Kiwi in Darwin recovering from a ‘very stormy night’ after Cyclone Fina

Source: Radio New Zealand

Roofing partially collapsed on the first floor of Royal Darwin Hospital as a result of the wild weather.

Roofing partially collapsed on the first floor of Royal Darwin Hospital as a result of the wild weather. Photo: Supplied / ABC News

A New Zealander living in the Australian city of Darwin has survived a “very, very stormy night”, as Tropical Cyclone Fina tore through the Northern Territory capital.

Laurent Marsch, who moved from Auckland in March, has been hunkering down in his apartment.

He told RNZ of significant damage, especially to the Royal Darwin Hospital in the northern suburb of Tiwi.

“This is the first cyclone we’ve had in six years,” he said. “This one started at category two and then intensified to a category three overnight.

“It’s intensifying to a category four, but it’s going over the sea, so just a lot of rain at the moment.”

Marsch said several trees had also been uprooted, but he was not quite sure of the extent of the damage to his new home.

“They’re still busy assessing that… they’ll only know in the next few days, I guess.”

The ABC reports Fina was the strongest cyclone to pass through Darwin since the deadly Cyclone Tracy in 1974.

The system was also more powerful than Cyclone Marcus, which struck Darwin as a category two in 2018.

However, Fina has not changed Marsch’s mind about his move across the ditch – which came with a $40,000 pay rise in his role as a correctional officer, on top of Australia’s minimum 12 percent superannuation contribution.

“There’s nothing I miss about Auckland.

“The only thing I miss is my kids and my grandkids – that’s the only thing I miss.”

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– Published by EveningReport.nz and AsiaPacificReport.nz, see: MIL OSI in partnership with Radio New Zealand

Why Oscar-winning artist quit Hollywood – and what made him return

Source: Radio New Zealand

Academy Award–winning artist Kazu Hiro says the cruelty of a few actors eventually chipped away at his love for the craft he had devoted his life to — pushing him to walk away from Hollywood.

The Japanese-American special and makeup effects artist is behind some of Hollywood’s most astonishing metamorphoses: Jim Carrey in How the Grinch Stole Christmas (2000), Angelina Jolie in Salt (2010), Gary Oldman in Darkest Hour (2017) and, more recently, Dwayne Johnson in The Smashing Machine (2025).

Working under Oscar-winning makeup titan Rick Baker early in his career, Hiro had little control over his assignments.

Makeup and Hairstyling for Bombshell, Kazu Hiro attends the 92nd Annual Academy Awards at Hollywood and Highland on February 09, 2020 in Hollywood, California.

Special effects and make-up artist Kazu Hiro.

Amy Sussman / Getty Images / AFP

– Published by EveningReport.nz and AsiaPacificReport.nz, see: MIL OSI in partnership with Radio New Zealand

High-rise living in Nairobi’s Pipeline estate is stressful – how men and women cope

Source: The Conversation – Africa – By Mario Schmidt, Associate Researcher, Max Planck Institute for Social Anthropology

Within sight of Kenya’s main international airport in Nairobi’s east, Pipeline residential estate stands out like a sore thumb. Composed almost entirely of tightly packed high-rise tenement flats, the estate has been described by the media as an urban planning nightmare. They point to its garbage problem, its waterlogged and frequently impassable streets, and the effect of dense living conditions on children’s health.

Pipeline’s transformation started roughly two decades ago. High-rise apartment blocks were a response to demand for low-cost rental housing in the rapidly urbanising capital. Individual private developers gradually converted the area, roughly 2km², into a dense, high-rise residential district. On average each block of flats hosts 200 or 300 tenants.

Pipeline is an example of how private sector developers can contribute to solving Nairobi’s housing crisis. But it’s also an example of how unregulated and poorly planned housing construction can have a negative impact on the social, economic and psychological well-being of households.

Pipeline is not the only tenement district in Nairobi. But it is one of the densest neighbourhoods in the city of over 4 million. The quality of buildings varies, but there are similarities:

  • rental flats mainly comprise single rooms with shared ablutions

  • unit design gives little attention to lighting, air circulation, or open space

  • tenants are forced into unfavourable rental relationships, where delays or default in payments can lead to water or electricity cuts.

