On Passover, some Sephardic Jews revisit not only the story of their ancestors, but also their Ladino language

Source: The Conversation – USA (3) – By Bryan Kirschen, Associate Professor of Spanish and Linguistics, Binghamton University, State University of New York

Decorated ‘guevos haminados,’ or slow-cooked eggs, are a common Passover food for Sephardic Jewish families. sbossert/iStock via Getty Images Plus

When Passover arrives each spring, Jewish families around the world gather at their tables to retell a story passed down for thousands of years. At ritual dinners known as Seders, they recount the Exodus, the biblical story of the Israelites’ liberation from slavery in Egypt – asking questions, singing songs and explaining the meaning behind symbolic foods like matzo.

In the United States, most Seders move between English, Hebrew and Aramaic, which was once the lingua franca of much of the ancient Middle East. In some homes, another language joins the table: Ladino, a form of Judeo-Spanish that Jews carried across the Mediterranean after being expelled from Spain in 1492.

Multilingualism has long been part of Jewish tradition. For Sephardic Jews who spent centuries in Ottoman and Muslim lands after their forced exodus from Spain – or Sepharad, as it is called in Hebrew – Ladino has played a central role at Passover. For many families today, the holiday provides a rare opportunity to hear the now-endangered language spoken aloud – a focus of my sociolinguistic research.

My work with Sephardic communities has demonstrated the ways in which the language is preserved across generations. Just as the story of Passover is transmitted each year, the holiday also provides a recurring encounter with Ladino.

A message in Judeo-Spanish about Passover from Dallas resident Rachel Amado Bortnick, who is originally from Izmir, Turkey.

Spanish roots

To the ear, Ladino sounds very much like Spanish. However, it has been shaped by many other languages with which its speakers have come into contact: Hebrew, Arabic, Portuguese, French, Italian and Turkish, to name a few.

To the eye, however, Ladino used to look very different; it was traditionally written in Hebrew-based characters. Over the past century, most people who write the language have used the Latin alphabet.

A piece of paper filled with black script in Ladino in the Hebrew alphabet.
A handwritten Haggadah – or ‘Agada,’ in Ladino – from the late 1800s. The text, which is used during Passover Seders, includes Aramaic, Ladino and Hebrew.
Bryan Kirschen

Meanwhile, Ladino speakers assimilated to the majority languages of their countries – that is, if they were not from communities entirely wiped off the map during the Holocaust. Today, Ladino is an endangered language, spoken mostly by older Sephardic Jews.

However, since the turn of the 21st century, speakers from around the world have found new opportunities to communicate with each other, especially online.

Most speakers can be found in Israel, Turkey and the United States. A 2025 report from JIMENA, a Jewish nonprofit based in California, estimates that about 10% of Jews in the U.S. are Sephardic and/or Mizrahi. The latter term includes other populations of Jews from around the Middle East and North Africa. The Pew Research Center estimates that 4% of American Jews are Sephardic or Mizrahi, and another 6% say they are a combination of those groups and Ashkenazi – the term for Jews with ancestors from Eastern Europe.

Two varieties

“Ladino” is regularly used to refer to the everyday spoken language of Judeo-Spanish. Many native speakers simply call it “Spanyol” or “Espanyol.”

However, some speakers and scholars use the term “Ladino” to refer to a very particular variety: the form of the language found in religious materials like the Haggadah, the text that guides the Seder ritual. For many Sephardim, the word “Haggadah” also refers to the Seder itself.

This variety of Ladino preserves the structure of Hebrew, using a word-for-word translation – what linguists call a “calque.” For example, a native speaker might say “esta noche,” as in other varieties of Spanish, to refer to “tonight.” The Ladino textual tradition, though, reads “la noche la esta.” This mirrors the word order of the Hebrew phrase: “ha-laylah ha-zeh,” or “the night the this.”

That this practice has endured for centuries is both remarkable and, in some ways, unsurprising.

Sephardic populations once regularly spoke Judeo-Spanish as an everyday language, reserving the calque variety for religious or instructional contexts. Today, though, the spoken language is rarely transmitted to younger generations and has entered what linguists call a “post-vernacular” phase.

Many Sephardic Jews have completely lost the language of their ancestors, but others have preserved it and even found new ways to use it. One New York native with Sephardic roots in Turkey who I interviewed said she uses Ladino not just with relatives, friends and students, but even with “neighbors and Uber drivers, who are very interested in knowing more; when speaking to animals; or thinking by myself.”

Sephardic practices at Passover explained in an online ‘Enkontro de Alhad’ program, conducted in Judeo-Spanish.

Still, the calque variety – the word-for-word translation from Hebrew – persists. Importantly, someone does not need to be fluent in the spoken language to participate, just as many Jews can recite prayers, lists and songs in Hebrew and Aramaic without necessarily being able to communicate in those languages. In this sense, engaging with multiple languages is a natural part of Jewish cultural practice.

Honoring tradition

Just as Passover tells the story of the ancient Israelites’ exodus and liberation, the use of Ladino today is a story of survival.

In my research, American Sephardim share that it is important to preserve their families’ heritage, referring to themes such as tradition, ancestry, memory and nostalgia. One Los Angeles native with roots in Turkey and Greece noted that it’s important “to honor our family members who survived to pass things along to us … to create new memories for the next generation. I think my kids cherish that their Passover is different from others.” Another, a Seattle native with roots on the Greek island of Rhodes, said, “I want to keep it alive in some way or another. And the only way I’m able to do that is by using it at the Seder.”

A page from an illuminated manuscript with a flowered border and ornately colored Hebrew letters.
The ‘Sarajevo Haggadah,’ a 14th-century manuscript, originally came from a Sephardic Jewish community in Spain.
Zemaljski Muzej via Wikimedia Commons

Beyond the read-aloud portions of the Haggadah, Sephardim of different generations keep Judeo-Spanish alive through songs and cuisine. Traditional dishes include “mina de karne,” meat pie; “keftes de prasa,” leek patties; “guevos haminados,” slow-cooked eggs; “bimuelos,” fried fritters; and even “arroz,” rice – a staple in some communities, but less common in others.

The Seder provides many different ways to engage with the language, often alongside older generations who acquired varying degrees of proficiency from their forebears. One Los Angeles native whose family came from Rhodes shared that all five generations of her family and their guests sing Ladino songs like “Un Kavretiko” – which many other Jews know as “Chad Gadya,” or “One Little Goat” – and “Ken Supiense,” or “Who Knows One?” Each family makes deliberate decisions about language use, customizing traditions and even the Haggadah text to suit their cultural and linguistic needs.

Like the Passover story itself, Ladino persists through the voices of relatives who learned the language from generations before them. For many Sephardic families, the Passover Seder remains one of the few moments each year when these sounds return to the table, linking the past and present through shared practices of storytelling, memory and language.

