U.S. research universities, 1,460 faculty responded to their 2023 national survey. Most surveyed believed UAP research was important. Curiosity outweighed skepticism in every discipline that was part of the study. Nearly one-fifth had personally observed something aerial they could not identify. Yet fewer than 1% had ever conducted UAP-related research.

The gap was not explained by intellectual dismissal, but it was in part explained by fear. Researchers were not primarily deterred by intellectual skepticism because they doubted the topic’s merits. Instead, they feared they might lose funding, face ridicule from colleagues or find their careers quietly derailed. Faculty reported being told to “be careful.”

A 2024 follow-up study found that roughly 28% said they might vote against a colleague’s tenure case for conducting UAP research, even when they personally believed the topic warranted study.

Historian and philosopher of science Thomas Kuhn argued that scientific communities suppress anomalous questions not because those questions are unanswerable, but because they fall outside the boundaries the community has collectively decided are worth investigating.

Sociologist Thomas Gieryn called this suppression “boundary work,” referring to the active process by which scientists police what counts as legitimate science.

For UAP researchers, the data and tools to study the phenomenon exist. What may not exist is social permission to use them without professional consequence.

Creating an academic discipline

Academic disciplines do not emerge spontaneously. They require dedicated journals, agreed-upon methods, graduate programs and professional societies.

The history of cognitive neuroscience demonstrates how disciplines emerge. Before the 1980s, researchers at the intersection of neuroscience and cognitive psychology faced resistance from both parent disciplines.

These fields achieved mainstream acceptance only after targeted funding from the Alfred P. Sloan Foundation, new brain-imaging tools and the gradual formation of academic programs that created career pathways for researchers. Researchers at the nexus of these fields did not wait for central questions to be resolved. They built infrastructure, and the infrastructure made progress possible.

UAP studies as a discipline is developing some of these elements, but largely outside universities. The Society for UAP Studies, a nonprofit of scholars and researchers, operates Limina as a double-blind, peer-reviewed journal and has convened international symposia drawing researchers from physics, philosophy of science and the social sciences. But a nonprofit scholarly society without tenured faculty does not constitute a discipline.

A group of four people working together -- two are standing at a whiteboard.
New academic disciplines are built on research collaborations. Stigma around a topic can stop researchers from sharing their ideas.
fizkes/iStock via Getty Images

To turn UAP studies into a recognized academic field would require three things.

First, funding. The Yingling studies found that competitive research grants would do more to unlock faculty participation than any other single factor. Without grants, researchers cannot hire students to assist them, maintain instruments or sustain the multiyear projects that produce meaningful results.

Second, shared methodological standards – these would entail agreed-upon procedures for collecting, recording and evaluating UAP reports – would mean findings from one research group can be compared and built upon by others.

Third, institutions could publicly affirm that they will evaluate appropriately rigorous UAP scholarship on its scientific merits during tenure reviews. Several universities have already done this for gun violence research and psychedelic-assisted therapy studies.

These are not isolated examples. Research into near-death experiences and adverse childhood experiences followed similar trajectories, moving from being a professional liability to mainstream legitimacy after the removal of institutional barriers.

The international comparison

This gap in UAP scholarship is unique to the United States. France’s GEIPAN, a dedicated investigation unit within its national space agency, has operated since 1977. It has publicly archived approximately 5,300 French UAP cases, of which about 2% to 3% remain unexplained after rigorous analysis.

In 2020, Japan formalized UAP reporting protocols for its Self-Defense Forces, the branch of the Japanese military responsible for national defense. By June 2024, more than 80 lawmakers had formed a parliamentary UAP investigation group that by May 2025 had formally proposed a dedicated UAP research office to the defense minister. Canada launched its own multiagency UAP investigation survey in 2023.

None of these actions has produced a corresponding response from American research universities. Universities provide independent, peer-reviewed analyses that government programs structurally cannot.