The flats in Pipeline are almost exclusively inhabited by rural-urban migrants. They are attracted here by cheap accommodation and the promise of modernity. The flats have running water, tiled floors, individual electric meters and formal rental agreements.

We are researchers who study urban development, urban migration, and urban communities. Our fieldwork research sought to understand how the physical and social spaces created in neighbourhoods like Pipeline shape the experience of stress and pressure among men and women. We also looked at the strategies they apply to cope or reduce social, economic and romantic pressure.

Pipeline is a marked improvement from the options provided in Nairobi’s traditional informal settlements. Still, most basic services in the area are intermittent, or privatised. This is because the unplanned densification has outpaced the capacity of public infrastructure and services. This forces residents to pay for education, health, water, recreation and other services.




Read more:
Nairobi’s slum residents pay a high price for low quality services


Many of these tenants are unemployed, or employed in low-wage industrial work, precarious gig work, or domestic work.

We found that men and women experience and try to cope with stress in diverse ways. Both men and women located the cause of their distress within their marital home. But the meanings and reactions to that stress diverged sharply in the migrant household.

We found that migrant men tend to experience stress in the form of pressure and migrant women in the form of tiredness.

Previous evidence points to the different ways in which stress is experienced based on biological differences between men and women. However, we propose that the tight coupling between men and pressure and between women and tiredness is the result of the expectation that men will be breadwinners. This drives men towards action and prevents women from expressing a will towards action.

Fieldwork and findings

We discovered our shared interest in studying Nairobi’s high-rise estates during a workshop on urban Nairobi.

Mario had carried out longitudinal ethnographic work with rural–urban migrants in Pipeline. His two-year-long fieldwork mostly took place in near-exclusively male spaces, such as gyms, barber shops and bars. Roughly 50 in-depth qualitative interviews revealed how men navigated urban lives that were increasingly defined by stress, pressure and exhaustion.

Miriam’s research focused on how Nairobi’s privately developed low-cost tenement precincts created environments of everyday urban dysfunction.

After the first meeting, we concluded that it would be beneficial to get a deeper understanding of women’s experiences of stress. This would help us to understand men’s and women’s experiences of stress and pressure. It would also enable us to compare how these different groups managed and coped with stress.

We designed a semi-structured questionnaire and conducted interviews with a dozen female residents. The interviewees spanned single and married women, members of a financial self-help group (chama), female neighbours who usually spent time together on balconies, a sex worker, and an entrepreneur who owned a hair salon.

Comparing the two sets of interviews provides ethnographic support for our hypothesis, which is that men and women tend to experience different types of stress: masculine “pressure” and feminine “tiredness”.

Masculine pressure is defined as an experience that provokes action. The pressure is intrinsically attached to the cause of stress and driven by the hope that overcoming it will promise social validation linked to the male provider model.

The male interviewees tended to engage in outward-oriented strategies to overcome this pressure. These include social drinking, extramarital affairs, or violent reaffirmations of gender identity. In this way, the form and design of Pipeline offered plentiful avenues for commercialised, stress-reducing activities.




Read more:
How elites and corruption have played havoc with Nairobi’s housing


In contrast, feminine tiredness emerged as an experience that inhibited action. Female respondents were constrained from aggressive responses, lest they risk being branded immoral or losing vital male financial support.

Married women, or single parents, found themselves largely confined to the small apartments. Their inward-oriented coping strategies were sometimes identified as “doing nothing” or watching TV, or performing household tasks. This passive endurance of stress was also seen as a means to “persevere” (Kiswahili: kuvumulia). In some cases, women used intermediate semi-private spaces, such as balconies, chamas or church, to connect with neighbours.

Taken together, these responses and expectations structure the modes by which male and female migrants react to or attempt to mitigate or relieve stress. This stress is not only caused by poverty but by expectations of middle-class success, ideals of romantic family life and economic progression.