The Conversation

Bryan Kirschen is affiliated with the American Ladino League.

ref. On Passover, some Sephardic Jews revisit not only the story of their ancestors, but also their Ladino language – https://theconversation.com/on-passover-some-sephardic-jews-revisit-not-only-the-story-of-their-ancestors-but-also-their-ladino-language-278290

US troops in Nigeria to help fight terrorism could end up making it worse – analyst

Source: The Conversation – Africa (2) – By Saheed Babajide Owonikoko, Researcher, Centre for Peace and Security Studies, Modibbo Adama University of Technology

The recent deployment of US soldiers in Nigeria to assist the west African country in its counterterrorism campaign could worsen Nigeria’s insecurity.

It might be perceived as a sign of weakness; deepen religious divisions; widen the rift between the Economic Community of West African State (Ecowas) and the breakaway Alliance of Sahel States (AES); provoke terrorist attacks; and hinder the development of Nigeria’s armed forces.

Since Nigeria’s 1999 transition to civil rule, insecurity has worsened in the country’s northern regions. In 2024, 9,662 people were killed nationwide, 86% of them in the north. In 2025, violent deaths rose to 11,968, with northern Nigeria still the most affected.

The first batch of US soldiers was deployed barely two months after the US bombed militants in Nigeria’s north-west on Christmas Day 2025.

The director of defence information at Nigeria’s defence headquarters said the US troops’ presence would give Nigerian troops access to specialised technical capabilities. This would strengthen Nigeria’s ability to deter terrorist threats and enhance the protection of vulnerable communities across the country.

This is not the first time foreign boots have been brought into Nigeria since its independence in 1960. Foreign soldiers were deployed to fight the Nigerian Civil War, and to re-professionalise the Nigerian Armed Forces.

Between December 2014 and April 2015, Nigeria is said to have hired a private military company called Specialised Tasks, Training, Equipment and Protection (STTEP) International, involving 100 to 250 South African ex-soldiers, for a direct combat role against insurgents in Maiduguri. The government denied this.

Now is the first time US soldiers will be deployed in a combat-related operation as part of Nigeria’s counterterrorism efforts. Among members of the public, there are divided opinions over this.

As a security scholar who researches Nigeria’s security crises, I have serious concerns that the deployment of US soldiers in Nigeria, regardless of their number, may exacerbate insecurity rather than improving it.

Why it may backfire

The armed forces of any country are an emblem of sovereignty. Foreigners in a combat operation against terrorism in another country may be framed domestically as a loss of control over security.

The US has long sought to station its Africa Command (Africom) in Nigeria. Nigeria resisted this, largely due to the sovereignty issue, regional politics in Ecowas and other strategic calculations. Since the US Christmas Day bombing, President Bola Tinubu has come under heavy criticism for not being able to truly act as commander-in-chief while a foreign power handles the security.

What is more, President Donald Trump has widened existing religious divisions across Nigeria by:

  • framing Nigeria’s security challenge as persecution of Christians

  • declaring Nigeria a country of particular concern

  • threatening to deploy the US military to Nigeria unilaterally to defend Christians.

Given this context, US boots on the ground in Nigeria may feed into several conspiracy narratives. One is the perception that the US is seeking access to Nigeria’s critical mineral resources.

It could reinforce the Alliance for Sahelian States-Ecowas crisis, deepening the security conundrum in the Sahel. Nigeria would likely be the most affected.

After the coups in Mali, Niger and Burkina Faso, and Ecowas efforts to force the coupists to return power to civilians, the Alliance of Sahel States formed and disengaged with western powers. Animosity developed between the two regional groupings.

The Alliance of Sahel States countries, which used to be allies of France and the US, have now shifted to Russia and China. Niger’s junta ordered the withdrawal of over 1,000 foreign military personnel and closure of US facilities, including a drone base in Agadez.

Russia currently has at least 1,500 foreign troops, tagged as the African Corps (previously Wagner), fighting in Mali alone.

The deployment of US troops to Nigeria, given the context of fracture within Ecowas and the shift in foreign alliances, could lead to an escalation of insecurity in the region.

Thirdly, the US is the global arrowhead of westernisation that most Islamist terrorist organisations usually select as the target of attacks. Boko Haram attacks in Nigeria and the support it gets from foreign terrorist organisations like al-Qaeda and ISIS are due largely to the perception that Nigeria is a proxy for the US.

With US soldiers in Nigeria, Nigeria’s value as a target for terrorist organisations may increase. There are already signs that terrorist attacks are escalating in Nigeria since the Christmas Day bombing.

Even with US troops deployed to Nigeria’s north-east, terrorist attacks have become more daring. On 5 March, Islamic State West Africa Province attacked military bases in Borno State. Several high-ranking military officers were killed and arms and ammunition were carted away.

If US forces are attacked, Trump is more likely to deploy more soldiers.

This was the case in Somalia in May 2017. Trump expanded US military operations in Somalia after a US Navy Seal was killed by al-Shabaab.

Even if the presence of the US soldiers in Nigeria is to help Nigerian Armed Forces in operational capacities such as intelligence, surveillance and reconnaissance, logistics and air power manoeuvres, heavy reliance on the US could weaken the long-term development of the Nigerian Armed Forces.

What to do

US support is key to Nigeria’s improved capability to address its security challenge, but this should not take the form of US military boots on the ground in Nigeria. It can come in the form of training support and supply of precision equipment. That would help to address critical shortages that affect Nigeria’s ability to deal with insecurity.

The Conversation

Saheed Babajide Owonikoko does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. US troops in Nigeria to help fight terrorism could end up making it worse – analyst – https://theconversation.com/us-troops-in-nigeria-to-help-fight-terrorism-could-end-up-making-it-worse-analyst-278112

Anthrax-causing bacteria have dwelled in soil for centuries – cycling through people, animals and earth

Source: The Conversation – USA – By Hannah Kinzer, Ph.D. Candidate in Public Health, Washington University in St. Louis

Without timely treatment, _Bacillus anthracis_ can cause fatal infection. CDC

The bacteria that cause deadly anthrax disease persist in the earth, a place their ancestors preferred over petri dishes and blood-filled tissues.

The bacteria that cause anthrax are called Bacillus anthracis. In the soil, they hang out and can form communities around plant roots. They also interact with neighboring organisms, though they’re an admittedly less-than-ideal neighbor to the soil-dwelling amoebae they infect and kill.

As a public health researcher, I am fascinated by how diseases move among people, animals and the environment. When I worked in a state health department, I was surprised to learn how the bacteria that cause anthrax cycle between land and the animals that rely on that land – including people.

Anthrax in the ecosystem

Give these bacteria alkaline-rich dirt, calcium and some nitrogen, and they happily subsist in the ground. If the temperature, humidity or acidity is not favorable, these bacteria can also slumber for decades in a spore form – underfoot and forgotten by nearly all except cattle.

Cattle, deer and other large herbivores disturb the abodes of bacteria. They sometimes unintentionally eat anthrax spores along with their food or are exposed to them through a cut. After anthrax spores enter the animal’s body, immune cells known as macrophages pick up these spores for removal. But instead of being destroyed like other intruding pathogens, the spores germinate and multiply.