The University of Würzburg in Germany became the first Western university to officially recognize UAP as a legitimate object of academic research in 2022, when it formally added UAP investigation to its research canon. Researchers at Stockholm University and the Nordic Institute for Theoretical Physics in Sweden have been actively publishing peer-reviewed UAP research since 2017, most recently in Scientific Reports in October 2025.

Congress has passed legislation, the Pentagon is reporting on its investigations, and the president has directed federal agencies to begin releasing records. So the question no longer is whether governments take UAP seriously – it is whether universities will follow, and which ones will get there first.

The Conversation

Darrell Evans does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. While the US government is investigating unidentified anomalous phenomena, academic researchers studying them face stigma – https://theconversation.com/while-the-us-government-is-investigating-unidentified-anomalous-phenomena-academic-researchers-studying-them-face-stigma-277722

Nearly 1 in 3 missing children in the US are Black, driving Pennsylvania and other states to propose ‘Ebony Alerts’ to ensure equal protection and public safety

Source: The Conversation – USA – By Itay Ravid, Associate Professor of Law, Villanova University

A disproportionate number of Black and Indigenous children go missing in the United States. Catherine McQueen/Moment Collection via Getty Images

Nearly one-third of U.S. children reported missing are Black, even though Black people constitute roughly 14% of the U.S. population.

To address one dimension of this problem, Pennsylvania and a few other states, including Alabama and Massachusetts, have in recent years proposed legislation to reform missing child alert systems. Not all missing children cases trigger an Amber Alert – the nationwide emergency alert system for missing children – but those that do receive greater public and media attention. These states suggest implementing an “Ebony Alert” that focuses on children of color.

Pennsylvania state Rep. Gina Curry introduced a bill “specifically tailored to finding missing Black and Brown youth” in June 2024 and reintroduced it in January 2025. It is currently sitting in the Children and Youth Committee.

Pennsylvania and the other states where these laws are pending are taking a cue from California, which started its statewide Ebony Alert program in January 2024. California’s system aims to guarantee that cases of missing Black youth are treated fairly by law enforcement agencies and the public is alerted in similar fashion and through the same venues offered under Amber Alerts.

I am a law professor who studies victimization and inequalities in the criminal legal system. In a recent legal paper, attorney Tanisha Brown and I examined how Ebony-like laws might save more Black children who go missing.

Our study focuses specifically on Black children, though we recognize that the disproportionate number of missing children from Native American and other marginalized communities also deserve attention and further inquiry.

The crisis of missing Black children

Our original data analysis suggests that the probability of Black children going missing is three times that of white children.

The May 2025 Minority and Missing Report – a collaborative effort among leading law enforcement and various civil society groups – also highlighted the disproportionate number of missing Black, American Indian and Alaska Native children.

These disparities extend beyond reporting rates for missing children.

Black children are also more vulnerable to trafficking and exploitation than white children. Structural inequalities, such as poverty, housing instability and overrepresentation in the foster care system, compound their risks.

Amber’s role in the disparities

The Amber Alert system was adopted in the early 2000s. Amber stands for America’s Missing: Broadcast Emergency Response. It is a powerful and comprehensive alert infrastructure that distributes information about a missing child through radio, television, text messages, highway signs, email notifications and major online platforms, including Google and Facebook.

A digital sign with lights that spell out 'Amber Alert Call 511 for Info'
Amber Alerts inform the public about abducted children.
Darwin Brandis/iStock via Getty Images Plus

Many of the kids who go missing are victims of crime – abducted from their neighborhoods, homes and schools, subjected to physical and psychological abuse, and, in some tragic cases, killed. Amber Alerts mobilize communities to assist in the search process.

To issue an Amber Alert, law enforcement must determine that specific statutory conditions are met, including the age of the child, law enforcement’s belief in imminent danger of serious injury or death, and the sufficiency of existing information to assist in recovery. Crucially, children who are categorized as “runaways” are excluded from Amber eligibility.

Advocacy groups for missing children argue that for a host of reasons, including implicit and explicit racial bias, Black children who go missing are disproportionately labeled as runaways. This excludes them from the protections of the Amber system and reduces the likelihood of them being found.