Conclusions

As yet, there are no policies or programmes that seek to reverse the complex challenges created through neighbourhoods like Pipeline. Kenya’s national affordable housing programme is focused on home-ownership solutions. However, with over 90% of the city’s population renting their dwellings, and 87% renting from private individuals, Nairobi needs a better solution for rental housing.




Read more:
Kenya’s push for affordable housing is creating opportunities despite barriers


This could be through redevelopment and area-based upgrading, expansion of basic social and community services, incentives for private developers to incrementally upgrade their housing stock, rental and tenant protection legislation, and support for sustainable, communal, and cooperative housing alternatives spearheaded by citizens themselves.

The Conversation

Mario Schmidt received funding from the German Research Foundation and the Max Planck Institute for Social Anthropology. He currently works for Busara, Nairobi (Kenya).

Miriam Maina undertook this research as part of her Postdoctoral research work at the African Cities Research Consortium (ACRC) in the University of Manchester. The ACRC is a a six-year investment by FCDO to fund new, operationally-relevant research to address intractable development challenges in African cities.

– ref. High-rise living in Nairobi’s Pipeline estate is stressful – how men and women cope – https://theconversation.com/high-rise-living-in-nairobis-pipeline-estate-is-stressful-how-men-and-women-cope-265499

Africa’s hidden stillbirth crisis: new report exposes major policy and data gaps

Source: The Conversation – Africa (2) – By Mary Kinney, Senior Lecturer with the Global Surgery Division, University of Cape Town

Nearly one million babies are stillborn in Africa every year. Behind every stillbirth is a mother, a family and a story left untold. Most of these are preventable, many unrecorded, and too often invisible. Each number hides a moment of heartbreak, and every uncounted loss represents a missed opportunity to learn and to act.

As a public health researcher specialising in maternal and newborn health, I have spent the past two decades working on strengthening health systems and quality of care across Africa. My research has focused on understanding how health systems can prevent stillbirths and provide respectful, people-centred care for women and newborns. Most recently, I was part of the team that led a new report called Improving Stillbirth Data Recording, Collection and Reporting in Africa. It is the first continent-wide assessment of how African countries record and use stillbirth data.

The study, conducted jointly by the Africa Centres for Disease Control and Prevention, the University of Cape Town, the London School of Hygiene & Tropical Medicine and the United Nations Children’s Fund, surveyed all 55 African Union member states between 2022 and 2024, with 33 countries responding.

The burden of stillbirths in Africa is staggering. Africa accounts for half of all stillbirths globally, with nearly eight times higher rates than in Europe. Even stillbirths that happen in health facilities may never make it into official statistics despite every maternity registry documenting this birth outcome.

Part of the challenge is that there are multiple data systems for capturing births and deaths, including stillbirths, like routine health information systems, civil registration and other surveillance systems. But these systems often don’t speak to each other either within countries or between countries. This data gap hides both the true burden and the preventable causes.

Despite advances in several countries to prevent stillbirths, large gaps remain, especially on data systems. Only a handful of African countries routinely report stillbirth data to the UN, and many rely on outdated or incomplete records. Without reliable, comparable data, countries cannot fully understand where and why stillbirths occur or which interventions save lives.

Strengthening stillbirth data is not just about numbers; it is about visibility, accountability and change. When countries count every stillbirth and use the data for health system improvement, they can strengthen care at birth for mothers and newborns and give every child a fair start in life.

Findings

The report was based on a regional survey of ministries of health. This was followed by document reviews and expert consultations to assess national systems, policies and practices for stillbirth reporting and review.

The report reveals that 60% of African countries have national and sub-national committees responsible for collecting and using stillbirth data, which produce national reports to respective health ministries. But data use remains limited. Capacity gaps, fragmented systems and insufficient funding prevents many countries from translating information into action.

To guide investment and accountability, the report categorises countries into three readiness levels:

  1. Mature systems needing strengthening, such as Kenya, Rwanda and Uganda. These countries have consistent data flows but need more analysis and use.

  2. Partial systems requiring support, where reporting mechanisms exist but are not systematically implemented, like Ghana, Malawi and Tanzania.