Microscopy image of two or three long, thin orange rods being swallowed by two yellow blobs
Immune cells (yellow) engulfing anthrax bacteria (orange).
Volker Brinkmann/Wikimedia Commons, CC BY-SA

Once the spores take the form of bacteria, they can also mount an aggressive offensive. Anthrax bacteria can cleave vital proteins with toxins and wreak havoc on their cellular adversaries. Cattle succumb to the bacteria within days if left untreated – sometimes within 48 hours of infection.

Through the cattle’s death, the bacteria are brought back to the earth to vegetate or sporulate once more.

Humans seeding anthrax

People can get caught in the life cycle of Bacillus anthracis.

Throughout history, humans and animals have seeded new lands with Bacillus anthracis spores. The spores are hardy travelers: They can survive for over 50 years and are resilient to dehydration, radiation, toxic chemicals and enzymatic degradation.

Anthrax in early Egypt may have been one of the plagues described in the Bible. Animal husbandry texts in China have described anthrax for millennia. French explorers brought Bacillus anthracis spores to American soil in the early 1700s.

While people usually spread anthrax accidentally, there are infamous examples of anthrax spread on purpose.

In the 1930s and ’40s, Japanese military leaders released anthrax spores in Chinese villages, killing thousands of people. On Sept. 18, 2001, envelopes of spores were mailed to American media and congressional leaders, killing five people.

The weaponized use of Bacillus anthracis spores brings to mind white powder rather than the brown earth where they naturally lie.

Close-up of person handling envelope with gloved hand and pliers held in a plastic cover over a platform with the word 'ANTHRAX' in a red no symbol
Anthrax has been sent through the mail as an act of bioterrorism.
Pool Demange/MARCHI/Gamma-Rapho via Getty Images

Anthrax underfoot

Most cases of human anthrax result from working with animals – an occupational hazard for tanners, wool sorters and butchers.

Anthrax in people manifests as blisters and dark sores when a person is exposed to the spores through an open wound. When spores are inhaled, symptoms include fever, nausea and chest pain. Very few people ingest the bacteria or spores, but those who do typically get them from eating undercooked meat from an infected animal. Symptoms include vomiting, stomach pain and bloody diarrhea.

Inhalation anthrax is the most deadly type of anthrax. While researchers have estimated that 95% of people with inhalation anthrax die, this is based on historical outbreaks when patients often did not have timely diagnosis or treatment.

Treatment for anthrax includes antibiotics and monoclonal antibodies. William Smith Greenfield developed a vaccine to prevent anthrax around the same time that Louis Pasteur developed one in 1881. However, anthrax vaccines are currently recommended only for people at high risk of anthrax exposure, including animal handlers and U.S. military members.

Anthrax ecology

The bacteria that cause anthrax are forever associated with weapons that destroy people, overshadowing their ecologically complex role in animals and soils that sustain humanity.

In the soil, they interact with other organisms and plants in ways scientists are only beginning to understand. In animals, they are part of the circle of life and death that maintain populations.

Beneath the ever-expanding footprint of civilization, anthrax bacteria will continue to be inseparable from the earth that humans walk upon.

The Conversation

Hannah Kinzer does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Anthrax-causing bacteria have dwelled in soil for centuries – cycling through people, animals and earth – https://theconversation.com/anthrax-causing-bacteria-have-dwelled-in-soil-for-centuries-cycling-through-people-animals-and-earth-278288

Pittsburgh’s post-steel economy is a success – and a warning for other cities

Source: The Conversation – USA (2) – By Christopher Briem, Regional Economist, Center for Social and Urban Research, University of Pittsburgh

Slow and steady growth in higher education and health care led to economic advantages for Pittsburgh. YT412/iStock via Getty Images Plus

Few regions pose as much of an economic conundrum as Pittsburgh.

Is the city and region – once the center of American steelmaking – a paragon of postindustrial transformation, or a left-behind region still struggling to move beyond its industrial past?

I’m an economist at the University of Pittsburgh and author of the new book “Beyond Steel: Pittsburgh and the Economics of Transformation.” In it, I attempt to reconcile the economic paths that have shaped modern Pittsburgh as the city tries to redefine itself.

One core question is not why the steel industry in Pittsburgh collapsed, but why steel production remained so concentrated in the region for so long.

Past researchers foretold with uncanny accuracy the problems the region would face if it did not move away from its monolithic dependence on the steel industry. One prognostication, made by two University of Pittsburgh economists in the 1960s, stands out more than others.

Pittsburgh’s rebrand gets a global stage

When, in May 2009, White House Press Secretary Robert Gibbs announced that Pittsburgh would host the G20 Summit of world leaders that fall, the assembled journalists of the White House press corps presumed it was a lighthearted joke before Gibbs jumped into the substance of the day’s briefing.

A thin Black man in a suit and red tie speaks at a podium with world flags behind him.
President Barack Obama announced that Pittsburgh would the site of the 2009 G20 Summit, a choice meant to showcase the city’s postindustrial transformation.
Scott Olson via Getty Images News

Yet Gibbs was not joking. At the height of the Great Recession between 2007 and 2009, Pittsburgh was purposely chosen because of its history of overcoming past economic trauma and building new prosperity.

It would be a vision of Pittsburgh repeatedly highlighted by foreign media upon their arrival in Pittsburgh that fall for the summit. More than one major publication described Pittsburgh as “no longer hell with the lid off,” a play on a historical description of the city dating to the 1860s.

That idealized story is based on real change in a region that suffered extraordinary structural decline when a century of dependence on heavy industry imploded in the 1970s. Yet it is a story that needs to be tempered by the chronic poverty and lack of development in many former mill towns of southwestern Pennsylvania, which have not shared in the greater region’s redevelopment. Some communities, including Braddock – ironically, where Andrew Carnegie began his steelmaking empire in the 1870s – remain among the poorest in the nation.

How Pittsburgh reinvented itself

University of Pittsburgh economists Edgar M. Hoover and Ben Chinitz led a multiyear study of Pittsburgh’s regional economy funded by the Ford Foundation, a private foundation that works to advance human welfare, at the beginning of the 1960s. They described the economic study as an “immersion in regional economics.” Their four-volume distillation of all aspects of the Pittsburgh economy foretold the decline the region would face due to the shifting economic geography of the steel industry and Pittsburgh’s extreme lack of industrial diversification – things local leaders commonly saw as strengths.

Their comprehensive work left little doubt about Pittsburgh’s fate if the city stayed its course. But moving away from steel proved far too difficult for regional civic and business leaders, as the region was almost entirely dependent on steel production and related industries. By putting off real economic change, the collapse of the 1980s was even more painful when it finally arrived.