Even when an Amber Alert is initiated, some data suggests that Black children are less likely to be recovered than white children.

States respond with Ebony Alerts

California’s Ebony Alert system ensures that all cases involving missing Black youth receive public notification comparable in scope and visibility to Amber Alerts. It offers different criteria for the initiation of the alerts. For example, an Ebony Alert may be issued when law enforcement determines that an individual went missing under “unexplained and suspicious circumstances.”

The Pennsylvania proposal generally follows California’s provisions, while stating that it is intended for “young people of color.”

These efforts publicly acknowledge and attempt to address the disproportionate impact of missing-child crises on Black communities. They also shine light on the limitations of formally colorblind frameworks like Amber, as Amber’s race-neutral design has, in practice, produced racially disparate outcomes – with potential life-or-death consequences.

Addressing Amber’s structural flaws

In order to fix the Amber Alert system in states without Ebony Alert legislation, we propose three reforms that would reduce flaws in its design.

1. A more holistic evaluation of missing child cases: Currently, all Amber factors must be present to initiate an alert. Our approach suggests that no single factor should stop an alert from being issued. Doing so will require law enforcement agents to approach each case with more complexity and nuance, including recognizing particular community needs.

2. A broader spectrum of “at risk” conditions: Law enforcement can issue alerts in cases beyond the most typical cases of “serious risk to bodily integrity or death.” This might include “unexplained and suspicious circumstances” or recognizing that the missing person might be subject to trafficking.

3. Shift the burden within law enforcement decision-making: To mitigate bias in alert initiation, we propose that law enforcement bear the burden of explaining why not to initiate an alert – instead of why to – when they cannot explain circumstances behind a child going missing.

Together, these reforms could significantly address existing problems within the Amber system itself.

Equal protection challenges

The design of Ebony Alert laws, however, raises a constitutional question: Can such laws withstand equal protection challenges?

Under current doctrine, Ebony Alert laws would likely be considered a racial classification subject to strict scrutiny, an almost impassable legal hurdle. The 2020 Students for Fair Admissions Inc. v. President and Fellows of Harvard College, in which the Supreme Court ruled that several race-conscious admission programs at Harvard and the University of North Carolina violated the equal protection clause, might have further challenged this type of legislation.

To pass strict scrutiny, laws must be narrowly tailored interventions that serve a compelling state interest.

As Brown and I argue, the interests and context of Ebony Alert laws differ meaningfully from those in the Students for Fair Admission case. Ebony is law-enforcement legislation aimed at protecting children who are victims of crime. Courts have long recognized that “safeguarding the physical and psychological well-being of a minor” is a compelling interest.

Ebony Alert laws also address documented racial disparities in the Amber system that undermine equal protection and public safety. According to case law, race-conscious measures may be deemed compelling when “essential to accomplishing criminal system objectives within a community served,” including maintaining trust and perceptions of fairness. These points are developed more fully in our paper.

To be sure, Ebony Alerts are not a panacea. As the Minority and Missing Report emphasizes, there are broader issues, such as inconsistent reporting protocols, inadequate training and strained relations between marginalized communities and police.

Nonetheless, Ebony Alert proposals invite a broader reckoning with how race-neutral systems can produce racially unequal outcomes. Carefully designed race-conscious remedies may be necessary to fulfill the criminal legal system’s most basic promise: protecting children’s lives.

Read more of our stories about Philadelphia and Pennsylvania, or sign up for our Philadelphia newsletter on Substack.

The Conversation

Itay Ravid does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Nearly 1 in 3 missing children in the US are Black, driving Pennsylvania and other states to propose ‘Ebony Alerts’ to ensure equal protection and public safety – https://theconversation.com/nearly-1-in-3-missing-children-in-the-us-are-black-driving-pennsylvania-and-other-states-to-propose-ebony-alerts-to-ensure-equal-protection-and-public-safety-275388