  3. Foundational systems still being built, including fragile or conflict-affected countries like South Sudan and Somalia. Here, policies and structures for data collection and use remain absent.

The findings show both progress and persistent gaps. Two-thirds of African countries now include stillbirths in their national health strategies, and more than half have set reduction targets. Nearly all countries report that they routinely record stillbirths through their health sectors using standard forms and definitions, yet these definitions vary widely. Most systems depend on data reported from health facilities. But the lack of integration between health, civil registration and other data systems means that countless losses never enter national statistics.

For example, if a woman delivers at home alone in Mozambique and the baby is stillborn, the loss is only known to the family and community. Without a facility register entry or civil registration notification, the death never reaches district or national statistics. Even when a stillbirth occurs in a health centre, the health worker may log it in a facility register but not report it to the civil registration system. This means the loss of the baby remains invisible in official data.

What this means

Stillbirths are a sensitive measure of how health systems are performing. They reflect whether women can access timely, quality care during pregnancy and at birth. But unlike maternal deaths, which are often a benchmark for health system strength, stillbirths remain largely absent from accountability frameworks.

Their causes, like untreated infections, complications during labour, or delays in accessing emergency caesarean sections, are often preventable. The same interventions that prevent a stillbirth also reduce maternal deaths. These improve newborn survival, and lay the foundation for better health and development outcomes in early childhood.

Accurate data on stillbirths can guide clinical care and direct scarce resources to where they are needed most. When data systems are strong, leaders can identify where and why stillbirths occur, track progress and make informed decisions to prevent future tragedies.

The analysis also highlights promising signs of momentum. Over two-thirds of countries now reference stillbirths in national health plans, an important marker of growing political attention. Several countries are moving from isolated data collection to more coordinated, system-wide approaches. This progress shows that change is possible when stillbirths are integrated into national health information systems and supported by investment in workforce capacity, supervision and data quality.

What’s needed

Africa has the knowledge, evidence and experience to make change happen.

The report calls for harmonised definitions, national targets and stronger connections and data use between the different data sources within and across African countries. Above all, it calls for collective leadership and investment to turn information into impact, so that every stillbirth is counted, every death review leads to learning and no parent grieves alone.

The author acknowledges and appreciates the partners involved in developing the report and the support from the Global Surgery Division at UCT.

The Conversation

Mary Kinney and the team at UCT receive funding from UNICEF, Laerdal Foundation, and the South African Medical Research Council.

– ref. Africa’s hidden stillbirth crisis: new report exposes major policy and data gaps – https://theconversation.com/africas-hidden-stillbirth-crisis-new-report-exposes-major-policy-and-data-gaps-268901

The secret mission to save Gaza’s historical artefacts

Source: Radio New Zealand

Brushing away layers of soot and dust, archaeologist Hanin Al-Amassi examines the brittle pages of a manuscript carrying the weight of Gaza’s history.

The item once sat in the Omari Mosque, one of Gaza’s oldest and most revered landmarks in the heart of Gaza City’s old quarter.

Covering 4100 square metres and with a courtyard of 1190 square metres, the site was once a cornerstone of Gaza’s religious and cultural life until it was flattened during more than 15 months of Israeli attacks on the strip.

Video poster frame

This video is hosted on Youtube.

– Published by EveningReport.nz and AsiaPacificReport.nz, see: MIL OSI in partnership with Radio New Zealand

Paul Costelloe, personal designer to Princess Diana, dies at 80

Source: Radio New Zealand

Irish fashion designer Paul Costelloe, personal designer to the late Princess Diana, who became a fixture at London Fashion Week for four decades, has died aged 80, his family said in a statement, quoted by local media.

Costelloe was appointed as Diana’s personal designer in 1983, shortly after establishing his own label, Paul Costelloe Collections, and their collaboration continued until her death in a car crash in Paris in 1997.

He led the development of all his collections from his studio in central London, was invited to show at the city’s premier catwalk event in its inaugural year in 1984 and was there in September to present his latest spring-summer creations.

Costelloe died peacefully, surrounded by his wife and seven children in London following a short illness, the family said in the statement quoted by local media. A spokesperson for Costelloe could not immediately be reached for comment.