A man in a hard hat and reflective vest looks at an industrial fire.
After the steel industry collapsed in the 1980s, Pittsburgh reinvented its economy around health care, education and technology.
Michael Mathes/AFP Collection via Getty Images

Hoover and Chinitz’s message applied far beyond Pittsburgh. Pittsburgh may have been an extreme case, but they knew that all U.S. regions needed to learn to adapt in the face of accelerating and inexorable change. At the core of their thesis was the idea that many of the geographic linkages that had long bound certain industries to certain regions – like automotive in Michigan and meatpacking in the Midwest – were weakening. Just as the Pacific Northwest no longer relies on the timber industry, or as coal has failed to sustain prosperity in West Virginia, no region can rely on past dominance in any industry to ensure future prosperity.

Among other shifts they projected, Hoover and Chinitz foresaw that future competition between regions would not rest upon the ability to attract and retain specific industries. Instead, the success of regions would rest on their ability to attract and retain workers, something many regions long took for granted.

Workers and their families value regional amenities, affordability and many other factors that historically had little impact on corporate site selection. Today, the factors that make a region a place where workers want to live and work, like a strong job market, access to a quality education and affordable housing, shape the pattern of growth and decline among and within regions.

For Pittsburghers, whose city had for so long been singularly defined by the production of steel, the idea that industrial competitiveness was not paramount bordered on apostasy.

What other cities can learn from Pittsburgh

Pittsburgh’s transformation is incomplete, and ongoing. Looking ahead, history teaches us that all regions in the U.S. need to consider any current economic successes as temporary, eventually to be eviscerated by changing circumstances. Envisioning a future without steel was once an inconceivable scenario for Pittsburgh.

One of the key challenges Pittsburgh faced after the decline of steel was the significant loss of workers fleeing deindustrialization. At its economic rock bottom in the 1980s, Pittsburgh saw an exodus of young workers who saw their economic futures elsewhere. Those workers took with them their families and their future families, compounding and extending the repercussions of past job destruction. Rebuilding a competitive workforce took a career-span length of time, but is in many ways the core of Pittsburgh’s rebound.

Slow and steady growth in higher education and health care, and enviable success at research investment in tech, has built new competitive advantages. National firms including Google, Apple, Amazon and others have set up significant local operations to take advantage of the region’s current concentration of skilled workers.

The silhouette of a city in the background of a busy street.
One of the key challenges Pittsburgh faced after the decline of steel was the significant loss of workers.
UCG/Universal Images Group via Getty Images

Again, success is not spread evenly across the region. Where Pittsburgh’s new workers want to live, long-depressed communities, like Lawrenceville and East Liberty, have turned around, but where local amenities are lacking, depressed communities are finding it ever harder to abate decline. Many workers no longer need to live close to their jobs. Location of a major firm or factory is rarely enough to catalyze sustainable and prosperous communities.

It appears we are living in the future foretold by Ben Chinitz and Edgar M. Hoover. The message that workforce is crucial to economic development is now accepted in a way that was once difficult to accept. But workforce advantages, like most competitive advantages that regions have today, are fleeting.

The Conversation

Christopher Briem does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

ref. Pittsburgh’s post-steel economy is a success – and a warning for other cities – https://theconversation.com/pittsburghs-post-steel-economy-is-a-success-and-a-warning-for-other-cities-276814

Food aid doesn’t make people loafers – research shows government benefits help low-income people find jobs

Source: The Conversation – USA (2) – By Claudia Strauss, Professor of Anthropology, Pitzer College

Millie Morales believes in hard work.

“I feel that as an American citizen, we all have a great opportunity to be able to improve our life,” the 58-year-old woman explained in an interview I conducted with her in 2025. “Are you willing to put in the work, or are you not?”

Morales, whose name I changed to protect her privacy, was a stay-at-home mom devoted to caring for her large family. After her divorce, she worked at social service agencies and enrolled at a local college. Then her ex-husband stopped paying for child support, and she and her eight children faced eviction.

She said she is very grateful for the government benefits she received for the first time, including the Supplemental Nutrition Assistance Program, which helps low-income Americans buy groceries.

Those benefits made it possible for her to keep putting food on the table and remain housed until she earned a college degree and obtained jobs that could pay those bills. Now she assists families dealing with difficult medical decisions, a job that makes her feel she is able to help others through hard times in their lives.

Learning how people think about work

Morales is one of more than 100 Americans I have interviewed for my research on how people think about work and about government assistance. Currently, I am updating the research on how Americans think about government assistance, which is how I met Morales. Not all of the participants in these projects received SNAP benefits before or after these interviews.

But among those who had, I found her experience typical: SNAP provided a crucial source of support while they looked for work. With the exception of a few in their late 50s and 60s who faced age discrimination and eventually retired, all persisted until they found another job.

My research highlights that most of the people who get benefits through SNAP and other government programs want to work. And SNAP supports their work ethic.

Many Americans need jobs and benefits

A study co-authored by a group of people who got SNAP benefits and an academic research team found that most of the people with benefits would have preferred not to have to turn to the government for help. They get benefits only because their jobs tended to be precarious and pay too little to meet their basic needs.

The average SNAP benefits, which many people refer to as food stamps, as of 2025 are US$188 per person per month, which comes to about $6 a day. About 42 million low-income Americans receive them.

It’s worth noting that 58% of the people who get SNAP benefits are either under 18 or 60 and up. Many of the rest have disabilities of their own or are caring for young children or someone with disabilities – or fall into a combination of those three categories.

SNAP cuts are on the way

Morales was able to obtain the help she needed, but I also spoke with others who needed help and whose applications were denied. Now the holes in the safety net are growing.

Some provisions in the large tax and budget bill that Congress passed in July 2025 could jeopardize the SNAP benefits for millions of Americans.

For example, it expanded the number of people who will be subjected to a three-month limit on SNAP benefits.

And for the first time, the federal government will no longer cover the full cost of benefits; this will start with the 2028 fiscal year, which begins on Oct. 1, 2027. The big 2025 tax and budget package will also halve the federal government’s share of states’ administrative costs, starting Oct. 1, 2026.

Many states may have no choice but to reduce or eliminate benefits, threatening support for millions of Americans.

Agriculture Secretary Brooke Rollins, whose department oversees SNAP, has said the new rules will “reflect the importance of work and responsibility.”

In other words, the new rules presume that SNAP benefits undermine recipients’ work ethic. There are exceptions, of course, but my research and that of others shows that presumption is wrong for most people who receive those benefits.

How SNAP affects a willingness to work

The government first imposed work requirements for most working-age adults to receive food stamps in the 1970s. It has set time limits for most “able-bodied adults without dependents” since 1996, making some exceptions during severe recessions.

Among families that include children and working-age adults without disabilities who receive SNAP benefits, more than 9 in 10 include someone with a job.

These requirements can become counterproductive when people who get SNAP benefits have to miss work, for example, to provide proof of their employment track record because their caseworkers have lost their paperwork.

A real-world SNAP experiment

Economists Jason B. Cook and Chloe N. East noted in a study originally published in 2023 and revised in 2025 that the caseworker an applicant is assigned can affect whether someone’s SNAP application gets approved.

Caseworkers don’t make the approval decisions, but they vary in their diligence in ensuring that applicants answer all the required questions. Applicants who are unlucky in the caseworker they are assigned are less likely to provide all the relevant information, leading to a denial.