He was born in Dublin in 1945, where he initially trained before moving to Paris’ revered Chambre Syndicale de la Haute Couture and then to another fashion capital, Milan, where he was a designer for the luxury department store La Rinascente.

Costelloe spent some time in New York, where he established his own label before settling in London, where his partnership with Princess Diana flourished. His collections today include womenswear, menswear, bags, homeware and jewellery.

“Paul led a remarkable life as a leading figure in Irish, UK and international fashion and business for decades. He built a hugely successful business through incredible talent, discipline, and an unwavering commitment to quality,” Ireland’s deputy prime minister Simon Harris said in a statement.

“His was and is a quite remarkable Irish success story.”

– Published by EveningReport.nz and AsiaPacificReport.nz, see: MIL OSI in partnership with Radio New Zealand

Bullied contestant gets payback by capturing Miss Universe crown

Source: Radio New Zealand

Fátima Bosch Fernández of Mexico has been crowned Miss Universe 2025, a dramatic victory for a 25-year-old at the centre of the turbulent 74th staging of the popular beauty pageant in Bangkok who stood up to public bullying from one of the hosts.

The issues at this year’s event sprang from a sharp-tongued scolding of Bosch, which sparked a controversy marked by a walkout, feminist solidarity and a teary, melodramatic apology from the local organiser who set it all off.

When Bosch was announced as the winner, cheers and screams erupted from the audience, with Mexican flags waved by elated supporters.

Miss Mexico Fatima Bosch (C) is surrounded by contestants as she celebrates winning the 2025 Miss Universe pageant in Nonthaburi, north of Bangkok, on November 21, 2025.

Miss Mexico Fatima Bosch (C) is surrounded by contestants as she celebrates winning the 2025 Miss Universe pageant in Nonthaburi, north of Bangkok, on 21 November, 2025.

AFP / Lillian Suwanrumpha

– Published by EveningReport.nz and AsiaPacificReport.nz, see: MIL OSI in partnership with Radio New Zealand

Effets secondaires des chimiothérapies : une molécule française prometteuse pour lutter contre les neuropathies périphériques, dont souffrent près de 90 % des patients

Source: The Conversation – in French – By Laurence Lafanechère, Directrice de recherche CNRS, Université Grenoble Alpes (UGA)

Une nouvelle molécule capable de protéger les neurones des effets toxiques de la chimiothérapie, tout en renforçant l’efficacité de certains traitements anticancéreux, a été découverte et offre des résultats prometteurs chez l’animal. Une start-up a été créée pour continuer son développement et mener des études chez l’humain.


Picotements dans les mains et les pieds, brûlures, douleurs, perte de sensibilité, sensation d’engourdissement… Les neuropathies périphériques figurent parmi les effets secondaires les plus fréquents de la chimiothérapie, touchant jusqu’à 90 % des patients pour certains traitements. Leur sévérité conduit parfois les praticiens à ajuster, voire à réduire les doses de chimiothérapie, ce qui peut en diminuer l’efficacité.

Dans un cas sur quatre, ces atteintes nerveuses persistent des mois, voire des années après la fin du traitement. Elles rappellent alors chaque jour aux patients qu’ils ont eu un cancer – alors même que leurs cheveux ont repoussé et que les nausées ou la fatigue ont disparu. Aucun droit à l’oubli, même une fois la maladie vaincue

À ce jour, hormis le port de gants et de chaussons réfrigérants pendant les séances de chimiothérapie – une méthode pas toujours efficace et souvent désagréable –, aucun traitement préventif n’existe. Quelques médicaments palliatifs sont utilisés, pour atténuer la douleur, avec une efficacité modeste.

Notre équipe, en collaboration avec des chercheurs états-uniens et français, vient de franchir une étape importante avec la découverte d’un composé, baptisé Carba1, capable de protéger les neurones des effets toxiques de la chimiothérapie, tout en renforçant l’efficacité de certains traitements anticancéreux. Ces travaux viennent d’être publiés dans la revue Sciences Advances.