Comparing applicants who were randomly assigned to more helpful or less helpful caseworkers, the economists followed what happened to nearly 200,000 SNAP applicants in one state, tracking their employment and earnings for three years whether or not they received SNAP benefits.

If Secretary Rollins is right that SNAP benefits undermine a work ethic, someone who doesn’t receive benefits should be working more than someone who is the same in other ways but does receive benefits. But that’s not what Cook and East found.

The economists found that for people who had previously held steady jobs, those who received SNAP benefits were far more likely to be working again two and three years later than the ones who were denied benefits.

And they were earning more money as well.

They also found that for SNAP applicants who had not worked steadily before applying for benefits, receiving benefits made no difference to their future employment.

In other words, SNAP benefits and similar programs that help people facing economic hardship can make someone more likely to earn income rather than less so. They do this by providing some of the money low-income people need to put food on the table so they can focus on finding a good job.

As Millie Morales put it, “If I don’t have a decent place to eat and sleep and shower and take care of myself, how am I then supposed to go look for a job, or go to a job, or go to school?”

The Conversation

Claudia Strauss has received funding from NSF and the Wenner-Gren Foundation. No current funding.

ref. Food aid doesn’t make people loafers – research shows government benefits help low-income people find jobs – https://theconversation.com/food-aid-doesnt-make-people-loafers-research-shows-government-benefits-help-low-income-people-find-jobs-275659

Teens are driving the demand for online abortion pills via telehealth – new research

Source: The Conversation – USA (3) – By Dana Johnson, Postdoctoral Fellow in Health Disparities Research, University of Wisconsin-Madison

Abortion pills have been shown to be safe and effective. MementoJpeg/Moment via Getty Images

Teens in the U.S. are obtaining medication abortion pills through telehealth, and young people age 18 to 24 are ordering medication abortion at much higher rates than older adults.

Those are the key findings of a new study that my colleagues and I published in the journal JAMA Health Forum.

We examined requests for medication made to an online telemedicine service – one of the few to support people in all 50 states, without age restrictions. We compared average weekly request rates both before and after the Supreme Court overturned Roe vs. Wade in June 2022. Over time, we examined request rates across three age groups (15-17, 18-24 and 25-49) and by the severity of state-level abortion restrictions.

After Roe was overturned, researchers expected the number of abortions across the U.S. to fall. Intuitively, this makes sense, as most states have at least one law substantially restricting abortion services, which limits access at a clinic.

However, research from the Society of Family Planning #WeCount project shows the opposite: that the number of abortions has increased nationwide. The trend was even seen in states that ban abortion.

The main reason for this is the steep rise in medication abortion services through telehealth, which has expanded access for tens of thousands of people. As of early 2025, an estimated 1 in 4 abortions are done via telehealth. Until now, research and media attention have largely focused on this phenomenon among adults rather than among teenagers.

Why it matters

Understanding this trend among adolescents is important because minors – or teenagers under 18 – face a unique legal situation when it comes to abortion.

More than 7 million teenage girls age 13 to 17 live in a state with an abortion ban, and the legal landscape is quickly changing for teens.

In most states, adolescents seeking abortion services must navigate parental involvement laws, which require a minor to obtain consent for, or notify a parent of, their abortion. Such laws make it difficult or even impossible for many teens under 18 to obtain care, even in states like Massachusetts or Pennsylvania that have moved to protect abortion access.

In some cases, teens seek judicial bypass services, which help them circumvent the parental involvement process. In addition to legal barriers, teens who seek abortion may already face stigma around teen pregnancy and sex, likely lack reliable access to a car – or may not even have a driver’s license – and probably don’t have US$600 or more on hand to pay for an abortion at a clinic.

To circumvent these barriers, minors are bypassing parental involvement requirements and requesting telehealth at higher rates in states with parental involvement laws, compared with their counterparts in more liberal abortion access states.

This is important because this trend may be evidence of the huge barrier of parental involvement laws. It may also signal that states with parental involvement laws also have additional policies restricting abortion – such as mandatory waiting periods or gestational bans – and that minors are living in an even more restrictive policy context than adults.

What still isn’t known

More research is needed to understand how and why teens are turning to online providers. Findings will help clinicians and advocates support adolescents who are ordering telehealth medication abortion online.

There are some very real legal risks involved for any teenager ordering pills online, and young people have been criminalized for taking abortion pills ordered from online sources.

Furthermore, anti-abortion prosecutors and lawmakers frequently target teens. For example, Idaho has become notorious for passing an “abortion trafficking” law, which makes it illegal to help minors access abortion.

At the federal level, attempted revisions to the Food and Drug Administration’s approval of the abortion drug mifepristone have explicitly tried to ban access for minors, and federal officials continue to spread misinformation about the safety of medication abortion for teens.

The Research Brief is a short take on interesting academic work.

The Conversation

Dana Johnson receives funding from the National Institute of Health, the Society of Family Planning Research Fund, and the UW-Madison Collaborative for Reproductive Equity. She also serves on the Board of Directors for Jane’s Due Process.

Laura D. Lindberg is affiliated with Youth Reproductive Equity and Power to Decide

ref. Teens are driving the demand for online abortion pills via telehealth – new research – https://theconversation.com/teens-are-driving-the-demand-for-online-abortion-pills-via-telehealth-new-research-277943

A connection to nature fuels well-being worldwide, according to a study of 38,000 people

Source: The Conversation – USA (3) – By Stylianos Syropoulos, Assistant Professor of Psychology, Arizona State University

Across cultures, languages and economic systems, feeling connected to the natural world is consistently linked to living a more hopeful, purposeful and resilient life. nymphoenix/iStock via Getty Images Plus

When life feels overwhelming, many people instinctively turn to nature. A walk in a park. Sitting by the ocean. Watching a sunset. Is this just a pleasant feeling, or is there something deeper at work?

A multitude of studies have linked spending time in nature with different aspects of mental health and wellness. For example, immersing oneself in outdoor natural spaces seems to lift depression and influence brain activity patterns. The effect may be especially relevant in children. But most research on this question has looked at people living in so-called WEIRD societies – Western, educated, industrialized, rich and democratic.

As environmental psychologists based in the U.S. and in Germany, we were part of a team of more than 100 researchers who set out to examine this phenomenon on a global scale and determine how consistent it is around the world.

Across countries as diverse as Brazil, Japan, Nigeria, Germany and Indonesia, we saw a clear pattern: People who felt more connected to nature also reported higher well-being.

Worldwide oneness with nature

Researchers who study people’s relationship with the natural world often use the term “nature connectedness.” This phrase doesn’t simply mean going hiking or visiting a park. Nature connectedness refers to the extent to which people see nature as part of who they are – whether they feel an emotional bond with the natural world and experience a sense of oneness with it.

Someone who has a high degree of nature connectedness might agree with statements like, “My relationship to nature is an important part of who I am.” It reflects identity and meaning, not just exposure.

In a new study, people who had a stronger sense of nature connectedness tended to have a higher degree of mindfulness.