Une molécule, deux cibles

Carba1 appartient à la famille des carbazoles, une classe de molécules développée par les chercheurs du Centre d’études et de recherche sur le médicament de Normandie (CERMN), avec lesquels nous collaborons depuis plus de dix ans.

Nos travaux ont mis en évidence que Carba1 agit sur deux cibles principales.

Premièrement, Carba1 interagit avec la tubuline, la brique de base des microtubules. Selon les besoins de la cellule, ces briques peuvent s’assembler pour former soit des « câbles » capables de tirer et de séparer les chromosomes lors de la division cellulaire, soit des « rails » sur lesquels se déplacent des moteurs moléculaires transportant nutriments et organites comme les mitochondries, assurant ainsi la distribution de l’énergie et des ressources dans toute la cellule.

Ce système de transport est particulièrement essentiel dans les cellules nerveuses, dont les prolongements peuvent atteindre plus d’un mètre de longueur, par exemple les neurones qui partent du ganglion rachidien, près de la moelle épinière et vont innerver la peau des pieds. De nombreux médicaments anticancéreux, tels que le paclitaxel (Taxol) ou le docétaxel (Taxotère), ciblent déjà ces structures afin de bloquer la prolifération des cellules tumorales. Cependant, cette action n’est pas sans conséquence : les neurones, eux aussi dépendants des microtubules pour le transport de leurs constituants, en sont affectés, ce qui constitue l’une des causes majeures des neuropathies.

Nous avons montré que Carba1 modifie subtilement les microtubules : il perturbe leur extrémité, favorisant la liaison du paclitaxel. Cette interaction permet d’utiliser des doses plus faibles du médicament anticancéreux sans perte d’efficacité contre les tumeurs.

Mais ce n’est pas tout.

Des neurones plus résistants

Deuxièmement, en examinant plus en détail les propriétés de Carba1, nous avons découvert qu’il agit également sur un autre front : le métabolisme énergétique. Les neurones figurent parmi les cellules les plus gourmandes en énergie, et la défaillance bioénergétique est considérée comme l’un des principaux facteurs contribuant à la dégénérescence neuronale.

Nos résultats montrent que Carba1 active directement une enzyme clé, la nicotinamide phosphoribosyltransférase (NAMPT), qui relance la production de NAD⁺, molécule cruciale pour la génération d’énergie. Résultat : les neurones deviennent plus résistants au stress métabolique et survivent mieux aux agressions des agents chimiothérapeutiques.

Nous avons confirmé l’effet neuroprotecteur de Carba1 sur des cultures de neurones exposées à trois agents chimiothérapeutiques connus pour induire une neuropathie, via des mécanismes différents : le paclitaxel (ciblant les microtubules), le cisplatine (agent alkylant) et le bortézomib (inhibiteur du protéasome).

Contrairement aux cultures témoins où s’étendent des prolongements neuritiques lisses et vigoureux, dans les cultures traitées par ces médicaments, les prolongements présentent un aspect fragmenté, caractéristique d’un processus de dégénérescence. En revanche, lorsque les neurones sont exposés à ces mêmes traitements en présence de Carba1, leurs prolongements demeurent intacts, indiscernables de ceux des cultures non traitées. Ces observations indiquent que Carba1 protège efficacement les neurones de la dégénérescence induite par ces agents neurotoxiques.

Des résultats encourageants chez l’animal

Pour aller plus loin, nous avons testé Carba1 dans un modèle de neuropathie chez le rat traité au paclitaxel, développé par le Dr David Balayssac à Clermont-Ferrand (unité Neurodol). Ce traitement provoque une hypersensibilité cutanée : les rats réagissent à des pressions très faibles sur leurs pattes, un signe de douleur neuropathique. L’analyse histologique montre également une diminution des terminaisons nerveuses intra-épidermiques, tandis que le sang présente des taux élevés de NfL (chaîne légère de neurofilaments), marqueur de dégénérescence neuronale.

Lorsque Carba1 est administré avant et pendant le traitement, ces altérations disparaissent : les nerfs restent intacts, la concentration de NfL demeure normale et la sensibilité cutanée des animaux reste inchangée. Autrement dit, Carba1 protège les neurones de la dégénérescence induite par le paclitaxel. Signe rassurant, Carba1 n’impacte pas la croissance tumorale.

Comme les neurones, les cellules cancéreuses consomment beaucoup d’énergie. Il était donc essentiel de vérifier que Carba1 n’avait pas d’effet pro-tumoral et qu’il ne diminuait pas l’efficacité du paclitaxel. Pour le savoir, nous avons administré Carba1 seul, ou en association avec une dose thérapeutique de paclitaxel, à des souris porteuses de tumeurs greffées. Les résultats sont clairs : Carba1 n’a provoqué aucun effet toxique, ni altéré la santé générale des animaux, ni stimulé la croissance des tumeurs. Il n’interfère pas non plus avec l’action anticancéreuse du paclitaxel.

Une nouvelle voie vers des traitements mieux tolérés

Cette découverte est particulièrement enthousiasmante, car elle combine deux effets rarement réunis :

  • renforcer l’efficacité des médicaments anticancéreux de la famille du paclitaxel (taxanes) en permettant d’en réduire la dose ;

  • préserver les nerfs et améliorer la qualité de vie des patients pendant et après le traitement.

Avant d’envisager un essai clinique chez l’humain, plusieurs étapes restent indispensables. Il faut d’abord confirmer la sécurité de Carba1 chez l’animal, déterminer la dose minimale efficace et la dose maximale tolérée. Enfin, il sera nécessaire de mettre au point une formulation adaptée à une administration chez l’humain.

Cette mission incombe désormais à la start-up Saxol, issue de cette recherche, dont je suis l’une des cofondatrices. Si ces étapes – qui devraient s’étendre sur cinq ans au moins, selon les défis techniques et les levées de fonds – se déroulent comme prévu, Carba1 pourrait devenir le premier traitement préventif contre la neuropathie induite par la chimiothérapie – une avancée majeure qui pourrait transformer la façon dont les patients vivent leur traitement anticancéreux.

Carba1 incarne une innovation à l’interface de la chimie, de la neurobiologie et de l’oncologie. En associant protection neuronale et renforcement de l’efficacité thérapeutique, cette petite molécule pourrait, à terme, réconcilier traitement du cancer et qualité de vie. Pour les millions de patients confrontés à la double épreuve du cancer et de la douleur neuropathique, elle représente un espoir concret et prometteur.

The Conversation

Laurence Lafanechère est cofondatrice et conseillère scientifique de la Société SAXOL.
Pour mener ses recherches elle a reçu des financements de :
Société d’Accélération de Transfert de Technologies Linksium Maturation grant CM210005, (L.L)
Prématuration CNRS (LL)
Ligue contre le Cancer Allier et Isère (LL, C.T, D.B.)
Ruban Rose (LL)

– ref. Effets secondaires des chimiothérapies : une molécule française prometteuse pour lutter contre les neuropathies périphériques, dont souffrent près de 90 % des patients – https://theconversation.com/effets-secondaires-des-chimiotherapies-une-molecule-francaise-prometteuse-pour-lutter-contre-les-neuropathies-peripheriques-dont-souffrent-pres-de-90-des-patients-269727

Why celebrity scandals leave us feeling shattered

Source: Radio New Zealand

Celebrity scandals are a staple diet of mainstream media, and sometimes that means seeing your favourite artist, actor or influencer in a new light.

Whether it’s controversy around a jeans ad, voting for a political party you disagree with, or criminal allegations, it can feel confronting to learn more about a person you admire.

“When you find out information that is contradictory about what you believe, or how you [personally] would behave, it’s really quite shocking and disappointing,” explains Danya McStein, a psychologist and media consultant. “It shatters that image you had of the person.”

A digital advertising display featuring US actress Sydney Sweeney is seen outside an American Eagle store in Times Square in New York City.

American actress Sydney Sweeney’s controversial campaign for the clothing brand American Eagle sparked a debate about beauty standards and race.