We drew on data collected between 2020 and 2022 from more than 38,000 participants through a large international collaboration that was established to gauge how people responded to the COVID-19 pandemic. Participants came from 75 countries and were on average in their teens, 20s or 30s. They completed questionnaires that explored the link between people’s bond with nature and several aspects of well-being.

The questionnaires probed people’s sense of purpose in life; their feelings of hope, life satisfaction and optimism; their sense of resilience and their ability to cope with stress they felt; as well as whether they practice mindfulness as they go through their everyday life.

Across this large international sample, we found that people who felt more connected to nature consistently reported higher levels of well-being and mindfulness. This was true not just for feeling satisfied with life but also for deeper aspects of flourishing, such as having a sense of direction and meaning. And these associations held even when accounting for age and gender.

Does national context matter?

We also explored whether specific characteristics of a country strengthen the benefits of feeling connected with nature.

For example, we looked at things such as how well countries take care of their air, and water systems and ecosystems, as well as whether citizens have equal access to education, democratic participation, and other key social and financial resources, and whether cultures tend to prioritize collective well-being over individual priorities. There were some differences, but the main takeaway was pretty clear: A connection with nature and well-being shows up across a wide range of economic, cultural and environmental contexts.

In other words, the psychological benefits of feeling connected to nature do not appear to be limited to wealthy Western nations or specific cultural worldviews.

A child plays with sand in in front of a rock formation in Monument Valley
Bonding with nature may make people more resilient.
Mike Tauber/Tetra Images via Getty Images

Why might connection matter?

One reason why feeling a connection with nature may be linked to well-being is that nature connectedness fosters mindfulness – the ability to be present and attentive.

In our data, people who had a stronger sense of nature connectedness tended to have a higher degree of mindfulness, which is itself strongly linked to mental health.

Another possibility is that bonding with nature may also make people more resilient. People who feel connected to something larger than themselves may find it easier to cope with stress and uncertainty. A sense of belonging – even to the natural world – can provide psychological grounding in a world characterized by stressors. There may also be a feedback loop: Feeling better may encourage people to engage more deeply with nature, strengthening the bond over time.

Implications for policy and everyday life

These findings matter beyond academic debates. Around the world, policymakers are increasingly recognizing the links between human health and environmental sustainability. International agreements such as the Convention on Biological Diversity, a landmark treaty signed by 196 countries in 1992, emphasize the importance of restoring humanity’s relationship with nature.

These policy actions seek to protect Earth’s ecosystems, but our results suggest they may also benefit people’s psychological well-being. Similarly, designing cities with accessible green spaces, incorporating nature-based experiences into schools and supporting community engagement with local environments may do more than beautify neighborhoods – they may also help people flourish.

Across cultures, languages and economic systems, feeling connected to the natural world is consistently linked to living a more hopeful, purposeful and resilient life. At a time when mental health challenges are rising globally, reconnecting with nature is not a luxury but a fundamental – and widely shared – human need.

The Conversation

The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

ref. A connection to nature fuels well-being worldwide, according to a study of 38,000 people – https://theconversation.com/a-connection-to-nature-fuels-well-being-worldwide-according-to-a-study-of-38-000-people-276572

New federal student loan limits affect social work graduate students, with impacts for survivors of domestic violence in Colorado and elsewhere

Source: The Conversation – USA (2) – By Kaitlyn M. Sims, Assistant Professor of Public Policy, University of Denver; Institute for Humane Studies

The status change cuts the amount of federal student aid by half. Royalty-free/Getty Images

As of July 2026, graduate degree programs in nursing, public health, social work, public policy and more will no longer be defined as professional degrees by the Department of Education.

The change limits how much federal financial aid students in those programs can qualify for under new borrowing limits set by the big tax and spending cuts bill passed by Congress in 2025.

The Department of Education said excluding these degrees from the professional degree classification is solely an “internal definition” and “not a value judgment about the importance of (these) programs.” The department argues these changes will push some graduate programs to reduce their tuition costs.

Every day, survivors of domestic violence rely on a care network built and maintained by a system of nurses, forensic nurse examiners, social workers, therapists and emergency shelter managers. Many of these jobs require graduate training that comes with substantial education costs. To afford these degrees, students often rely on federal financial aid.

The status change will cut the amount of lifetime federal aid students in these programs can receive by about half relative to students in professional programs. In combination with ongoing federal funding cuts, the change threatens to destabilize an already strained social service system.

We are faculty and student researchers at the University of Denver’s Systems, Housing, and Anti-violence Policy Evaluation Lab. We are alarmed at what the status change means for social service providers, especially those serving survivors of domestic and sexual violence.

Excluding programs that prepare individuals to work with survivors of domestic violence from the professional degree designation risks discouraging entry into these professions nationwide. Fewer people entering the profession will impact both the quality and availability of care for those who rely on these services. Moreover, increasing the amount of private debt students will take on to complete these degrees will have lasting consequences.

Professional degree classification and loans

Under the new rules going into effect this summer, graduate student borrowers face annual loan limits and lifetime caps on total borrowing for federal student aid.

Graduate students in professional degree programs, which include medicine, law, dentistry and other high-cost degrees, can access federal loans of up to US$50,000 per year and $200,000 in total.

Taking away the professional degree label from programs limits students to $20,500 in annual federal loans and a lifetime cap of $100,000 for graduate study. But program costs remain unchanged.

In Colorado, and elsewhere, the cost of graduate education often exceeds what students can pay without borrowing. The new cap of $20,500 per year for students in nonprofessional graduate degree programs is far less than the total cost of attendance at major Colorado universities.

At the University of Colorado Boulder, annual costs can top $38,000 including food, housing, books and transportation for in-state students with a full-time credit load. Tuition and fees alone cost about $16,000.

A stone sign reads
Entering Colorado State University in Fort Collins comes at a cost.
Don and Melinda Crawford/UCG/Universal Images Group via Getty Images

At Colorado State University, costs range from $36,000 for in-state students to $57,000 for out-of-state students. At the University of Denver, some programs can approach $80,000 per year after housing and other personal expenses are accounted for.

For students who cannot pursue these degrees without adequate financial aid, this policy will create barriers to entering the field. Others will be saddled with private debt that lacks the protections and favorable borrowing terms of federal loans.

Undergraduates can access income-based aid through the Free Application for Federal Student Aid, known as FAFSA. That includes Pell Grants, which are need-based financial aid for undergraduate students, and subsidized loans.

Graduate students lack comparable need-based grant programs and instead rely largely on direct, unsubsidized loans and Grad PLUS loans, which cover educational expenses not met by other financial aid, such as food, housing and books. But the Grad PLUS loan program is set to end for new borrowers on July 1, 2026, further tightening access to advanced degrees.

A calculator and a pen sit on a stack of papers that read
People seeking undergraduate degrees can apply for income-based financial aid through the Free Application for Federal Student Aid program, known as FAFSA.
Royalty-free/Getty Images

Impacts on long-term labor force

Removing these programs from the list of professional status degrees that qualify for higher loans delivers both a symbolic and financial blow to the essential services that support survivors of domestic violence.

Denise Smith, assistant professor at the University of Colorado Anschutz College of Nursing, told Denver7 the policy leaves nurses feeling devalued. She argues that this reinterpretation of the professional degree definition could reduce growth in the nursing profession, with long-term impacts on patients’ access to care.

The New York Academy of Medicine cautions that restricting financial aid will shut out students from lower-income backgrounds, reverse progress in workforce diversity and erode respect for vital health professions at a time when trust in evidence-based care is already stretched thin.

Victim advocacy roles such as shelter managers and housing navigators, which sometimes require a graduate degree, are already chronically underpaid. The median annual salary for social workers nationwide is about $61,000.

Analysts argue that limiting how much students can borrow to earn the credentials they need may accelerate the collapse of the workforce pipeline. Some of these professions, such as nursing, already face a critical shortage of workers.

In fields that rely on moral wages – compensating poorly paid staff with the intrinsic satisfaction of helping those in need – recognition matters. The work done by graduates with these degrees has not changed, and the skills these workers bring to domestic and sexual violence response programs are still vital.

Why this matters

In Colorado, where many shelters operate at or above capacity and most counties don’t have their own shelter program, we believe the impact of fewer trained service professionals would be especially acute.

According to a 2025 survey by NO MORE, an advocacy coalition supporting victims of domestic violence, 80% of organizations in the sexual and domestic violence sector in the U.S. have experienced service disruptions due to federal funding instability. A multistate survey in 2021 of domestic violence programs found that 90% reported high staff turnover due to inadequate funding and the lack of livable wages. State coalitions against domestic violence say employees who remain at these jobs often juggle multiple roles and face substantial burnout.

Shrinking the pipeline of trained professionals who work with victims of domestic violence will disproportionately harm low-income, rural and marginalized survivors, not just in Colorado but nationwide. Fewer professionals means fewer safe options and longer waits for critical services.

Trauma-informed counseling in shelters and community programs is critical for survivors’ recovery and long-term well-being. However, long waits to access shelter or see a mental health professional, along with workforce shortages, already limit access. Fewer forensic nurses to conduct sexual assault exams further threatens survivor safety, especially amid nationwide nursing shortages.

In rural and underserved areas, advanced practice nurses – those with advanced clinical practice and education experience – are often the only consistent providers of care for the local population. Reducing support for nurse training puts entire communities at risk and weakens vital services, including documentation of abuse that can be essential for domestic violence legal proceedings.

These combined challenges highlight the fragility of the system that supports survivors. Without continued investment in training and recognition for these professionals, the network that provides safety and support will be weakened even further.

The Conversation

Kaitlyn M. Sims receives funding from the Wisconsin Department of Children and Families, the Denver Basic Income Project, the Arnold Ventures Foundation, and the Institute for Humane Studies.

Kaelyn Lara and Leslie Carvalho do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

ref. New federal student loan limits affect social work graduate students, with impacts for survivors of domestic violence in Colorado and elsewhere – https://theconversation.com/new-federal-student-loan-limits-affect-social-work-graduate-students-with-impacts-for-survivors-of-domestic-violence-in-colorado-and-elsewhere-276254

Jürgen Habermas dies at 96: a philosopher whose hopes for a better future are more important than ever

Source: The Conversation – UK – By Susan Smith, Honorary Professor of Geography, University of Cambridge

Jürgen Habermas speaking in 2007. 360b/Shutterstock

It is impossible to capture seven decades of formidable intellect, wrapped into some 14,000 books and articles, in less than a thousand words. Yet German philosopher Jürgen Habermas staked his career on the power of dialogue and deliberation, so it is worth chiming in.

Habermas, who died on March 14 at the age of 96, was among the greatest thinkers of our time. He was unshakeable in his conviction that people have minds of their own, can hope for a better future, and have the capability, collectively and democratically, to bring that future to life.

Born in Düsseldorf in 1929, he escaped conscription to the Wehrmacht by a whisker. His later realisation that, as a child, he had been enveloped by “a politically criminal system” propelled him into a lifelong scholarly, political and personal campaign to rescue democracy and restore the future.

It was an uphill struggle of breathtaking proportions. If the best was still to come, the journey towards enlightenment would require “nothing less than a comprehensive theory of modern society and its underlying dynamics”.

That was the scholarly project, and few 20th century theorists could tackle it. Habermas led the way with sweeping interdisciplinary reach: historical understanding, geographical imagination, sociological insight, grasp of legal theory, sustained engagement with ethics, aesthetics, psychology, epistemology, theology and more. Any one of these approaches would have moved the dial, but in Habermas they came together with a powerful political message.

Variously described as a socialist, democrat, internationalist, and above all humanitarian, his philosophy – practical, perhaps pragmatic – was his politics. Its centrepiece was the formation, functioning and fragility of a public sphere – Öffentlichkeit – mediating between states and civil societies, promising an alternative to the authoritarian, totalitarian regimes he eschewed.

Bookended by two landmark works, Habermas’s lifelong conviction was that the formation of public opinion through rational, reasoned conversation was vital for the conduct and survival of parliamentary democracy. Both works are cautionary tales concerned equally with the forces stifling deliberative democracy and with the conditions in which it might flourish.

The first, the Structural Transformation of the Public Sphere (1962) finds the scope for informed, inclusive, critical debate compromised by the intrusion of calculative, commercial and bureaucratic interests. Six decades later, A New Structural Transformation of the Public Sphere and Deliberative Politics (2022) takes on the algorithms driving social media. These, he argued – by accident, design or vested interests – fragment the public sphere, undermining the possibility for collective action against environmental change, excessive inequality and more.

Meanwhile, anchored on the two-volume Theory of Communicative Action (1981), Habermas mounted a sustained effort to make the public sphere work.

What scholar in the humanities and social sciences in the last half century is untouched by this project? My own reckoning, for example, was his prequel on Knowledge and Human Interests (1968). Once you realise that knowledge is not a thing to be discovered but a practice constituted by competing interests, there is no going back.

We were all critical theorists then, on a self-reflective pilgrimage to more rational, fairer futures. Habermas stayed with us every step of the way, not least because he did not confine himself to scholarly books and articles. His journalistic output and other public interventions were equally prodigious. Consider, for example, some 12 volumes of talks, speeches and commentary gathered in his Kleine Politische Schriften.

There is, it must be said, a well-developed feminist critique – and re-visioning – of Habermas’ core ideas. Those very public spaces in which deliberative democracy thrives (if it does) have traditionally been occupied by men, and are generally exclusionary in other ways. Not that such challenges fazed Habermas, who regularly exchanged views with a wide range of public intellectuals. These debates were how he expected the future to unfold.

Hope for the future

For Habermas, hope has not always triumphed over experience. Early in his career he underestimated how tame “conversation” might seem to his students. In the middle years, he probably oversold the potential of intellectuals to steer public debate.