TIMOTHY A. CLARY / AFP

– Published by EveningReport.nz and AsiaPacificReport.nz, see: MIL OSI in partnership with Radio New Zealand

The world lost the climate gamble. Now it faces a dangerous new reality

Source: The Conversation – UK – By James Dyke, Assistant Director of the Global Systems Institute, University of Exeter

FrankHH / shutterstock

Ten years ago the world’s leaders placed a historic bet. The 2015 Paris agreement aimed to put humanity on a path to avert dangerous climate change. A decade on, with the latest climate conference ending in Belém, Brazil, without decisive action, we can definitively say humanity has lost this bet.

Warming is going to exceed 1.5°C. We are heading into “overshoot” within the next few years. The world is going to become more turbulent and more dangerous. So, what comes after failure?

Our attempt to answer that question gathered the Earth League – an international network of scientists we work with – for a meeting in Hamburg earlier this year. After months of intensive deliberation, its findings were published this week, with the conclusion that humanity is “living beyond limits”.

Exceed 1.5°C and not only do extreme climate events, like droughts, floods, fires and heatwaves grow in number and severity, impacting billions of people, we also approach tipping points for large Earth regulating systems like the Amazon rainforest and the Greenland and West Antarctic ice sheets. Tropical coral reef systems, livelihood for over 200 million people, are unlikely to cope with overshoot.

This translates to existential risks for billions of people. Not far in the future, but within the next few years for extreme events, and within decades for tipping points.

How global warming and social instability increase together:

The missed opportunities between 1997 and 2015 are the failures of the Kyoto protocol to bend the global emissions curve. There then followed a missed decade since the Paris agreement.

The beauty of Paris – getting all countries to commit collectively to cut emissions – has been undermined by the voluntary mechanisms to achieve it. So while staying well below 2°C is legally binding, the actions within national plans are not.

We are now at a critical juncture. We are at or very close to human caused environmental change that will fundamentally unpick the life-sustaining systems on Earth. These risk triggering feedback loops, for example, the accelerating die back of rainforests which would release billions of tons of carbon dioxide which would raise temperatures even further.

Ultimately that could cause the planet to drift away along the pathway to “hothouse Earth”, a scenario where even if emissions were reduced, self amplifying feedback loops would drive global temperature increases up to or even beyond 5°C. The last time the climate warmed by such an amount was tens of millions of year ago.

Well before this nightmare scenario, significant impacts are now unavoidable. Increasingly destructive storms will produce more loss and damages, more loss of life. Efforts to accelerate – or even maintain – decarbonisation could be undermined by social and political destabilisation created by climate change.

If the consequences of climate change begin to interfere with our efforts to deal with its causes, moves towards a more sustainable world risk being delayed or even entirely derailed.

But the scale of suffering is still very much up to us. We still have the ability to minimise overshoot. The best science can offer today, is a future where peak warming reaches 1.7°C before returning to within 1.5°C in 75 years.

This requires immediate action at global scale, on multiple fronts:

First, we’ll have to accelerate the fossil fuel phase out to achieve at least 5% annual global emission reductions from now on. This requires increasing nations’ decarbonisation plans by at least a factor of ten.

Second, we must transform the global food system within the next decade so it is able to absorb 3 billion tons of carbon dioxide a year.

Third, we need new ways to remove an additional 5 billion tonnes of carbon dioxide from the atmosphere each year, and store it safely in the ground. Whether by restoring ecosystems such as forests and wetlands or with new approaches that would directly remove carbon dioxide from the atmosphere, this must be done in safe and socially just ways.

Finally, we must do all we can to ensure continued “health” and resilience in nature on land and in the ocean, in order to safeguard Earth’s capacity to store carbon. All this needs to happen, simultaneously, to have a chance of limiting overshoot and come back to at or below 1.5°C of global warming.

Science is crystal clear here. Our only chance to recover back to a stable and safe climate is to accelerate the phase-out of fossil-fuels, remove carbon and invest in nature (on land and in the ocean), and do that without trading off between them.

The Conversation

The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

– ref. The world lost the climate gamble. Now it faces a dangerous new reality – https://theconversation.com/the-world-lost-the-climate-gamble-now-it-faces-a-dangerous-new-reality-270392