More recently, a trend towards democratic decline and strengthening authoritarianism might suggest that he fell into a classic “democracy trap”. Was it futile to hope that the mandate for fully enfranchised populations to choose their governments through regular free and fair elections would spread?

Habermas was, in fact, acutely aware that the capacity for deliberative democracy can never be taken for granted. However, he never gave up on its promise. On this, he wrote actively to the end, sometimes controversially.

Not everyone liked his style: one obituary describes him as “brilliant, influential and stupefyingly tedious”. But the more telling view is that his work “has given us a vocabulary in which the promises of dignity, autonomy, and emancipation are kept alive and true”.

All in all, Habermas’ achievements are a valorisation of everything that populism is not. He held fast to his conviction that deep knowledge and cogent arguments can win the day, that even the smallest gesture towards a better world is worth the effort.

That is why a recent reviewer could describe his final three-volume project – Also a History of Philosophy – as “a work of willed optimism”. And it is why, in his last work, a collection of biographical conversations – Things Needed to Get Better – Habermas still pins his hopes on critical dialogue and reasoned debate.

This article features references to books that have been included for editorial reasons, and may contain links to bookshop.org. If you click on one of the links and go on to buy something from bookshop.org The Conversation UK may earn a commission.

The Conversation

Susan Smith has received funding from the ESRC, ARC and AHURI. She is affiliated with the British Academy and the University of Cambridge.

ref. Jürgen Habermas dies at 96: a philosopher whose hopes for a better future are more important than ever – https://theconversation.com/jurgen-habermas-dies-at-96-a-philosopher-whose-hopes-for-a-better-future-are-more-important-than-ever-279020

Could a new type of weight-loss pill shake up the market? Here’s what to know about orforglipron

Source: The Conversation – UK – By Martin Whyte, Associate Professor of Metabolic Medicine, University of Surrey

Orforglipron, a small-molecule drug, has just passed phase 3 trials. antoniodiaz/ Shutterstock

A new type of daily pill has proven more effective for weight loss and blood sugar control than its currently available counterparts, according to a recent trial. The drug, known as orforglipron, could be a game-changer in the rapidly expanding oral weight-loss drug market.

The advent of the injectable weight-loss drug semaglutide (known better by its brand names Wegovy and Ozempic) marked a distinct shift in the weight-loss drugs market when it became available just a few years ago.

Semaglutide is a class of glucagon-like peptide-1 (GLP-1) medication. These drugs mimic the gut hormone GLP-1, which is released soon after eating. This hormone signals fullness to the brain, slowing digestion and stimulating the release of insulin. By replicating the action of this hormone, GLP-1 drugs have proven highly effective at managing type 2 diabetes and promoting weight loss.

Although semaglutide is widely used, a key issue with the drug is that it needs to be injected into the belly, thighs or back of the arm. This can make it difficult for patients with needle phobia or who don’t want to self-inject due to the inconvenience.

Another logistical issue with injectable GLP-1 drugs is that they require refrigeration throughout the supply chain. This can pose a challenge in low- and middle-income countries.

It’s for these reasons that researchers and developers have started investigating the efficacy of oral versions of semaglutide.

Based on current research, it appears that oral semaglutide is very effective. However, it must be taken on an empty stomach – and users must wait 30 minutes before eating or drinking.

Alongside being expensive to produce, it also has poor bioavailability compared with injectable semaglutide. This means only about 1% of the ingested drug is absorbed and able to exert its effects.

But a recent phase 3 clinical trial has shown that a new type of oral weight-loss pill may have overcome these issues – proving to be more effective than the current oral semaglutide products on the market.

Oral weight-loss pill

The recent 52-week phase 3 trial involved 1,698 adults with type 2 diabetes across six countries. It set out to compare current oral semaglutide products against orforglipron, which is also taken as a daily tablet.

The primary measure researchers were looking for was a reduction in HbA1c. This blood test reflecting average blood sugar levels over three months is the standard indicator of diabetes control. Diabetes is present if HbA1c is 6.5% or more.

From a baseline average HbA1c of 8.3%, it was found that after 52 weeks, orforglipron was able to reduce this value by an average of 1.71–1.91%. In comparison, oral semaglutide only reduced HbA1c by 1.47%.

Not only did orforglipron meet the trial’s goals of proving it was as effective to oral semaglutide, it proved it was superior for lowering blood sugar. The participants who took orforglipron also lost more weight – an average of 6.1kg-8.2kg, compared with 5.3kg in those taking semaglutide.

However, a key issue highlighted by the trial was one of tolerability.

GLP-1 drugs can cause gastrointestinal side-effects such as nausea, vomiting, diarrhoea and constipation. In this latest trial, around 59% of participants on orforglipron reported such symptoms, compared with 37–45% on semaglutide.

The reason for this difference may be the more prominent, daily peak drug concentrations with orforglipron. The consequence was that around 10% of orforglipron participants discontinued treatment due to adverse effects. Just 4-5% of those taking semaglutide discontinued treatment.

Two vials of injectable GLP-1 drugs (such as Wegovy) sitting next to three blister packs of pills.
Future studies may want to look at how orforglipron compares with injectable semaglutide.
Caroline Ruda/ Shutterstock

No head-to-head trials have been done of injectable GLP-1 versus orforglipron. However, the weight loss seen in this study of people with type 2 diabetes is broadly comparable with that previously observed with injectable GLP-1.

Market implications

The trial’s results show that orforglipron, which was developed by Eli Lilly, can be considered one of semaglutide’s most credible challengers.

Another remarkable thing about orforglipron is that it belongs to a new category of drugs called small-molecule drugs. This means it’s a synthetic chemical compound small enough to be absorbed directly through the gut wall. There, it’s able to act on GLP-1 receptors, even though it isn’t of a similar structure to a GLP-1 hormone.

Oral semaglutide, on the other hand, is a peptide drug. This means the structure of its amino acids (one of the building blocks of protein) closely resembles that of the natural GLP-1 hormone.

As a small-molecule drug, orforglipron is cheaper and simpler to manufacture than peptide-based drugs such as semaglutide.

And as with oral semaglutide, it requires no refrigeration. This gives it a logistical advantage over injectable GLP-1 formulations – a potentially important consideration for expanding access in low- and middle-income countries, where cold chain infrastructure is unreliable.

It remains to be seen, however, how orforglipron will perform against oral semaglutide in the broader market.

Although this latest trial has shown it is superior for controlling blood sugar and aiding weight loss, its higher rate of side-effects and treatment discontinuation may temper enthusiasm. In a crowded and competitive market, long-term adherence – shaped as much by tolerability as by efficacy – is probably a critical differentiator.

Orforglipron is still undergoing trials in patients with obesity but without diabetes.

The Conversation

Martin Whyte has received research funding from Novonordisk and Eli Lilly.

ref. Could a new type of weight-loss pill shake up the market? Here’s what to know about orforglipron – https://theconversation.com/could-a-new-type-of-weight-loss-pill-shake-up-the-market-heres-what-to-know-about-orforglipron-277302